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Temperature-switchable assembly of supramolecular virus-polymer complexes

Mauri A Kostiainen, Christian Pietsch, Richard Hoogenboom UGent, Roeland JM Nolte and Jeroen JLM Cornelissen (2011) ADVANCED FUNCTIONAL MATERIALS. 21(11). p.2012-2019
abstract
Here a method is presented for the temperature-switchable assembly of viral particles into large hierarchical complexes. Dual-functional diblock copolymers consisting of poly(diethyleneglycol methyl ether methacrylate) (poly(DEGMA)) and poly((2-dimethylamino) ethyl methacrylate) (poly(DMAEMA)) blocks self-assemble electrostatically with cowpea chlorotic mottle virus (CCMV) particles into micrometer-sized objects as a function of temperature. The poly(DMAEMA) block carries a positive charge, which can interact electrostatically with the negatively charged outer surface of the CCMV capsid. When the solution temperature is increased above 40 degrees C, to cross the cloud point temperature (T(cp)) of the DEGMA block, the polymer chains collapse on the surface of the virus particle, which makes them partially hydrophobic, and consequently causes the formation of large hierarchical assemblies. Disassembly of the virus-polymer complexes can be induced by reducing the solution temperature below the T(cp), which allows the poly(DEGMA) blocks to rehydrate and free virus particles to be released. The assembly process is fully reversible and can sustain several heating-cooling cycles. Importantly, this method relies on reversible supramolecular interactions and therefore avoids the irreversible covalent modification of the particle surface. This study illustrates the potential of temperature-responsive polymers for controlled binding and releasing of virus particles.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
FRAGMENTATION CHAIN-TRANSFER, CHLOROTIC MOTTLE VIRUS, STIMULI-RESPONSIVE POLYMER, GOLD NANOPARTICLES, RADICAL POLYMERIZATION, POLY(ETHYLENE OXIDE), MESOGLOBULAR PHASE, DILUTE-SOLUTIONS, RAFT PROCESS, DNA-BINDING
journal title
ADVANCED FUNCTIONAL MATERIALS
Adv. Funct. Mater.
volume
21
issue
11
pages
2012 - 2019
Web of Science type
Article
Web of Science id
000291450000007
JCR category
MATERIALS SCIENCE, MULTIDISCIPLINARY
JCR impact factor
10.179 (2011)
JCR rank
10/229 (2011)
JCR quartile
1 (2011)
ISSN
1616-301X
DOI
10.1002/adfm.201002597
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1851519
handle
http://hdl.handle.net/1854/LU-1851519
date created
2011-07-01 16:21:50
date last changed
2016-12-19 15:42:17
@article{1851519,
  abstract     = {Here a method is presented for the temperature-switchable assembly of viral particles into large hierarchical complexes. Dual-functional diblock copolymers consisting of poly(diethyleneglycol methyl ether methacrylate) (poly(DEGMA)) and poly((2-dimethylamino) ethyl methacrylate) (poly(DMAEMA)) blocks self-assemble electrostatically with cowpea chlorotic mottle virus (CCMV) particles into micrometer-sized objects as a function of temperature. The poly(DMAEMA) block carries a positive charge, which can interact electrostatically with the negatively charged outer surface of the CCMV capsid. When the solution temperature is increased above 40 degrees C, to cross the cloud point temperature (T(cp)) of the DEGMA block, the polymer chains collapse on the surface of the virus particle, which makes them partially hydrophobic, and consequently causes the formation of large hierarchical assemblies. Disassembly of the virus-polymer complexes can be induced by reducing the solution temperature below the T(cp), which allows the poly(DEGMA) blocks to rehydrate and free virus particles to be released. The assembly process is fully reversible and can sustain several heating-cooling cycles. Importantly, this method relies on reversible supramolecular interactions and therefore avoids the irreversible covalent modification of the particle surface. This study illustrates the potential of temperature-responsive polymers for controlled binding and releasing of virus particles.},
  author       = {Kostiainen, Mauri A and Pietsch, Christian and Hoogenboom, Richard and Nolte, Roeland JM and Cornelissen, Jeroen JLM},
  issn         = {1616-301X},
  journal      = {ADVANCED FUNCTIONAL MATERIALS},
  keyword      = {FRAGMENTATION CHAIN-TRANSFER,CHLOROTIC MOTTLE VIRUS,STIMULI-RESPONSIVE POLYMER,GOLD NANOPARTICLES,RADICAL POLYMERIZATION,POLY(ETHYLENE OXIDE),MESOGLOBULAR PHASE,DILUTE-SOLUTIONS,RAFT PROCESS,DNA-BINDING},
  language     = {eng},
  number       = {11},
  pages        = {2012--2019},
  title        = {Temperature-switchable assembly of supramolecular virus-polymer complexes},
  url          = {http://dx.doi.org/10.1002/adfm.201002597},
  volume       = {21},
  year         = {2011},
}

Chicago
Kostiainen, Mauri A, Christian Pietsch, Richard Hoogenboom, Roeland JM Nolte, and Jeroen JLM Cornelissen. 2011. “Temperature-switchable Assembly of Supramolecular Virus-polymer Complexes.” Advanced Functional Materials 21 (11): 2012–2019.
APA
Kostiainen, M. A., Pietsch, C., Hoogenboom, R., Nolte, R. J., & Cornelissen, J. J. (2011). Temperature-switchable assembly of supramolecular virus-polymer complexes. ADVANCED FUNCTIONAL MATERIALS, 21(11), 2012–2019.
Vancouver
1.
Kostiainen MA, Pietsch C, Hoogenboom R, Nolte RJ, Cornelissen JJ. Temperature-switchable assembly of supramolecular virus-polymer complexes. ADVANCED FUNCTIONAL MATERIALS. 2011;21(11):2012–9.
MLA
Kostiainen, Mauri A, Christian Pietsch, Richard Hoogenboom, et al. “Temperature-switchable Assembly of Supramolecular Virus-polymer Complexes.” ADVANCED FUNCTIONAL MATERIALS 21.11 (2011): 2012–2019. Print.