Advanced search

Rational development of new sleeping sickness drugs

(1997) CURRENT MEDICINAL CHEMISTRY. 4(6). p.359-384
Author
Organization
Abstract
Narrow activity spectrum and toxicological considerations are major shortcomings of the current therapeutics used for the treatment of sleeping sickness. During the last decennial rational drug design approaches have entered the field and have opened new horizons for the future treatment of Trypanosoma infections. This short review summarizes the present status of antitrypanosomal rational drug design with special focuss on gGAPDH as worked out in the authors' laboratory.
Keywords
S-ADENOSYLMETHIONINE DECARBOXYLASE, TRYPANOSOMA-BRUCEI-BRUCEI, GLYCOSOMAL GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE, GAMMA-GLUTAMYLCYSTEINE SYNTHETASE, MECHANISM-BASED INACTIVATION, ADENOSYL-L-METHIONINE, TRYPANOTHIONE REDUCTASE, AFRICAN TRYPANOSOMES, ORNITHINE DECARBOXYLASE, CRITHIDIA-FASCICULATA

Citation

Please use this url to cite or link to this publication:

Chicago
Van Calenbergh, Serge, and Piet Herdewijn. 1997. “Rational Development of New Sleeping Sickness Drugs.” Current Medicinal Chemistry 4 (6): 359–384.
APA
Van Calenbergh, S., & Herdewijn, P. (1997). Rational development of new sleeping sickness drugs. CURRENT MEDICINAL CHEMISTRY, 4(6), 359–384.
Vancouver
1.
Van Calenbergh S, Herdewijn P. Rational development of new sleeping sickness drugs. CURRENT MEDICINAL CHEMISTRY. 1997;4(6):359–84.
MLA
Van Calenbergh, Serge, and Piet Herdewijn. “Rational Development of New Sleeping Sickness Drugs.” CURRENT MEDICINAL CHEMISTRY 4.6 (1997): 359–384. Print.
@article{186264,
  abstract     = {Narrow activity spectrum and toxicological considerations are major shortcomings of the current therapeutics used for the treatment of sleeping sickness. During the last decennial rational drug design approaches have entered the field and have opened new horizons for the future treatment of Trypanosoma infections. This short review summarizes the present status of antitrypanosomal rational drug design with special focuss on gGAPDH as worked out in the authors' laboratory.},
  author       = {Van Calenbergh, Serge and Herdewijn, Piet},
  issn         = {0929-8673},
  journal      = {CURRENT MEDICINAL CHEMISTRY},
  keywords     = {S-ADENOSYLMETHIONINE DECARBOXYLASE,TRYPANOSOMA-BRUCEI-BRUCEI,GLYCOSOMAL GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE,GAMMA-GLUTAMYLCYSTEINE SYNTHETASE,MECHANISM-BASED INACTIVATION,ADENOSYL-L-METHIONINE,TRYPANOTHIONE REDUCTASE,AFRICAN TRYPANOSOMES,ORNITHINE DECARBOXYLASE,CRITHIDIA-FASCICULATA},
  language     = {eng},
  number       = {6},
  pages        = {359--384},
  title        = {Rational development of new sleeping sickness drugs},
  volume       = {4},
  year         = {1997},
}