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Cascade of neural events leading from error commission to subsequent awareness revealed using EEG source imaging

Monica Dhar, Roeljan Wiersema UGent and Gilles Pourtois UGent (2011) PLOS ONE. 6(5).
abstract
The goal of the present study was to shed light on the respective contributions of three important action monitoring brain regions (i.e. cingulate cortex, insula, and orbitofrontal cortex) during the conscious detection of response errors. To this end, fourteen healthy adults performed a speeded Go/Nogo task comprising Nogo trials of varying levels of difficulty, designed to elicit aware and unaware errors. Error awareness was indicated by participants with a second key press after the target key press. Meanwhile, electromyogram (EMG) from the response hand was recorded in addition to high-density scalp electroencephalogram (EEG). In the EMG-locked grand averages, aware errors clearly elicited an error-related negativity (ERN) reflecting error detection, and a later error positivity (Pe) reflecting conscious error awareness. However, no Pe was recorded after unaware errors or hits. These results are in line with previous studies suggesting that error awareness is associated with generation of the Pe. Source localisation results confirmed that the posterior cingulate motor area was the main generator of the ERN. However, inverse solution results also point to the involvement of the left posterior insula during the time interval of the Pe, and hence error awareness. Moreover, consecutive to this insular activity, the right orbitofrontal cortex (OFC) was activated in response to aware and unaware errors but not in response to hits, consistent with the implication of this area in the evaluation of the value of an error. These results reveal a precise sequence of activations in these three non-overlapping brain regions following error commission, enabling a progressive differentiation between aware and unaware errors as a function of time elapsed, thanks to the involvement first of interoceptive or proprioceptive processes (left insula), later leading to the detection of a breach in the prepotent response mode (right OFC).
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
ANTERIOR CINGULATE CORTEX, MEDIAL FRONTAL-CORTEX, HUMAN ORBITOFRONTAL CORTEX, PREFRONTAL CORTEX, FUNCTIONAL-SIGNIFICANCE, BRAIN POTENTIALS, ANTISACCADE TASK, SOCIAL-BEHAVIOR, RESPONSE ERRORS, CORRECT TRIALS
journal title
PLOS ONE
PLoS One
volume
6
issue
5
article number
e19578
Web of Science type
Article
Web of Science id
000290256400027
JCR category
BIOLOGY
JCR impact factor
4.092 (2011)
JCR rank
12/84 (2011)
JCR quartile
1 (2011)
ISSN
1932-6203
DOI
10.1371/journal.pone.0019578
project
The integrative neuroscience of behavioral control (Neuroscience)
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1860039
handle
http://hdl.handle.net/1854/LU-1860039
date created
2011-07-15 16:18:15
date last changed
2016-12-21 15:41:52
@article{1860039,
  abstract     = {The goal of the present study was to shed light on the respective contributions of three important action monitoring brain regions (i.e. cingulate cortex, insula, and orbitofrontal cortex) during the conscious detection of response errors. To this end, fourteen healthy adults performed a speeded Go/Nogo task comprising Nogo trials of varying levels of difficulty, designed to elicit aware and unaware errors. Error awareness was indicated by participants with a second key press after the target key press. Meanwhile, electromyogram (EMG) from the response hand was recorded in addition to high-density scalp electroencephalogram (EEG). In the EMG-locked grand averages, aware errors clearly elicited an error-related negativity (ERN) reflecting error detection, and a later error positivity (Pe) reflecting conscious error awareness. However, no Pe was recorded after unaware errors or hits. These results are in line with previous studies suggesting that error awareness is associated with generation of the Pe. Source localisation results confirmed that the posterior cingulate motor area was the main generator of the ERN. However, inverse solution results also point to the involvement of the left posterior insula during the time interval of the Pe, and hence error awareness. Moreover, consecutive to this insular activity, the right orbitofrontal cortex (OFC) was activated in response to aware and unaware errors but not in response to hits, consistent with the implication of this area in the evaluation of the value of an error. These results reveal a precise sequence of activations in these three non-overlapping brain regions following error commission, enabling a progressive differentiation between aware and unaware errors as a function of time elapsed, thanks to the involvement first of interoceptive or proprioceptive processes (left insula), later leading to the detection of a breach in the prepotent response mode (right OFC).},
  articleno    = {e19578},
  author       = {Dhar, Monica and Wiersema, Roeljan and Pourtois, Gilles},
  issn         = {1932-6203},
  journal      = {PLOS ONE},
  keyword      = {ANTERIOR CINGULATE CORTEX,MEDIAL FRONTAL-CORTEX,HUMAN ORBITOFRONTAL CORTEX,PREFRONTAL CORTEX,FUNCTIONAL-SIGNIFICANCE,BRAIN POTENTIALS,ANTISACCADE TASK,SOCIAL-BEHAVIOR,RESPONSE ERRORS,CORRECT TRIALS},
  language     = {eng},
  number       = {5},
  title        = {Cascade of neural events leading from error commission to subsequent awareness revealed using EEG source imaging},
  url          = {http://dx.doi.org/10.1371/journal.pone.0019578},
  volume       = {6},
  year         = {2011},
}

Chicago
Dhar, Monica, Roeljan Wiersema, and Gilles Pourtois. 2011. “Cascade of Neural Events Leading from Error Commission to Subsequent Awareness Revealed Using EEG Source Imaging.” Plos One 6 (5).
APA
Dhar, M., Wiersema, R., & Pourtois, G. (2011). Cascade of neural events leading from error commission to subsequent awareness revealed using EEG source imaging. PLOS ONE, 6(5).
Vancouver
1.
Dhar M, Wiersema R, Pourtois G. Cascade of neural events leading from error commission to subsequent awareness revealed using EEG source imaging. PLOS ONE. 2011;6(5).
MLA
Dhar, Monica, Roeljan Wiersema, and Gilles Pourtois. “Cascade of Neural Events Leading from Error Commission to Subsequent Awareness Revealed Using EEG Source Imaging.” PLOS ONE 6.5 (2011): n. pag. Print.