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Bacterial and plant signal integration via D3-type cyclins enhances symptom development in the Arabidopsis-Rhodococcus fascians interaction

Elisabeth Stes UGent, Stefania Biondi, Marcella Holsters UGent and Danny Vereecke UGent (2011) PLANT PHYSIOLOGY. 156(2). p.712-725
abstract
The phytopathogenic actinomycete Rhodococcus fascians drives its host to form a nutrient-rich niche by secreting a mixture of cytokinins that triggers plant cell division and shoot formation. The discrepancy between the relatively low amount of secreted cytokinins and the severe impact of R. fascians infection on plant development has puzzled researchers for a long time. Polyamine and transcript profiling of wild-type and cytokinin receptor mutant plants revealed that the bacterial cytokinins directly stimulated the biosynthesis of plant putrescine by activating arginine decarboxylase expression. Pharmacological experiments showed that the increased levels of putrescine contributed to the severity of the symptoms. Thus, putrescine functions as a secondary signal that impinges on the cytokinin-activated pathway, amplifying the hormone-induced changes that lead to the formation of a leafy gall. Exogenous putrescine and treatment with polyamine biosynthesis inhibitors combined with transcript and polyamine analyses of wild-type and mutant plants indicated that the direct target of both the bacterial cytokinins and plant putrescine was the expression of D3-type cyclins. Hence, the activated D-type cyclin/retinoblastoma/E2F transcription factor pathway integrates both external and internal hormonal signals, stimulating mitotic cell divisions and inducing pathological plant organogenesis.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
BIOSYNTHESIS, GROWTH, THALIANA, CYTOKININ, CELL-CYCLE, POLYAMINE METABOLISM, SPERMIDINE SYNTHASE, INSERTIONAL MUTAGENESIS, GENE-EXPRESSION, SEED DEVELOPMENT
journal title
PLANT PHYSIOLOGY
Plant Physiol.
volume
156
issue
2
pages
712 - 725
Web of Science type
Article
Web of Science id
000291146800023
JCR category
PLANT SCIENCES
JCR impact factor
6.535 (2011)
JCR rank
7/189 (2011)
JCR quartile
1 (2011)
ISSN
0032-0889
DOI
10.1104/pp.110.171561
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1864589
handle
http://hdl.handle.net/1854/LU-1864589
date created
2011-08-01 19:26:46
date last changed
2011-08-02 08:23:41
@article{1864589,
  abstract     = {The phytopathogenic actinomycete Rhodococcus fascians drives its host to form a nutrient-rich niche by secreting a mixture of cytokinins that triggers plant cell division and shoot formation. The discrepancy between the relatively low amount of secreted cytokinins and the severe impact of R. fascians infection on plant development has puzzled researchers for a long time. Polyamine and transcript profiling of wild-type and cytokinin receptor mutant plants revealed that the bacterial cytokinins directly stimulated the biosynthesis of plant putrescine by activating arginine decarboxylase expression. Pharmacological experiments showed that the increased levels of putrescine contributed to the severity of the symptoms. Thus, putrescine functions as a secondary signal that impinges on the cytokinin-activated pathway, amplifying the hormone-induced changes that lead to the formation of a leafy gall. Exogenous putrescine and treatment with polyamine biosynthesis inhibitors combined with transcript and polyamine analyses of wild-type and mutant plants indicated that the direct target of both the bacterial cytokinins and plant putrescine was the expression of D3-type cyclins. Hence, the activated D-type cyclin/retinoblastoma/E2F transcription factor pathway integrates both external and internal hormonal signals, stimulating mitotic cell divisions and inducing pathological plant organogenesis.},
  author       = {Stes, Elisabeth and Biondi, Stefania and Holsters, Marcella and Vereecke, Danny},
  issn         = {0032-0889},
  journal      = {PLANT PHYSIOLOGY},
  keyword      = {BIOSYNTHESIS,GROWTH,THALIANA,CYTOKININ,CELL-CYCLE,POLYAMINE METABOLISM,SPERMIDINE SYNTHASE,INSERTIONAL MUTAGENESIS,GENE-EXPRESSION,SEED DEVELOPMENT},
  language     = {eng},
  number       = {2},
  pages        = {712--725},
  title        = {Bacterial and plant signal integration via D3-type cyclins enhances symptom development in the Arabidopsis-Rhodococcus fascians interaction},
  url          = {http://dx.doi.org/10.1104/pp.110.171561},
  volume       = {156},
  year         = {2011},
}

Chicago
Stes, Elisabeth, Stefania Biondi, Marcella Holsters, and Danny Vereecke. 2011. “Bacterial and Plant Signal Integration via D3-type Cyclins Enhances Symptom Development in the Arabidopsis-Rhodococcus Fascians Interaction.” Plant Physiology 156 (2): 712–725.
APA
Stes, E., Biondi, S., Holsters, M., & Vereecke, D. (2011). Bacterial and plant signal integration via D3-type cyclins enhances symptom development in the Arabidopsis-Rhodococcus fascians interaction. PLANT PHYSIOLOGY, 156(2), 712–725.
Vancouver
1.
Stes E, Biondi S, Holsters M, Vereecke D. Bacterial and plant signal integration via D3-type cyclins enhances symptom development in the Arabidopsis-Rhodococcus fascians interaction. PLANT PHYSIOLOGY. 2011;156(2):712–25.
MLA
Stes, Elisabeth, Stefania Biondi, Marcella Holsters, et al. “Bacterial and Plant Signal Integration via D3-type Cyclins Enhances Symptom Development in the Arabidopsis-Rhodococcus Fascians Interaction.” PLANT PHYSIOLOGY 156.2 (2011): 712–725. Print.