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Extracorporeally irradiated autografts for the treatment of bone tumours: tips and tricks

(2011) INTERNATIONAL ORTHOPAEDICS. 35(6). p.889-895
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Abstract
We retrospectively reviewed 107 patients with 108 malignant or locally aggressive bone tumours treated between 1978 and 2009 by extracorporeal irradiation with 300 Gy to eradicate the tumour, and reimplantation of the bone as an orthotopic autograft. Patient subgroups were defined according to resection type. We describe the local recurrence rate, the graft infection rate and the factors affecting graft healing and graft survival. No local recurrences were detected in the irradiated grafts. At five-year follow-up, graft healing had occurred in 64% of patients, providing a stable and lasting reconstruction. For various reasons, 11% of grafts were removed, although no single factor was predictive of failure. All patient subgroups had comparable results. Early infection predicted the development of pseudarthrosis. Pelvic reconstructions had a worse graft survival. Rigid fixation and bridging of the graft appeared to be important technical points.
Keywords
ENDOPROSTHESES, REPLACEMENT, RECONSTRUCTION, REIMPLANTATION, ALLOGRAFTS, LIMB SALVAGE SURGERY, RESECTION, GRAFTS, KNEE, EXPERIENCE

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Chicago
Poffyn, Bart, Gwen Sys, Alexander Mulliez, GEORGES VAN MAELE, Luc Van Hoorebeke, Ramses Forsyth, and Dirk Uyttendaele. 2011. “Extracorporeally Irradiated Autografts for the Treatment of Bone Tumours: Tips and Tricks.” International Orthopaedics 35 (6): 889–895.
APA
Poffyn, Bart, Sys, G., Mulliez, A., VAN MAELE, G., Van Hoorebeke, L., Forsyth, R., & Uyttendaele, D. (2011). Extracorporeally irradiated autografts for the treatment of bone tumours: tips and tricks. INTERNATIONAL ORTHOPAEDICS, 35(6), 889–895.
Vancouver
1.
Poffyn B, Sys G, Mulliez A, VAN MAELE G, Van Hoorebeke L, Forsyth R, et al. Extracorporeally irradiated autografts for the treatment of bone tumours: tips and tricks. INTERNATIONAL ORTHOPAEDICS. 2011;35(6):889–95.
MLA
Poffyn, Bart, Gwen Sys, Alexander Mulliez, et al. “Extracorporeally Irradiated Autografts for the Treatment of Bone Tumours: Tips and Tricks.” INTERNATIONAL ORTHOPAEDICS 35.6 (2011): 889–895. Print.
@article{1852552,
  abstract     = {We retrospectively reviewed 107 patients with 108 malignant or locally aggressive bone tumours treated between 1978 and 2009 by extracorporeal irradiation with 300 Gy to eradicate the tumour, and reimplantation of the bone as an orthotopic autograft. Patient subgroups were defined according to resection type. We describe the local recurrence rate, the graft infection rate and the factors affecting graft healing and graft survival. No local recurrences were detected in the irradiated grafts. At five-year follow-up, graft healing had occurred in 64\% of patients, providing a stable and lasting reconstruction. For various reasons, 11\% of grafts were removed, although no single factor was predictive of failure. All patient subgroups had comparable results. Early infection predicted the development of pseudarthrosis. Pelvic reconstructions had a worse graft survival. Rigid fixation and bridging of the graft appeared to be important technical points.},
  author       = {Poffyn, Bart and Sys, Gwen and Mulliez, Alexander and VAN MAELE, GEORGES and Van Hoorebeke, Luc and Forsyth, Ramses and Uyttendaele, Dirk},
  issn         = {0341-2695},
  journal      = {INTERNATIONAL ORTHOPAEDICS},
  keyword      = {ENDOPROSTHESES,REPLACEMENT,RECONSTRUCTION,REIMPLANTATION,ALLOGRAFTS,LIMB SALVAGE SURGERY,RESECTION,GRAFTS,KNEE,EXPERIENCE},
  language     = {eng},
  number       = {6},
  pages        = {889--895},
  title        = {Extracorporeally irradiated autografts for the treatment of bone tumours: tips and tricks},
  url          = {http://dx.doi.org/10.1007/s00264-010-1098-1},
  volume       = {35},
  year         = {2011},
}

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