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A mutually inhibitory interaction between Auxin and Cytokinin specifies vascular pattern in roots

Anthony Bishopp, Hanna Help, Sedeer El-Showk, Dolf Weijers, Ben Scheres, Jiri Friml UGent, Eva Benkova UGent, Ari Pekka Mähönen and Ykä Helariutta (2011) CURRENT BIOLOGY. 21(11). p.917-926
abstract
Background: Whereas the majority of animals develop toward a predetermined body plan, plants show iterative growth and continually produce new organs and structures from actively dividing meristems. This raises an intriguing question: How are these newly developed organs patterned? In Arabidopsis embryos, radial symmetry is broken by the bisymmetric specification of the cotyledons in the apical domain. Subsequently, this bisymmetry is propagated to the root promeristem. Results: Here we present a mutually inhibitory feedback loop between auxin and cytokinin that sets distinct boundaries of hormonal output. Cytokinins promote the bisymmetric distribution of the PIN-FORMED (PIN) auxin efflux proteins, which channel auxin toward a central domain. High auxin promotes transcription of the cytokinin signaling inhibitor AHP6, which closes the interaction loop. This bisymmetric auxin response domain specifies the differentiation of protoxylem in a bisymmetric pattern. In embryonic roots, cytokinin is required to translate a bisymmetric auxin response in the cotyledons to a bisymmetric vascular pattern in the root promeristem. Conclusions: Our results present an interactive feedback loop between hormonal signaling and transport by which small biases in hormonal input are propagated into distinct signaling domains to specify the vascular pattern in the root meristem. It is an intriguing possibility that such a mechanism could transform radial patterns and allow continuous vascular connections between other newly emerging organs.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
EMBRYO, EFFLUX, EMBRYOGENESIS, GENE FAMILY, HORMONAL-CONTROL, MERISTEM ACTIVITY, ARABIDOPSIS ROOT, CLASS IIIHD-ZIP, CUP-SHAPED-COTYLEDON, STEM-CELL NICHE
journal title
CURRENT BIOLOGY
Curr. Biol.
volume
21
issue
11
pages
917 - 926
Web of Science type
Article
Web of Science id
000291668100015
JCR category
BIOCHEMISTRY & MOLECULAR BIOLOGY
JCR impact factor
9.647 (2011)
JCR rank
18/286 (2011)
JCR quartile
1 (2011)
ISSN
0960-9822
DOI
10.1016/j.cub.2011.04.017
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1854186
handle
http://hdl.handle.net/1854/LU-1854186
date created
2011-07-06 17:29:15
date last changed
2011-08-03 13:22:00
@article{1854186,
  abstract     = {Background: Whereas the majority of animals develop toward a predetermined body plan, plants show iterative growth and continually produce new organs and structures from actively dividing meristems. This raises an intriguing question: How are these newly developed organs patterned? In Arabidopsis embryos, radial symmetry is broken by the bisymmetric specification of the cotyledons in the apical domain. Subsequently, this bisymmetry is propagated to the root promeristem. Results: Here we present a mutually inhibitory feedback loop between auxin and cytokinin that sets distinct boundaries of hormonal output. Cytokinins promote the bisymmetric distribution of the PIN-FORMED (PIN) auxin efflux proteins, which channel auxin toward a central domain. High auxin promotes transcription of the cytokinin signaling inhibitor AHP6, which closes the interaction loop. This bisymmetric auxin response domain specifies the differentiation of protoxylem in a bisymmetric pattern. In embryonic roots, cytokinin is required to translate a bisymmetric auxin response in the cotyledons to a bisymmetric vascular pattern in the root promeristem. Conclusions: Our results present an interactive feedback loop between hormonal signaling and transport by which small biases in hormonal input are propagated into distinct signaling domains to specify the vascular pattern in the root meristem. It is an intriguing possibility that such a mechanism could transform radial patterns and allow continuous vascular connections between other newly emerging organs.},
  author       = {Bishopp, Anthony and Help, Hanna and El-Showk, Sedeer and Weijers, Dolf and Scheres, Ben and Friml, Jiri and Benkova, Eva and M{\"a}h{\"o}nen, Ari Pekka and Helariutta, Yk{\"a}},
  issn         = {0960-9822},
  journal      = {CURRENT BIOLOGY},
  keyword      = {EMBRYO,EFFLUX,EMBRYOGENESIS,GENE FAMILY,HORMONAL-CONTROL,MERISTEM ACTIVITY,ARABIDOPSIS ROOT,CLASS IIIHD-ZIP,CUP-SHAPED-COTYLEDON,STEM-CELL NICHE},
  language     = {eng},
  number       = {11},
  pages        = {917--926},
  title        = {A mutually inhibitory interaction between Auxin and Cytokinin specifies vascular pattern in roots},
  url          = {http://dx.doi.org/10.1016/j.cub.2011.04.017},
  volume       = {21},
  year         = {2011},
}

Chicago
Bishopp, Anthony, Hanna Help, Sedeer El-Showk, Dolf Weijers, Ben Scheres, Jiri Friml, Eva Benkova, Ari Pekka Mähönen, and Ykä Helariutta. 2011. “A Mutually Inhibitory Interaction Between Auxin and Cytokinin Specifies Vascular Pattern in Roots.” Current Biology 21 (11): 917–926.
APA
Bishopp, A., Help, H., El-Showk, S., Weijers, D., Scheres, B., Friml, J., Benkova, E., et al. (2011). A mutually inhibitory interaction between Auxin and Cytokinin specifies vascular pattern in roots. CURRENT BIOLOGY, 21(11), 917–926.
Vancouver
1.
Bishopp A, Help H, El-Showk S, Weijers D, Scheres B, Friml J, et al. A mutually inhibitory interaction between Auxin and Cytokinin specifies vascular pattern in roots. CURRENT BIOLOGY. 2011;21(11):917–26.
MLA
Bishopp, Anthony, Hanna Help, Sedeer El-Showk, et al. “A Mutually Inhibitory Interaction Between Auxin and Cytokinin Specifies Vascular Pattern in Roots.” CURRENT BIOLOGY 21.11 (2011): 917–926. Print.