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Correlations between white matter integrity and motor function in traumatic brain injury patients

Karen Caeyenberghs, Alexander Leemans, Monique Geurts, Catharine Vander Linden UGent, Bouwien CM Smits-Engelsman, Stefan Sunaert and Stephan P Swinnen (2011) NEUROREHABILITATION AND NEURAL REPAIR. 25(6). p.492-502
abstract
Background. Deterioration of motor function is one of several clinical manifestations following traumatic brain injury (TBI) in children and adolescents. Objective. To investigate the relationship between white matter (WM) integrity using diffusion tensor imaging (DTI) and motor functioning in young TBI patients. Methods. A group with moderate to severe TBI (n = 24) and a control group (n = 17) were scanned using DTI along with standard anatomical scans. Using ExploreDTI software, WM regions/tracts that carry efferent output (motor) from the brain were evaluated, as well as the corpus callosum, brainstem, internal capsule, and subcortical WM structures. Motor function was assessed using the Movement Assessment Battery for Children (M-ABC), consisting of manual dexterity, ball skills, and static and dynamic balance items. Results. TBI patients were less successful on the M-ABC than the controls and showed lower WM fractional anisotropy (FA) in the corpus callosum, anterior corona radiata, corticospinal tract, and cerebellum. Decreased FA was associated with lower motor performance in the TBI group but not in the control group. Conclusion. This study provides evidence for a structural alteration of motor pathways and regions in children and adolescents with TBI that are correlated with motor functioning. Further studies may be able to identify therapeutic targets and monitor the effects of new interventions.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
diffuse axonal injury, traumatic brain injury rehabilitation, MILD, CHILDREN, MUTUAL INFORMATION, CEREBELLAR ATROPHY, BEHAVIOR RELATIONSHIPS, TENSOR MRI, HEAD-INJURY, DIFFUSE AXONAL INJURY, MOVEMENT ASSESSMENT BATTERY, fractional anisotropy, motor skills, pediatric brain injury, CORPUS-CALLOSUM
journal title
NEUROREHABILITATION AND NEURAL REPAIR
Neurorehabil. Neural Repair
volume
25
issue
6
pages
492 - 502
Web of Science type
Article
Web of Science id
000291384200001
JCR category
REHABILITATION
JCR impact factor
4.495 (2011)
JCR rank
1/57 (2011)
JCR quartile
1 (2011)
ISSN
1545-9683
DOI
10.1177/1545968310394870
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1851451
handle
http://hdl.handle.net/1854/LU-1851451
date created
2011-07-01 15:59:55
date last changed
2016-12-19 15:42:31
@article{1851451,
  abstract     = {Background. Deterioration of motor function is one of several clinical manifestations following traumatic brain injury (TBI) in children and adolescents. Objective. To investigate the relationship between white matter (WM) integrity using diffusion tensor imaging (DTI) and motor functioning in young TBI patients. Methods. A group with moderate to severe TBI (n = 24) and a control group (n = 17) were scanned using DTI along with standard anatomical scans. Using ExploreDTI software, WM regions/tracts that carry efferent output (motor) from the brain were evaluated, as well as the corpus callosum, brainstem, internal capsule, and subcortical WM structures. Motor function was assessed using the Movement Assessment Battery for Children (M-ABC), consisting of manual dexterity, ball skills, and static and dynamic balance items. Results. TBI patients were less successful on the M-ABC than the controls and showed lower WM fractional anisotropy (FA) in the corpus callosum, anterior corona radiata, corticospinal tract, and cerebellum. Decreased FA was associated with lower motor performance in the TBI group but not in the control group. Conclusion. This study provides evidence for a structural alteration of motor pathways and regions in children and adolescents with TBI that are correlated with motor functioning. Further studies may be able to identify therapeutic targets and monitor the effects of new interventions.},
  author       = {Caeyenberghs, Karen and Leemans, Alexander and Geurts, Monique and Vander Linden, Catharine and Smits-Engelsman, Bouwien CM and Sunaert, Stefan and Swinnen, Stephan P},
  issn         = {1545-9683},
  journal      = {NEUROREHABILITATION AND NEURAL REPAIR},
  keyword      = {diffuse axonal injury,traumatic brain injury rehabilitation,MILD,CHILDREN,MUTUAL INFORMATION,CEREBELLAR ATROPHY,BEHAVIOR RELATIONSHIPS,TENSOR MRI,HEAD-INJURY,DIFFUSE AXONAL INJURY,MOVEMENT ASSESSMENT BATTERY,fractional anisotropy,motor skills,pediatric brain injury,CORPUS-CALLOSUM},
  language     = {eng},
  number       = {6},
  pages        = {492--502},
  title        = {Correlations between white matter integrity and motor function in traumatic brain injury patients},
  url          = {http://dx.doi.org/10.1177/1545968310394870},
  volume       = {25},
  year         = {2011},
}

Chicago
Caeyenberghs, Karen, Alexander Leemans, Monique Geurts, CATHARINE VANDER LINDEN, Bouwien CM Smits-Engelsman, Stefan Sunaert, and Stephan P Swinnen. 2011. “Correlations Between White Matter Integrity and Motor Function in Traumatic Brain Injury Patients.” Neurorehabilitation and Neural Repair 25 (6): 492–502.
APA
Caeyenberghs, Karen, Leemans, A., Geurts, M., VANDER LINDEN, C., Smits-Engelsman, B. C., Sunaert, S., & Swinnen, S. P. (2011). Correlations between white matter integrity and motor function in traumatic brain injury patients. NEUROREHABILITATION AND NEURAL REPAIR, 25(6), 492–502.
Vancouver
1.
Caeyenberghs K, Leemans A, Geurts M, VANDER LINDEN C, Smits-Engelsman BC, Sunaert S, et al. Correlations between white matter integrity and motor function in traumatic brain injury patients. NEUROREHABILITATION AND NEURAL REPAIR. 2011;25(6):492–502.
MLA
Caeyenberghs, Karen, Alexander Leemans, Monique Geurts, et al. “Correlations Between White Matter Integrity and Motor Function in Traumatic Brain Injury Patients.” NEUROREHABILITATION AND NEURAL REPAIR 25.6 (2011): 492–502. Print.