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Metacaspases

(2011) CELL DEATH AND DIFFERENTIATION. 18(8). p.1279-1288
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Biotechnology for a sustainable economy (Bio-Economy)
Abstract
Metacaspases are cysteine-dependent proteases found in protozoa, fungi and plants and are distantly related to metazoan caspases. Although metacaspases share structural properties with those of caspases, they lack Asp specificity and cleave their targets after Arg or Lys residues. Studies performed over the past 10 years have demonstrated that metacaspases are multifunctional proteases essential for normal physiology of non-metazoan organisms. This article provides a comprehensive overview of the metacaspase function and molecular regulation during programmed cell death, stress and cell proliferation, as well as an analysis of the first metacaspase-mediated proteolytic pathway. To prevent further misapplication of caspase-specific molecular probes for measuring and inhibiting metacaspase activity, we provide a list of probes suitable for metacaspases.
Keywords
TRYPANOSOMA-BRUCEI, REGULATES APOPTOSIS, ARABIDOPSIS-THALIANA, LEISHMANIA-MAJOR METACASPASE, CASPASE-LIKE ACTIVITY, YEAST SACCHAROMYCES-CEREVISIAE, protein aggregation, in vivo degradome, cell proliferation, caspase, metacaspase, PROGRAMMED CELL-DEATH, substrate specificity, PLANT EMBRYOGENESIS, CYSTEINE PROTEASES, FISSION YEAST

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Citation

Please use this url to cite or link to this publication:

Chicago
Tsiatsiani, Liana, Frank Van Breusegem, P Gallois, A Zavialov, E Lam, and PV Bozhkov. 2011. “Metacaspases.” Cell Death and Differentiation 18 (8): 1279–1288.
APA
Tsiatsiani, L., Van Breusegem, F., Gallois, P., Zavialov, A., Lam, E., & Bozhkov, P. (2011). Metacaspases. CELL DEATH AND DIFFERENTIATION, 18(8), 1279–1288.
Vancouver
1.
Tsiatsiani L, Van Breusegem F, Gallois P, Zavialov A, Lam E, Bozhkov P. Metacaspases. CELL DEATH AND DIFFERENTIATION. 2011;18(8):1279–88.
MLA
Tsiatsiani, Liana, Frank Van Breusegem, P Gallois, et al. “Metacaspases.” CELL DEATH AND DIFFERENTIATION 18.8 (2011): 1279–1288. Print.
@article{1865252,
  abstract     = {Metacaspases are cysteine-dependent proteases found in protozoa, fungi and plants and are distantly related to metazoan caspases. Although metacaspases share structural properties with those of caspases, they lack Asp specificity and cleave their targets after Arg or Lys residues. Studies performed over the past 10 years have demonstrated that metacaspases are multifunctional proteases essential for normal physiology of non-metazoan organisms. This article provides a comprehensive overview of the metacaspase function and molecular regulation during programmed cell death, stress and cell proliferation, as well as an analysis of the first metacaspase-mediated proteolytic pathway. To prevent further misapplication of caspase-specific molecular probes for measuring and inhibiting metacaspase activity, we provide a list of probes suitable for metacaspases.},
  author       = {Tsiatsiani, Liana and Van Breusegem, Frank and Gallois, P and Zavialov, A and Lam, E and Bozhkov, PV},
  issn         = {1350-9047},
  journal      = {CELL DEATH AND DIFFERENTIATION},
  language     = {eng},
  number       = {8},
  pages        = {1279--1288},
  title        = {Metacaspases},
  url          = {http://dx.doi.org/10.1038/cdd.2011.66},
  volume       = {18},
  year         = {2011},
}

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