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Biodegradable polyphosphazenes for drug delivery

(1997) MACROMOLECULAR SYMPOSIA. 123. p.103-112
Author
Organization
Abstract
Polyphosphazene derivatives having amino acid ester side groups were prepared by reaction of poly(dichlorophosphazene) with ethyl esters of amino acids. The in vitro degradation studies demonstrated that the rate of degradation depends on the nature of the amino acids. Introducing small amounts of hydrolytically sensitive groups such as depsipeptide ester or hydrolysis-catalysing moieties, such as histidine ethyl ester co-substituents, resulted in an increase of the degradation. The rate of hydrolytic degradation of the polyphosphazene material could be controlled by the content of the hydrolytically sensitive side groups or by blending hydrolysis-sensitive polymers with more stable derivatives. The results obtained from the in vivo implantation of biodegradable polyphosphazenes in mice indicate that the materials are very well tolerated by the animal body. Biodegradable polyphosphazenes have been used as matrix for the design of drug delivery systems. The rate of the in vitro release of mitomycin C from biodegradable polyphosphazenes can be controlled by changing the chemical composition of the polymer or by blending polymers of different chemical compositions.
Keywords
POLY(ORGANOPHOSPHAZENES), POLYMERS

Citation

Please use this url to cite or link to this publication:

MLA
Lemmouchi, Y, Etienne Schacht, Stephane Dejardin, et al. “Biodegradable Polyphosphazenes for Drug Delivery.” MACROMOLECULAR SYMPOSIA 123 (1997): 103–112. Print.
APA
Lemmouchi, Y, Schacht, E., Dejardin, S., Vandorpe, J., & Seymour, L. (1997). Biodegradable polyphosphazenes for drug delivery. MACROMOLECULAR SYMPOSIA, 123, 103–112. Presented at the 37th Microsymposium on Macromolecules (Bio)Degradable Polymers: Chemical, Biological and Environmental Aspects.
Chicago author-date
Lemmouchi, Y, Etienne Schacht, Stephane Dejardin, Joke Vandorpe, and L Seymour. 1997. “Biodegradable Polyphosphazenes for Drug Delivery.” Macromolecular Symposia 123: 103–112.
Chicago author-date (all authors)
Lemmouchi, Y, Etienne Schacht, Stephane Dejardin, Joke Vandorpe, and L Seymour. 1997. “Biodegradable Polyphosphazenes for Drug Delivery.” Macromolecular Symposia 123: 103–112.
Vancouver
1.
Lemmouchi Y, Schacht E, Dejardin S, Vandorpe J, Seymour L. Biodegradable polyphosphazenes for drug delivery. MACROMOLECULAR SYMPOSIA. 1997;123:103–12.
IEEE
[1]
Y. Lemmouchi, E. Schacht, S. Dejardin, J. Vandorpe, and L. Seymour, “Biodegradable polyphosphazenes for drug delivery,” MACROMOLECULAR SYMPOSIA, vol. 123, pp. 103–112, 1997.
@article{185590,
  abstract     = {Polyphosphazene derivatives having amino acid ester side groups were prepared by reaction of poly(dichlorophosphazene) with ethyl esters of amino acids. The in vitro degradation studies demonstrated that the rate of degradation depends on the nature of the amino acids. Introducing small amounts of hydrolytically sensitive groups such as depsipeptide ester or hydrolysis-catalysing moieties, such as histidine ethyl ester co-substituents, resulted in an increase of the degradation. The rate of hydrolytic degradation of the polyphosphazene material could be controlled by the content of the hydrolytically sensitive side groups or by blending hydrolysis-sensitive polymers with more stable derivatives. The results obtained from the in vivo implantation of biodegradable polyphosphazenes in mice indicate that the materials are very well tolerated by the animal body. Biodegradable polyphosphazenes have been used as matrix for the design of drug delivery systems. The rate of the in vitro release of mitomycin C from biodegradable polyphosphazenes can be controlled by changing the chemical composition of the polymer or by blending polymers of different chemical compositions.},
  author       = {Lemmouchi, Y and Schacht, Etienne and Dejardin, Stephane and Vandorpe, Joke and Seymour, L},
  issn         = {1022-1360},
  journal      = {MACROMOLECULAR SYMPOSIA},
  keywords     = {POLY(ORGANOPHOSPHAZENES),POLYMERS},
  language     = {eng},
  location     = {Prague, Czech Republic},
  pages        = {103--112},
  title        = {Biodegradable polyphosphazenes for drug delivery},
  url          = {http://dx.doi.org/10.1002/masy.19971230111},
  volume       = {123},
  year         = {1997},
}

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