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Alternatively spliced NKp30 isoforms affect the prognosis of gastrointestinal stromal tumors

Nicolas F Delahaye, Sylvie Rusakiewicz, Isabelle Martins, Cedric Menard, Stephan Roux, Luc Lyonnet, Pascale Paul, Matthieu Sarabi, Nathalie Chaput and Michaela Semeraro, et al. (2011) NATURE MEDICINE. 17(6). p.700-U91
abstract
The natural killer (NK) cell receptor NKp30 is involved in the recognition of tumor and dendritic cells (DCs). Here we describe the influence of three NKp30 splice variants on the prognosis of gastrointestinal sarcoma (GIST), a malignancy that expresses NKp30 ligands and that is treated with NK-stimulatory KIT tyrosine kinase inhibitors. Healthy individuals and those with GIST show distinct patterns of transcription of functionally different NKp30 isoforms. In a retrospective analysis of 80 individuals with GIST, predominant expression of the immunosuppressive NKp30c isoform (over the immunostimulatory NKp30a and NKp30b isoforms) was associated with reduced survival of subjects, decreased NKp30-dependent tumor necrosis factor-alpha (TNF-alpha) and CD107a release, and defective interferon-gamma (IFN-gamma) and interleukin-12 (IL-12) secretion in the NK-DC cross-talk that could be restored by blocking of IL-10. Preferential NKp30c expression resulted partly from a single-nucleotide polymorphism at position 3790 in the 3' untranslated region of the gene encoding NKp30. The genetically determined NKp30 status predicts the clinical outcomes of individuals with GIST independently from KIT mutation.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
EXPRESSION, CLASS-III, IL-10 PRODUCTION, TRIGGERING RECEPTOR, HUMAN MHC, CYTOTOXICITY RECEPTORS, NK CELLS, HUMAN DENDRITIC CELLS, NATURAL-KILLER-CELLS, C-KIT
journal title
NATURE MEDICINE
Nat. Med.
volume
17
issue
6
pages
700 - U91
Web of Science type
Article
Web of Science id
000291308800030
JCR category
MEDICINE, RESEARCH & EXPERIMENTAL
JCR impact factor
22.462 (2011)
JCR rank
1/109 (2011)
JCR quartile
1 (2011)
ISSN
1078-8956
DOI
10.1038/nm.2366
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1851330
handle
http://hdl.handle.net/1854/LU-1851330
date created
2011-07-01 15:42:43
date last changed
2013-01-30 09:41:07
@article{1851330,
  abstract     = {The natural killer (NK) cell receptor NKp30 is involved in the recognition of tumor and dendritic cells (DCs). Here we describe the influence of three NKp30 splice variants on the prognosis of gastrointestinal sarcoma (GIST), a malignancy that expresses NKp30 ligands and that is treated with NK-stimulatory KIT tyrosine kinase inhibitors. Healthy individuals and those with GIST show distinct patterns of transcription of functionally different NKp30 isoforms. In a retrospective analysis of 80 individuals with GIST, predominant expression of the immunosuppressive NKp30c isoform (over the immunostimulatory NKp30a and NKp30b isoforms) was associated with reduced survival of subjects, decreased NKp30-dependent tumor necrosis factor-alpha (TNF-alpha) and CD107a release, and defective interferon-gamma (IFN-gamma) and interleukin-12 (IL-12) secretion in the NK-DC cross-talk that could be restored by blocking of IL-10. Preferential NKp30c expression resulted partly from a single-nucleotide polymorphism at position 3790 in the 3' untranslated region of the gene encoding NKp30. The genetically determined NKp30 status predicts the clinical outcomes of individuals with GIST independently from KIT mutation.},
  author       = {Delahaye, Nicolas F and Rusakiewicz, Sylvie and Martins, Isabelle and Menard, Cedric and Roux, Stephan and Lyonnet, Luc and Paul, Pascale and Sarabi, Matthieu and Chaput, Nathalie and Semeraro, Michaela and Minard-Colin, Veronique and Poirier-Colame, Vichnou and Chaba, Kariman and Flament, Caroline and Baud, Veronique and Authier, Helene and Kerdine-Romer, Saadia and Pallardy, Marc and Cremer, Isabelle and Peaudecerf, Laetitia and Rocha, Benedita and Valteau-Couanet, Dominique and Gutierrez, Javier Celis and Nunes, Jacques A and Commo, Frederic and Bonvalot, Sylvie and Ibrahim, Nicolas and Terrier, Philippe and Opolon, Paule and Bottino, Cristina and Moretta, Alessandro and Tavernier, Jan and Rihet, Pascal and Coindre, Jean-Michel and Blay, Jean-Yves and Isambert, Nicolas and Emile, Jean-Francois and Vivier, Eric and Lecesne, Axel and Kroemer, Guido and Zitvogel, Laurence},
  issn         = {1078-8956},
  journal      = {NATURE MEDICINE},
  keyword      = {EXPRESSION,CLASS-III,IL-10 PRODUCTION,TRIGGERING RECEPTOR,HUMAN MHC,CYTOTOXICITY RECEPTORS,NK CELLS,HUMAN DENDRITIC CELLS,NATURAL-KILLER-CELLS,C-KIT},
  language     = {eng},
  number       = {6},
  pages        = {700--U91},
  title        = {Alternatively spliced NKp30 isoforms affect the prognosis of gastrointestinal stromal tumors},
  url          = {http://dx.doi.org/10.1038/nm.2366},
  volume       = {17},
  year         = {2011},
}

Chicago
Delahaye, Nicolas F, Sylvie Rusakiewicz, Isabelle Martins, Cedric Menard, Stephan Roux, Luc Lyonnet, Pascale Paul, et al. 2011. “Alternatively Spliced NKp30 Isoforms Affect the Prognosis of Gastrointestinal Stromal Tumors.” Nature Medicine 17 (6): 700–U91.
APA
Delahaye, N. F., Rusakiewicz, S., Martins, I., Menard, C., Roux, S., Lyonnet, L., Paul, P., et al. (2011). Alternatively spliced NKp30 isoforms affect the prognosis of gastrointestinal stromal tumors. NATURE MEDICINE, 17(6), 700–U91.
Vancouver
1.
Delahaye NF, Rusakiewicz S, Martins I, Menard C, Roux S, Lyonnet L, et al. Alternatively spliced NKp30 isoforms affect the prognosis of gastrointestinal stromal tumors. NATURE MEDICINE. 2011;17(6):700–U91.
MLA
Delahaye, Nicolas F, Sylvie Rusakiewicz, Isabelle Martins, et al. “Alternatively Spliced NKp30 Isoforms Affect the Prognosis of Gastrointestinal Stromal Tumors.” NATURE MEDICINE 17.6 (2011): 700–U91. Print.