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Speciation of six arsenic compounds using high-performance liquid chromatography inductively coupled plasma mass spectrometry with sample introduction by thermospray nebulization

Steven Saverwyns, Xinrong Zhang, Frank Vanhaecke UGent, Rita Cornelis UGent, Luc Moens UGent and Richard Dams UGent (1997) JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY. 12(9). p.1047-1052
abstract
A hyphenated technique for the determination of As-III, As-V, arsenobetaine (AsB), arsenocholine (AsC), monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA) has been developed by coupling an anion-exchange column to an inductively coupled plasma mass spectrometer, using an in-house developed thermospray nebulizer (TN) as an interface, Optimisation of the chromatographic conditions led to baseline separation of the signals from the six aforementioned compounds in approximately 10 min, using isocratic elution, Application of the TN offered a ten-fold improvement in sensitivity in comparison with the standard pneumatic nebulizer, To prevent clogging of the torch and to slow down deposit formation on the sampling cone,;use was made of a second HPLC pump and a switching valve, allowing rinsing with HNO3 between two measurements, Detection limits were also improved and were in the range 0.04-0.12 mu g l(-1) as arsenic, Finally, the technique developed was used for the analysis of several mineral waters and urine samples, The improved sensitivity was also obtained for real samples, In the mineral waters analysed only As-V could be detected, In the ten-fold diluted urine samples, all aforementioned arsenic compounds were present, except for AsC, which could not be detected.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (proceedingsPaper)
publication status
published
subject
keyword
inductively coupled plasma mass spectrometry, arsenic speciation, thermospray nebulization, anion-exchange liquid chromatography, urine, mineral waters, ATOMIC EMISSION-SPECTROMETRY, HIGH-PRESSURE NEBULIZATION, ONLINE UV PHOTOOXIDATION, ABSORPTION SPECTROMETRY, ELEMENTAL SPECIATION, ION CHROMATOGRAPHY, FLOW-INJECTION, GENERATION, INTERFERENCES, OPTIMIZATION
journal title
JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
J. Anal. At. Spectrom.
volume
12
issue
9
pages
1047 - 1052
conference name
1997 European winter conference on Plasma Spectrochemistry
conference location
Ghent, Belgium
conference start
1997-01-12
conference end
1997-01-17
Web of Science type
Article
ISSN
0267-9477
DOI
10.1039/a701554b
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
185032
handle
http://hdl.handle.net/1854/LU-185032
date created
2004-01-14 13:41:00
date last changed
2012-11-21 13:14:43
@article{185032,
  abstract     = {A hyphenated technique for the determination of As-III, As-V, arsenobetaine (AsB), arsenocholine (AsC), monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA) has been developed by coupling an anion-exchange column to an inductively coupled plasma mass spectrometer, using an in-house developed thermospray nebulizer (TN) as an interface, Optimisation of the chromatographic conditions led to baseline separation of the signals from the six aforementioned compounds in approximately 10 min, using isocratic elution, Application of the TN offered a ten-fold improvement in sensitivity in comparison with the standard pneumatic nebulizer, To prevent clogging of the torch and to slow down deposit formation on the sampling cone,;use was made of a second HPLC pump and a switching valve, allowing rinsing with HNO3 between two measurements, Detection limits were also improved and were in the range 0.04-0.12 mu g l(-1) as arsenic, Finally, the technique developed was used for the analysis of several mineral waters and urine samples, The improved sensitivity was also obtained for real samples, In the mineral waters analysed only As-V could be detected, In the ten-fold diluted urine samples, all aforementioned arsenic compounds were present, except for AsC, which could not be detected.},
  author       = {Saverwyns, Steven and Zhang, Xinrong and Vanhaecke, Frank and Cornelis, Rita and Moens, Luc and Dams, Richard},
  issn         = {0267-9477},
  journal      = {JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY},
  keyword      = {inductively coupled plasma mass spectrometry,arsenic speciation,thermospray nebulization,anion-exchange liquid chromatography,urine,mineral waters,ATOMIC EMISSION-SPECTROMETRY,HIGH-PRESSURE NEBULIZATION,ONLINE UV PHOTOOXIDATION,ABSORPTION SPECTROMETRY,ELEMENTAL SPECIATION,ION CHROMATOGRAPHY,FLOW-INJECTION,GENERATION,INTERFERENCES,OPTIMIZATION},
  language     = {eng},
  location     = {Ghent, Belgium},
  number       = {9},
  pages        = {1047--1052},
  title        = {Speciation of six arsenic compounds using high-performance liquid chromatography inductively coupled plasma mass spectrometry with sample introduction by thermospray nebulization},
  url          = {http://dx.doi.org/10.1039/a701554b},
  volume       = {12},
  year         = {1997},
}

Chicago
Saverwyns, Steven, Xinrong Zhang, Frank Vanhaecke, Rita Cornelis, Luc Moens, and Richard Dams. 1997. “Speciation of Six Arsenic Compounds Using High-performance Liquid Chromatography Inductively Coupled Plasma Mass Spectrometry with Sample Introduction by Thermospray Nebulization.” Journal of Analytical Atomic Spectrometry 12 (9): 1047–1052.
APA
Saverwyns, S., Zhang, X., Vanhaecke, F., Cornelis, R., Moens, L., & Dams, R. (1997). Speciation of six arsenic compounds using high-performance liquid chromatography inductively coupled plasma mass spectrometry with sample introduction by thermospray nebulization. JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY, 12(9), 1047–1052. Presented at the 1997 European winter conference on Plasma Spectrochemistry.
Vancouver
1.
Saverwyns S, Zhang X, Vanhaecke F, Cornelis R, Moens L, Dams R. Speciation of six arsenic compounds using high-performance liquid chromatography inductively coupled plasma mass spectrometry with sample introduction by thermospray nebulization. JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY. 1997;12(9):1047–52.
MLA
Saverwyns, Steven, Xinrong Zhang, Frank Vanhaecke, et al. “Speciation of Six Arsenic Compounds Using High-performance Liquid Chromatography Inductively Coupled Plasma Mass Spectrometry with Sample Introduction by Thermospray Nebulization.” JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY 12.9 (1997): 1047–1052. Print.