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Inositol trisphosphate-induced Ca2+ signaling modulates auxin transport and PIN polarity

Jing Zhang UGent, Steffen Vanneste UGent, Philip B Brewer, Marta Michniewicz, Peter Grones UGent, Jürgen Kleine-Vehn UGent, Christian Löfke, Thomas Teichmann, Agnieszka Bielach UGent and Bernard Cannoot UGent, et al. (2011) DEVELOPMENTAL CELL. 20(6). p.855-866
abstract
The phytohormone auxin is an important determinant of plant development. Directional auxin flow within tissues depends on polar localization of PIN auxin transporters. To explore regulation of PIN-mediated auxin transport, we screened for suppressors of PIN1 overexpression (supo) and identified an inositol polyphosphate 1-phosphatase mutant (supo1), with elevated inositol trisphosphate (InsP(3)) and cytosolic Ca2+ levels. Pharmacological and genetic increases in InsP(3) or Ca2+ levels also suppressed the PIN1 gain-of-function phenotypes and caused defects in basal PIN localization, auxin transport and auxin-mediated development. In contrast, the reductions in InsP(3) levels and Ca2+ signaling antagonized the effects of the supo1 mutation and disrupted preferentially apical PIN localization. InsP(3) and Ca2+ are evolutionarily conserved second messengers involved in various cellular functions, particularly stress responses. Our findings implicate them as modifiers of cell polarity and polar auxin transport, and highlight a potential integration point through which Ca2+ signaling-related stimuli could influence auxin-mediated development.
Please use this url to cite or link to this publication:
author
organization
alternative title
Inositol trisphosphate-induced Ca(2+) signaling modulates auxin transport and PIN polarity
year
type
journalArticle (original)
publication status
published
subject
keyword
ENDOPLASMIC-RETICULUM, ARABIDOPSIS-THALIANA, POLYPHOSPHATE 1-PHOSPHATASE, PLANT DEVELOPMENT, CALCIUM PUMPS, EFFLUX CARRIER, NEGATIVE REGULATOR, ABSCISIC-ACID, ADVENTITIOUS ROOT-FORMATION, PROTEIN
journal title
DEVELOPMENTAL CELL
Dev. Cell
volume
20
issue
6
pages
855 - 866
Web of Science type
Article
Web of Science id
000291763500013
JCR category
DEVELOPMENTAL BIOLOGY
JCR impact factor
14.03 (2011)
JCR rank
2/40 (2011)
JCR quartile
1 (2011)
ISSN
1534-5807
DOI
10.1016/j.devcel.2011.05.013
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1854197
handle
http://hdl.handle.net/1854/LU-1854197
date created
2011-07-06 17:29:21
date last changed
2011-08-04 13:48:09
@article{1854197,
  abstract     = {The phytohormone auxin is an important determinant of plant development. Directional auxin flow within tissues depends on polar localization of PIN auxin transporters. To explore regulation of PIN-mediated auxin transport, we screened for suppressors of PIN1 overexpression (supo) and identified an inositol polyphosphate 1-phosphatase mutant (supo1), with elevated inositol trisphosphate (InsP(3)) and cytosolic Ca2+ levels. Pharmacological and genetic increases in InsP(3) or Ca2+ levels also suppressed the PIN1 gain-of-function phenotypes and caused defects in basal PIN localization, auxin transport and auxin-mediated development. In contrast, the reductions in InsP(3) levels and Ca2+ signaling antagonized the effects of the supo1 mutation and disrupted preferentially apical PIN localization. InsP(3) and Ca2+ are evolutionarily conserved second messengers involved in various cellular functions, particularly stress responses. Our findings implicate them as modifiers of cell polarity and polar auxin transport, and highlight a potential integration point through which Ca2+ signaling-related stimuli could influence auxin-mediated development.},
  author       = {Zhang, Jing and Vanneste, Steffen and Brewer, Philip B and Michniewicz, Marta and Grones, Peter and Kleine-Vehn, J{\"u}rgen and L{\"o}fke, Christian and Teichmann, Thomas and Bielach, Agnieszka and Cannoot, Bernard and Hoyerov{\'a}, Kl{\'a}ra and Chen, Xu and Xue, Hong-Wei and Benkova, Eva and Zaz{\'i}malov{\'a}, Eva and Friml, Jiri},
  issn         = {1534-5807},
  journal      = {DEVELOPMENTAL CELL},
  keyword      = {ENDOPLASMIC-RETICULUM,ARABIDOPSIS-THALIANA,POLYPHOSPHATE 1-PHOSPHATASE,PLANT DEVELOPMENT,CALCIUM PUMPS,EFFLUX CARRIER,NEGATIVE REGULATOR,ABSCISIC-ACID,ADVENTITIOUS ROOT-FORMATION,PROTEIN},
  language     = {eng},
  number       = {6},
  pages        = {855--866},
  title        = {Inositol trisphosphate-induced Ca2+ signaling modulates auxin transport and PIN polarity},
  url          = {http://dx.doi.org/10.1016/j.devcel.2011.05.013},
  volume       = {20},
  year         = {2011},
}

Chicago
Zhang, Jing, Steffen Vanneste, Philip B Brewer, Marta Michniewicz, Peter Grones, Jürgen Kleine-Vehn, Christian Löfke, et al. 2011. “Inositol Trisphosphate-induced Ca2+ Signaling Modulates Auxin Transport and PIN Polarity.” Developmental Cell 20 (6): 855–866.
APA
Zhang, Jing, Vanneste, S., Brewer, P. B., Michniewicz, M., Grones, P., Kleine-Vehn, J., Löfke, C., et al. (2011). Inositol trisphosphate-induced Ca2+ signaling modulates auxin transport and PIN polarity. DEVELOPMENTAL CELL, 20(6), 855–866.
Vancouver
1.
Zhang J, Vanneste S, Brewer PB, Michniewicz M, Grones P, Kleine-Vehn J, et al. Inositol trisphosphate-induced Ca2+ signaling modulates auxin transport and PIN polarity. DEVELOPMENTAL CELL. 2011;20(6):855–66.
MLA
Zhang, Jing, Steffen Vanneste, Philip B Brewer, et al. “Inositol Trisphosphate-induced Ca2+ Signaling Modulates Auxin Transport and PIN Polarity.” DEVELOPMENTAL CELL 20.6 (2011): 855–866. Print.