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Poly(2-cyclopropyl-2-oxazoline): from rate acceleration by Cyclopropyl to Thermoresponsive properties

(2011) MACROMOLECULES. 44(11). p.4057-4064
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Abstract
The synthesis and microwave-assisted living cationic ring-opening polymerization of 2-cyclopropyl-2-oxazoline is reported revealing the fastest polymerization for an aliphatic substituted 2-oxazoline to date, which is ascribed to the electron withdrawing effect of the cyclopropyl group. The poly(2-cyclopropyl-2-oxazoline) (pCPropOx) represents an alternative thermo-responsive poly(2-oxazoline) with a reversible critical temperature close to body temperature. The cloud point (CP) of the obtained pCPropOx in aqueous solution was evaluated in detail by turbidimetry, dynamic light scattering (DLS) and viscosity measurements. pCPropOx is amorphous with a significantly higher glass transition temperature (T(g) similar to 80 degrees C) compared to the amorphous poly(2-n-propyl-2-oxazoline) (pnPropOx) (T(g) similar to 40 degrees C), while poly(2-isopropyl-2-oxazoline) piPropOx is semicrystalline. In addition, a pCPropOx comb polymer was prepared by methacrylic acid end-capping of the living cationic species followed by RAFT polymerization of the macromonomer. The polymer architecture does not influence the concentration dependence of the CP, however, both the CP and T(g) of the comb polymer are lower due to the increased number of hydrophobic end groups.
Keywords
N-ISOPROPYLACRYLAMIDE, CRITICAL SOLUTION TEMPERATURE, RESPONSIVE POLYMERS, AQUEOUS-SOLUTIONS, DRUG-DELIVERY, POLY(N-ISOPROPYLACRYLAMIDE), LCST, POLY(2-ALKYL-2-OXAZOLINE)S, POLY(2-ISOPROPYL-2-OXAZOLINE), POLY(2-OXAZOLINE)S

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Chicago
Bloksma, Meta M, Christine Weber, Igor Y Perevyazko, Anette Kuse, Anja Baumgartel, Antje Vollrath, Richard Hoogenboom, and Ulrich S Schubert. 2011. “Poly(2-cyclopropyl-2-oxazoline): From Rate Acceleration by Cyclopropyl to Thermoresponsive Properties.” Macromolecules 44 (11): 4057–4064.
APA
Bloksma, M. M., Weber, C., Perevyazko, I. Y., Kuse, A., Baumgartel, A., Vollrath, A., Hoogenboom, R., et al. (2011). Poly(2-cyclopropyl-2-oxazoline): from rate acceleration by Cyclopropyl to Thermoresponsive properties. MACROMOLECULES, 44(11), 4057–4064.
Vancouver
1.
Bloksma MM, Weber C, Perevyazko IY, Kuse A, Baumgartel A, Vollrath A, et al. Poly(2-cyclopropyl-2-oxazoline): from rate acceleration by Cyclopropyl to Thermoresponsive properties. MACROMOLECULES. 2011;44(11):4057–64.
MLA
Bloksma, Meta M et al. “Poly(2-cyclopropyl-2-oxazoline): From Rate Acceleration by Cyclopropyl to Thermoresponsive Properties.” MACROMOLECULES 44.11 (2011): 4057–4064. Print.
@article{1851500,
  abstract     = {The synthesis and microwave-assisted living cationic ring-opening polymerization of 2-cyclopropyl-2-oxazoline is reported revealing the fastest polymerization for an aliphatic substituted 2-oxazoline to date, which is ascribed to the electron withdrawing effect of the cyclopropyl group. The poly(2-cyclopropyl-2-oxazoline) (pCPropOx) represents an alternative thermo-responsive poly(2-oxazoline) with a reversible critical temperature close to body temperature. The cloud point (CP) of the obtained pCPropOx in aqueous solution was evaluated in detail by turbidimetry, dynamic light scattering (DLS) and viscosity measurements. pCPropOx is amorphous with a significantly higher glass transition temperature (T(g) similar to 80 degrees C) compared to the amorphous poly(2-n-propyl-2-oxazoline) (pnPropOx) (T(g) similar to 40 degrees C), while poly(2-isopropyl-2-oxazoline) piPropOx is semicrystalline. In addition, a pCPropOx comb polymer was prepared by methacrylic acid end-capping of the living cationic species followed by RAFT polymerization of the macromonomer. The polymer architecture does not influence the concentration dependence of the CP, however, both the CP and T(g) of the comb polymer are lower due to the increased number of hydrophobic end groups.},
  author       = {Bloksma, Meta M and Weber, Christine and Perevyazko, Igor Y and Kuse, Anette and Baumgartel, Anja and Vollrath, Antje and Hoogenboom, Richard and Schubert, Ulrich S},
  issn         = {0024-9297},
  journal      = {MACROMOLECULES},
  keywords     = {N-ISOPROPYLACRYLAMIDE,CRITICAL SOLUTION TEMPERATURE,RESPONSIVE POLYMERS,AQUEOUS-SOLUTIONS,DRUG-DELIVERY,POLY(N-ISOPROPYLACRYLAMIDE),LCST,POLY(2-ALKYL-2-OXAZOLINE)S,POLY(2-ISOPROPYL-2-OXAZOLINE),POLY(2-OXAZOLINE)S},
  language     = {eng},
  number       = {11},
  pages        = {4057--4064},
  title        = {Poly(2-cyclopropyl-2-oxazoline): from rate acceleration by Cyclopropyl to Thermoresponsive properties},
  url          = {http://dx.doi.org/10.1021/ma200514n},
  volume       = {44},
  year         = {2011},
}

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