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Extracorporeally irradiated autografts for the treatment of bone tumours: tips and tricks

Bart Poffyn UGent, Gwen Sys UGent, ALEXANDER MULLIEZ UGent, GEORGES VAN MAELE UGent, Luc Van Hoorebeke UGent, Ramses Forsyth UGent and Dirk Uyttendaele UGent (2011) INTERNATIONAL ORTHOPAEDICS. 35(6). p.889-895
abstract
We retrospectively reviewed 107 patients with 108 malignant or locally aggressive bone tumours treated between 1978 and 2009 by extracorporeal irradiation with 300 Gy to eradicate the tumour, and reimplantation of the bone as an orthotopic autograft. Patient subgroups were defined according to resection type. We describe the local recurrence rate, the graft infection rate and the factors affecting graft healing and graft survival. No local recurrences were detected in the irradiated grafts. At five-year follow-up, graft healing had occurred in 64% of patients, providing a stable and lasting reconstruction. For various reasons, 11% of grafts were removed, although no single factor was predictive of failure. All patient subgroups had comparable results. Early infection predicted the development of pseudarthrosis. Pelvic reconstructions had a worse graft survival. Rigid fixation and bridging of the graft appeared to be important technical points.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
ENDOPROSTHESES, REPLACEMENT, RECONSTRUCTION, REIMPLANTATION, ALLOGRAFTS, LIMB SALVAGE SURGERY, RESECTION, GRAFTS, KNEE, EXPERIENCE
journal title
INTERNATIONAL ORTHOPAEDICS
Int. Orthop.
volume
35
issue
6
pages
889 - 895
Web of Science type
Article
Web of Science id
000291061000015
JCR category
ORTHOPEDICS
JCR impact factor
2.025 (2011)
JCR rank
22/63 (2011)
JCR quartile
2 (2011)
ISSN
0341-2695
DOI
10.1007/s00264-010-1098-1
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1852552
handle
http://hdl.handle.net/1854/LU-1852552
date created
2011-07-05 10:09:54
date last changed
2011-07-13 14:47:50
@article{1852552,
  abstract     = {We retrospectively reviewed 107 patients with 108 malignant or locally aggressive bone tumours treated between 1978 and 2009 by extracorporeal irradiation with 300 Gy to eradicate the tumour, and reimplantation of the bone as an orthotopic autograft. Patient subgroups were defined according to resection type. We describe the local recurrence rate, the graft infection rate and the factors affecting graft healing and graft survival. No local recurrences were detected in the irradiated grafts. At five-year follow-up, graft healing had occurred in 64\% of patients, providing a stable and lasting reconstruction. For various reasons, 11\% of grafts were removed, although no single factor was predictive of failure. All patient subgroups had comparable results. Early infection predicted the development of pseudarthrosis. Pelvic reconstructions had a worse graft survival. Rigid fixation and bridging of the graft appeared to be important technical points.},
  author       = {Poffyn, Bart and Sys, Gwen and MULLIEZ, ALEXANDER and VAN MAELE, GEORGES and Van Hoorebeke, Luc and Forsyth, Ramses and Uyttendaele, Dirk},
  issn         = {0341-2695},
  journal      = {INTERNATIONAL ORTHOPAEDICS},
  keyword      = {ENDOPROSTHESES,REPLACEMENT,RECONSTRUCTION,REIMPLANTATION,ALLOGRAFTS,LIMB SALVAGE SURGERY,RESECTION,GRAFTS,KNEE,EXPERIENCE},
  language     = {eng},
  number       = {6},
  pages        = {889--895},
  title        = {Extracorporeally irradiated autografts for the treatment of bone tumours: tips and tricks},
  url          = {http://dx.doi.org/10.1007/s00264-010-1098-1},
  volume       = {35},
  year         = {2011},
}

Chicago
POFFYN, BART, Gwen Sys, ALEXANDER MULLIEZ, Georges Van Maele, Luc Van Hoorebeke, Ramses Forsyth, and Dirk Uyttendaele. 2011. “Extracorporeally Irradiated Autografts for the Treatment of Bone Tumours: Tips and Tricks.” International Orthopaedics 35 (6): 889–895.
APA
POFFYN, B., Sys, G., MULLIEZ, A., Van Maele, G., Van Hoorebeke, L., Forsyth, R., & Uyttendaele, D. (2011). Extracorporeally irradiated autografts for the treatment of bone tumours: tips and tricks. INTERNATIONAL ORTHOPAEDICS, 35(6), 889–895.
Vancouver
1.
POFFYN B, Sys G, MULLIEZ A, Van Maele G, Van Hoorebeke L, Forsyth R, et al. Extracorporeally irradiated autografts for the treatment of bone tumours: tips and tricks. INTERNATIONAL ORTHOPAEDICS. 2011;35(6):889–95.
MLA
POFFYN, BART, Gwen Sys, ALEXANDER MULLIEZ, et al. “Extracorporeally Irradiated Autografts for the Treatment of Bone Tumours: Tips and Tricks.” INTERNATIONAL ORTHOPAEDICS 35.6 (2011): 889–895. Print.