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Impairment and impact of pain in female patients with Ehlers-Danlos syndrome: a comparative study with fibromyalgia and rheumatoid arthritis

Lies Rombaut UGent, Fransiska Malfait UGent, Anne De Paepe UGent, STEVEN RIMBAUT UGent, August Verbruggen UGent, Inge De Wandele UGent and Patrick Calders UGent (2011) ARTHRITIS AND RHEUMATISM. 63(7). p.1979-1987
abstract
Objective. The purpose of this study was to investigate functional impairment and the impact of pain in patients with Ehlers-Danlos syndrome, hypermobility type (EDS-HT), and to compare the burden of disease with that in women with fibromyalgia (FM) and rheumatoid arthritis (RA). Methods. A total of 206 female patients were compared (72 with EDS-HT, 69 with FM, and 65 with RA). Functional impairment was assessed with the Sickness Impact Profile (SIP), and the psychosocial impact of chronic pain was quantified with the Multidimensional Pain Inventory (MPI). Data on symptoms were collected. Results. SIP results showed clinically relevant health-related dysfunction in all groups. Significantly poorer physical, psychosocial, and overall function was found in the EDS-HT group compared with the RA group. In comparison with the FM group, the EDS-HT group reported similar physical and overall function, but better psychosocial function. T scores from the MPI revealed significantly higher levels of pain severity and life interference due to pain, and a lower level of perceived life control, in the EDS-HT group compared to the RA group. In contrast, the EDS-HT group showed significantly lower levels of pain severity, life interference, and affective distress in comparison with the FM group. Social support for help in coping with pain was similar between the 3 groups. Conclusion. EDS-HT is associated with a consistent burden of disease, similar to that of FM and worse than that of RA, as well as a broad impact of chronic pain on daily life, which needs to be addressed in the health care system.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
MUSCULOSKELETAL CONDITIONS, SF-36 HEALTH SURVEY, GENERAL-POPULATION, HYPERMOBILITY TYPE, SYNDROME EDS, BURDEN, INVENTORY, MANIFESTATIONS, CLASSIFICATION, QUALITY-OF-LIFE
journal title
ARTHRITIS AND RHEUMATISM
Arthritis Rheum.
volume
63
issue
7
pages
1979 - 1987
Web of Science type
Article
Web of Science id
000292809700026
JCR category
RHEUMATOLOGY
JCR impact factor
7.866 (2011)
JCR rank
3/29 (2011)
JCR quartile
1 (2011)
ISSN
0004-3591
DOI
10.1002/art.30337
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1860501
handle
http://hdl.handle.net/1854/LU-1860501
date created
2011-07-20 14:28:34
date last changed
2012-01-03 15:52:00
@article{1860501,
  abstract     = {Objective. The purpose of this study was to investigate functional impairment and the impact of pain in patients with Ehlers-Danlos syndrome, hypermobility type (EDS-HT), and to compare the burden of disease with that in women with fibromyalgia (FM) and rheumatoid arthritis (RA). 
Methods. A total of 206 female patients were compared (72 with EDS-HT, 69 with FM, and 65 with RA). Functional impairment was assessed with the Sickness Impact Profile (SIP), and the psychosocial impact of chronic pain was quantified with the Multidimensional Pain Inventory (MPI). Data on symptoms were collected. 
Results. SIP results showed clinically relevant health-related dysfunction in all groups. Significantly poorer physical, psychosocial, and overall function was found in the EDS-HT group compared with the RA group. In comparison with the FM group, the EDS-HT group reported similar physical and overall function, but better psychosocial function. T scores from the MPI revealed significantly higher levels of pain severity and life interference due to pain, and a lower level of perceived life control, in the EDS-HT group compared to the RA group. In contrast, the EDS-HT group showed significantly lower levels of pain severity, life interference, and affective distress in comparison with the FM group. Social support for help in coping with pain was similar between the 3 groups. 
Conclusion. EDS-HT is associated with a consistent burden of disease, similar to that of FM and worse than that of RA, as well as a broad impact of chronic pain on daily life, which needs to be addressed in the health care system.},
  author       = {Rombaut, Lies and Malfait, Fransiska and De Paepe, Anne and RIMBAUT, STEVEN and Verbruggen, August and De Wandele, Inge and Calders, Patrick},
  issn         = {0004-3591},
  journal      = {ARTHRITIS AND RHEUMATISM},
  keyword      = {MUSCULOSKELETAL CONDITIONS,SF-36 HEALTH SURVEY,GENERAL-POPULATION,HYPERMOBILITY TYPE,SYNDROME EDS,BURDEN,INVENTORY,MANIFESTATIONS,CLASSIFICATION,QUALITY-OF-LIFE},
  language     = {eng},
  number       = {7},
  pages        = {1979--1987},
  title        = {Impairment and impact of pain in female patients with Ehlers-Danlos syndrome: a comparative study with fibromyalgia and rheumatoid arthritis},
  url          = {http://dx.doi.org/10.1002/art.30337},
  volume       = {63},
  year         = {2011},
}

Chicago
Rombaut, Lies, Fransiska Malfait, Anne De Paepe, STEVEN RIMBAUT, August Verbruggen, Inge De Wandele, and Patrick Calders. 2011. “Impairment and Impact of Pain in Female Patients with Ehlers-Danlos Syndrome: a Comparative Study with Fibromyalgia and Rheumatoid Arthritis.” Arthritis and Rheumatism 63 (7): 1979–1987.
APA
Rombaut, L., Malfait, F., De Paepe, A., RIMBAUT, S., Verbruggen, A., De Wandele, I., & Calders, P. (2011). Impairment and impact of pain in female patients with Ehlers-Danlos syndrome: a comparative study with fibromyalgia and rheumatoid arthritis. ARTHRITIS AND RHEUMATISM, 63(7), 1979–1987.
Vancouver
1.
Rombaut L, Malfait F, De Paepe A, RIMBAUT S, Verbruggen A, De Wandele I, et al. Impairment and impact of pain in female patients with Ehlers-Danlos syndrome: a comparative study with fibromyalgia and rheumatoid arthritis. ARTHRITIS AND RHEUMATISM. 2011;63(7):1979–87.
MLA
Rombaut, Lies, Fransiska Malfait, Anne De Paepe, et al. “Impairment and Impact of Pain in Female Patients with Ehlers-Danlos Syndrome: a Comparative Study with Fibromyalgia and Rheumatoid Arthritis.” ARTHRITIS AND RHEUMATISM 63.7 (2011): 1979–1987. Print.