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Inositol trisphosphate-induced Ca2+ signaling modulates auxin transport and PIN polarity

Jing Zhang (UGent) , Steffen Vanneste (UGent) , Philip B Brewer, Marta Michniewicz, Peter Grones (UGent) , Jürgen Kleine-Vehn (UGent) , Christian Löfke, Thomas Teichmann, Agnieszka Bielach (UGent) , Bernard Cannoot (UGent) , et al.
(2011) DEVELOPMENTAL CELL. 20(6). p.855-866
Author
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Abstract
The phytohormone auxin is an important determinant of plant development. Directional auxin flow within tissues depends on polar localization of PIN auxin transporters. To explore regulation of PIN-mediated auxin transport, we screened for suppressors of PIN1 overexpression (supo) and identified an inositol polyphosphate 1-phosphatase mutant (supo1), with elevated inositol trisphosphate (InsP(3)) and cytosolic Ca2+ levels. Pharmacological and genetic increases in InsP(3) or Ca2+ levels also suppressed the PIN1 gain-of-function phenotypes and caused defects in basal PIN localization, auxin transport and auxin-mediated development. In contrast, the reductions in InsP(3) levels and Ca2+ signaling antagonized the effects of the supo1 mutation and disrupted preferentially apical PIN localization. InsP(3) and Ca2+ are evolutionarily conserved second messengers involved in various cellular functions, particularly stress responses. Our findings implicate them as modifiers of cell polarity and polar auxin transport, and highlight a potential integration point through which Ca2+ signaling-related stimuli could influence auxin-mediated development.
Keywords
ENDOPLASMIC-RETICULUM, ARABIDOPSIS-THALIANA, POLYPHOSPHATE 1-PHOSPHATASE, PLANT DEVELOPMENT, CALCIUM PUMPS, EFFLUX CARRIER, NEGATIVE REGULATOR, ABSCISIC-ACID, ADVENTITIOUS ROOT-FORMATION, PROTEIN

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Citation

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MLA
Zhang, Jing, et al. “Inositol Trisphosphate-Induced Ca2+ Signaling Modulates Auxin Transport and PIN Polarity.” DEVELOPMENTAL CELL, vol. 20, no. 6, 2011, pp. 855–66, doi:10.1016/j.devcel.2011.05.013.
APA
Zhang, J., Vanneste, S., Brewer, P. B., Michniewicz, M., Grones, P., Kleine-Vehn, J., … Friml, J. (2011). Inositol trisphosphate-induced Ca2+ signaling modulates auxin transport and PIN polarity. DEVELOPMENTAL CELL, 20(6), 855–866. https://doi.org/10.1016/j.devcel.2011.05.013
Chicago author-date
Zhang, Jing, Steffen Vanneste, Philip B Brewer, Marta Michniewicz, Peter Grones, Jürgen Kleine-Vehn, Christian Löfke, et al. 2011. “Inositol Trisphosphate-Induced Ca2+ Signaling Modulates Auxin Transport and PIN Polarity.” DEVELOPMENTAL CELL 20 (6): 855–66. https://doi.org/10.1016/j.devcel.2011.05.013.
Chicago author-date (all authors)
Zhang, Jing, Steffen Vanneste, Philip B Brewer, Marta Michniewicz, Peter Grones, Jürgen Kleine-Vehn, Christian Löfke, Thomas Teichmann, Agnieszka Bielach, Bernard Cannoot, Klára Hoyerová, Xu Chen, Hong-Wei Xue, Eva Benkova, Eva Zazímalová, and Jiri Friml. 2011. “Inositol Trisphosphate-Induced Ca2+ Signaling Modulates Auxin Transport and PIN Polarity.” DEVELOPMENTAL CELL 20 (6): 855–866. doi:10.1016/j.devcel.2011.05.013.
Vancouver
1.
Zhang J, Vanneste S, Brewer PB, Michniewicz M, Grones P, Kleine-Vehn J, et al. Inositol trisphosphate-induced Ca2+ signaling modulates auxin transport and PIN polarity. DEVELOPMENTAL CELL. 2011;20(6):855–66.
IEEE
[1]
J. Zhang et al., “Inositol trisphosphate-induced Ca2+ signaling modulates auxin transport and PIN polarity,” DEVELOPMENTAL CELL, vol. 20, no. 6, pp. 855–866, 2011.
@article{1854197,
  abstract     = {{The phytohormone auxin is an important determinant of plant development. Directional auxin flow within tissues depends on polar localization of PIN auxin transporters. To explore regulation of PIN-mediated auxin transport, we screened for suppressors of PIN1 overexpression (supo) and identified an inositol polyphosphate 1-phosphatase mutant (supo1), with elevated inositol trisphosphate (InsP(3)) and cytosolic Ca2+ levels. Pharmacological and genetic increases in InsP(3) or Ca2+ levels also suppressed the PIN1 gain-of-function phenotypes and caused defects in basal PIN localization, auxin transport and auxin-mediated development. In contrast, the reductions in InsP(3) levels and Ca2+ signaling antagonized the effects of the supo1 mutation and disrupted preferentially apical PIN localization. InsP(3) and Ca2+ are evolutionarily conserved second messengers involved in various cellular functions, particularly stress responses. Our findings implicate them as modifiers of cell polarity and polar auxin transport, and highlight a potential integration point through which Ca2+ signaling-related stimuli could influence auxin-mediated development.}},
  author       = {{Zhang, Jing and Vanneste, Steffen and Brewer, Philip B and Michniewicz, Marta and Grones, Peter and Kleine-Vehn, Jürgen and Löfke, Christian and Teichmann, Thomas and Bielach, Agnieszka and Cannoot, Bernard and Hoyerová, Klára and Chen, Xu and Xue, Hong-Wei and Benkova, Eva and Zazímalová, Eva and Friml, Jiri}},
  issn         = {{1534-5807}},
  journal      = {{DEVELOPMENTAL CELL}},
  keywords     = {{ENDOPLASMIC-RETICULUM,ARABIDOPSIS-THALIANA,POLYPHOSPHATE 1-PHOSPHATASE,PLANT DEVELOPMENT,CALCIUM PUMPS,EFFLUX CARRIER,NEGATIVE REGULATOR,ABSCISIC-ACID,ADVENTITIOUS ROOT-FORMATION,PROTEIN}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{855--866}},
  title        = {{Inositol trisphosphate-induced Ca2+ signaling modulates auxin transport and PIN polarity}},
  url          = {{http://doi.org/10.1016/j.devcel.2011.05.013}},
  volume       = {{20}},
  year         = {{2011}},
}
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