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The host selects mucosal and luminal associations of coevolved gut microorganisms: a novel concept

Pieter Van den Abbeele UGent, Tom Van de Wiele UGent, Willy Verstraete UGent and Sam Possemiers UGent (2011) FEMS MICROBIOLOGY REVIEWS. 35(4). p.681-704
abstract
ong the human gastrointestinal tract, microorganisms are confronted with multiple barriers. Besides selective physical conditions, the epithelium is regularly replaced and covered with a protective mucus layer trapping immune molecules. Recent insights into host defense strategies show that the host selects the intestinal microbiota, particularly the mucosa-associated microbial community. In this context, humans coevolved with thousands of intestinal microbial species that have adapted to provide host benefits, while avoiding pathogenic behavior that might destabilize their host interaction. While mucosal microorganisms would be crucial for immunological priming, luminal microorganisms would be important for nutrient digestion. Further, we propose that the intestinal microorganisms also coevolved with each other, leading to coherently organized, resilient microbial associations. During disturbances, functionally redundant members become more abundant and are crucial for preserving community functionality. The outside of the mucus layer, where host defense molecules are more diluted, could serve as an environment where microorganisms are protected from disturbances in the lumen and from where they can recolonize the lumen after perturbations. This might explain the remarkable temporal stability of microbial communities. Finally, commensals that become renegade or a decreased exposure to essential coevolved microorganisms may cause particular health problems such as inflammatory bowel diseases, obesity or allergies.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
16S RIBOSOMAL-RNA, INNATE IMMUNE-SYSTEM, INFLAMMATORY-BOWEL-DISEASE, HUMAN INTESTINAL MICROBIOTA, GRADIENT GEL-ELECTROPHORESIS, BUTYRATE-PRODUCING BACTERIA, LACTOBACILLUS-RHAMNOSUS GG, ILEAL CROHNS-DISEASE, TOLL-LIKE RECEPTOR-3, T-CELL POLARIZATION, microbial communities, colon, symbiotic bacteria, Crohn's disease, gastrointestinal
journal title
FEMS MICROBIOLOGY REVIEWS
Fems Microbiol. Rev.
volume
35
issue
4
pages
681 - 704
Web of Science type
Review
Web of Science id
000291313100005
JCR category
MICROBIOLOGY
JCR impact factor
10.96 (2011)
JCR rank
6/111 (2011)
JCR quartile
1 (2011)
ISSN
0168-6445
DOI
10.1111/j.1574-6976.2011.00270.x
project
Biotechnology for a sustainable economy (Bio-Economy)
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1857966
handle
http://hdl.handle.net/1854/LU-1857966
date created
2011-07-13 10:52:18
date last changed
2013-02-27 12:59:22
@article{1857966,
  abstract     = {ong the human gastrointestinal tract, microorganisms are confronted with multiple barriers. Besides selective physical conditions, the epithelium is regularly replaced and covered with a protective mucus layer trapping immune molecules. Recent insights into host defense strategies show that the host selects the intestinal microbiota, particularly the mucosa-associated microbial community. In this context, humans coevolved with thousands of intestinal microbial species that have adapted to provide host benefits, while avoiding pathogenic behavior that might destabilize their host interaction. While mucosal microorganisms would be crucial for immunological priming, luminal microorganisms would be important for nutrient digestion. Further, we propose that the intestinal microorganisms also coevolved with each other, leading to coherently organized, resilient microbial associations. During disturbances, functionally redundant members become more abundant and are crucial for preserving community functionality. The outside of the mucus layer, where host defense molecules are more diluted, could serve as an environment where microorganisms are protected from disturbances in the lumen and from where they can recolonize the lumen after perturbations. This might explain the remarkable temporal stability of microbial communities. Finally, commensals that become renegade or a decreased exposure to essential coevolved microorganisms may cause particular health problems such as inflammatory bowel diseases, obesity or allergies.},
  author       = {Van den Abbeele, Pieter and Van de Wiele, Tom and Verstraete, Willy and Possemiers, Sam},
  issn         = {0168-6445},
  journal      = {FEMS MICROBIOLOGY REVIEWS},
  keyword      = {16S RIBOSOMAL-RNA,INNATE IMMUNE-SYSTEM,INFLAMMATORY-BOWEL-DISEASE,HUMAN INTESTINAL MICROBIOTA,GRADIENT GEL-ELECTROPHORESIS,BUTYRATE-PRODUCING BACTERIA,LACTOBACILLUS-RHAMNOSUS GG,ILEAL CROHNS-DISEASE,TOLL-LIKE RECEPTOR-3,T-CELL POLARIZATION,microbial communities,colon,symbiotic bacteria,Crohn's disease,gastrointestinal},
  language     = {eng},
  number       = {4},
  pages        = {681--704},
  title        = {The host selects mucosal and luminal associations of coevolved gut microorganisms: a novel concept},
  url          = {http://dx.doi.org/10.1111/j.1574-6976.2011.00270.x},
  volume       = {35},
  year         = {2011},
}

Chicago
Van den Abbeele, Pieter, Tom Van de Wiele, Willy Verstraete, and Sam Possemiers. 2011. “The Host Selects Mucosal and Luminal Associations of Coevolved Gut Microorganisms: a Novel Concept.” Fems Microbiology Reviews 35 (4): 681–704.
APA
Van den Abbeele, P., Van de Wiele, T., Verstraete, W., & Possemiers, S. (2011). The host selects mucosal and luminal associations of coevolved gut microorganisms: a novel concept. FEMS MICROBIOLOGY REVIEWS, 35(4), 681–704.
Vancouver
1.
Van den Abbeele P, Van de Wiele T, Verstraete W, Possemiers S. The host selects mucosal and luminal associations of coevolved gut microorganisms: a novel concept. FEMS MICROBIOLOGY REVIEWS. 2011;35(4):681–704.
MLA
Van den Abbeele, Pieter, Tom Van de Wiele, Willy Verstraete, et al. “The Host Selects Mucosal and Luminal Associations of Coevolved Gut Microorganisms: a Novel Concept.” FEMS MICROBIOLOGY REVIEWS 35.4 (2011): 681–704. Print.