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Sizing nanomatter in biological fluids by fluorescence single particle tracking

Kevin Braeckmans UGent, Kevin Buyens UGent, Wim Bouquet-Geerardyn UGent, Chris Vervaet UGent, Philippe Joye UGent, Filip De Vos UGent, Laurent Plawinski, Loic Doeuvre, Eduardo Angles-Cano and Niek Sanders UGent, et al. (2010) NANO LETTERS. 10(11). p.4435-4442
abstract
Accurate sizing of nanoparticles in biological media is important for drug delivery and biomedical imaging applications since size directly influences the nanoparticle processing and nanotoxicity in vivo. Using fluorescence single particle cracking we have succeeded for the first time in following the aggregation of drug delivery nanoparticles in real time in undiluted whole blood. We demonstrate that, by using a suitable surface functionalization, nanoparticle aggregation in the blood circulation is prevented to a large extent.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
MICROPARTICLES, DYNAMICS, LIPOSOMES, DELIVERY, POLY(ETHYLENE GLYCOL), CELLS, DRUG, SIZE, Nanobiophotonics, nanoparticles, drug delivery, nanomedicines, medical diagnostics
journal title
NANO LETTERS
Nano Lett.
volume
10
issue
11
pages
4435 - 4442
Web of Science type
Article
Web of Science id
000283907600024
JCR category
MATERIALS SCIENCE, MULTIDISCIPLINARY
JCR impact factor
12.186 (2010)
JCR rank
5/219 (2010)
JCR quartile
1 (2010)
ISSN
1530-6984
DOI
10.1021/nl103264u
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1850220
handle
http://hdl.handle.net/1854/LU-1850220
date created
2011-06-30 16:56:27
date last changed
2011-07-05 13:21:55
@article{1850220,
  abstract     = {Accurate sizing of nanoparticles in biological media is important for drug delivery and biomedical imaging applications since size directly influences the nanoparticle processing and nanotoxicity in vivo. Using fluorescence single particle cracking we have succeeded for the first time in following the aggregation of drug delivery nanoparticles in real time in undiluted whole blood. We demonstrate that, by using a suitable surface functionalization, nanoparticle aggregation in the blood circulation is prevented to a large extent.},
  author       = {Braeckmans, Kevin and Buyens, Kevin and Bouquet-Geerardyn, Wim and Vervaet, Chris and Joye, Philippe and De Vos, Filip and Plawinski, Laurent and Doeuvre, Loic and Angles-Cano, Eduardo and Sanders, Niek and Demeester, Jo and De Smedt, Stefaan},
  issn         = {1530-6984},
  journal      = {NANO LETTERS},
  keyword      = {MICROPARTICLES,DYNAMICS,LIPOSOMES,DELIVERY,POLY(ETHYLENE GLYCOL),CELLS,DRUG,SIZE,Nanobiophotonics,nanoparticles,drug delivery,nanomedicines,medical diagnostics},
  language     = {eng},
  number       = {11},
  pages        = {4435--4442},
  title        = {Sizing nanomatter in biological fluids by fluorescence single particle tracking},
  url          = {http://dx.doi.org/10.1021/nl103264u},
  volume       = {10},
  year         = {2010},
}

Chicago
Braeckmans, Kevin, Kevin Buyens, Wim Bouquet-Geerardyn, Chris Vervaet, Philippe Joye, Filip De Vos, Laurent Plawinski, et al. 2010. “Sizing Nanomatter in Biological Fluids by Fluorescence Single Particle Tracking.” Nano Letters 10 (11): 4435–4442.
APA
Braeckmans, K., Buyens, K., Bouquet-Geerardyn, W., Vervaet, C., Joye, P., De Vos, F., Plawinski, L., et al. (2010). Sizing nanomatter in biological fluids by fluorescence single particle tracking. NANO LETTERS, 10(11), 4435–4442.
Vancouver
1.
Braeckmans K, Buyens K, Bouquet-Geerardyn W, Vervaet C, Joye P, De Vos F, et al. Sizing nanomatter in biological fluids by fluorescence single particle tracking. NANO LETTERS. 2010;10(11):4435–42.
MLA
Braeckmans, Kevin, Kevin Buyens, Wim Bouquet-Geerardyn, et al. “Sizing Nanomatter in Biological Fluids by Fluorescence Single Particle Tracking.” NANO LETTERS 10.11 (2010): 4435–4442. Print.