Sizing nanomatter in biological fluids by fluorescence single particle tracking
- Author
- Kevin Braeckmans (UGent) , Kevin Buyens (UGent) , Wim Bouquet-Geerardyn, Chris Vervaet (UGent) , Philippe Joye (UGent) , Filip De Vos (UGent) , Laurent Plawinski, Loic Doeuvre, Eduardo Angles-Cano, Niek Sanders (UGent) , Jo Demeester (UGent) and Stefaan De Smedt (UGent)
- Organization
- Abstract
- Accurate sizing of nanoparticles in biological media is important for drug delivery and biomedical imaging applications since size directly influences the nanoparticle processing and nanotoxicity in vivo. Using fluorescence single particle cracking we have succeeded for the first time in following the aggregation of drug delivery nanoparticles in real time in undiluted whole blood. We demonstrate that, by using a suitable surface functionalization, nanoparticle aggregation in the blood circulation is prevented to a large extent.
- Keywords
- MICROPARTICLES, DYNAMICS, LIPOSOMES, DELIVERY, POLY(ETHYLENE GLYCOL), CELLS, DRUG, SIZE, Nanobiophotonics, nanoparticles, drug delivery, nanomedicines, medical diagnostics
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-1850220
- MLA
- Braeckmans, Kevin et al. “Sizing Nanomatter in Biological Fluids by Fluorescence Single Particle Tracking.” NANO LETTERS 10.11 (2010): 4435–4442. Print.
- APA
- Braeckmans, K., Buyens, K., Bouquet-Geerardyn, W., Vervaet, C., Joye, P., De Vos, F., Plawinski, L., et al. (2010). Sizing nanomatter in biological fluids by fluorescence single particle tracking. NANO LETTERS, 10(11), 4435–4442.
- Chicago author-date
- Braeckmans, Kevin, Kevin Buyens, Wim Bouquet-Geerardyn, Chris Vervaet, Philippe Joye, Filip De Vos, Laurent Plawinski, et al. 2010. “Sizing Nanomatter in Biological Fluids by Fluorescence Single Particle Tracking.” Nano Letters 10 (11): 4435–4442.
- Chicago author-date (all authors)
- Braeckmans, Kevin, Kevin Buyens, Wim Bouquet-Geerardyn, Chris Vervaet, Philippe Joye, Filip De Vos, Laurent Plawinski, Loic Doeuvre, Eduardo Angles-Cano, Niek Sanders, Jo Demeester, and Stefaan De Smedt. 2010. “Sizing Nanomatter in Biological Fluids by Fluorescence Single Particle Tracking.” Nano Letters 10 (11): 4435–4442.
- Vancouver
- 1.Braeckmans K, Buyens K, Bouquet-Geerardyn W, Vervaet C, Joye P, De Vos F, et al. Sizing nanomatter in biological fluids by fluorescence single particle tracking. NANO LETTERS. 2010;10(11):4435–42.
- IEEE
- [1]K. Braeckmans et al., “Sizing nanomatter in biological fluids by fluorescence single particle tracking,” NANO LETTERS, vol. 10, no. 11, pp. 4435–4442, 2010.
@article{1850220,
abstract = {{Accurate sizing of nanoparticles in biological media is important for drug delivery and biomedical imaging applications since size directly influences the nanoparticle processing and nanotoxicity in vivo. Using fluorescence single particle cracking we have succeeded for the first time in following the aggregation of drug delivery nanoparticles in real time in undiluted whole blood. We demonstrate that, by using a suitable surface functionalization, nanoparticle aggregation in the blood circulation is prevented to a large extent.}},
author = {{Braeckmans, Kevin and Buyens, Kevin and Bouquet-Geerardyn, Wim and Vervaet, Chris and Joye, Philippe and De Vos, Filip and Plawinski, Laurent and Doeuvre, Loic and Angles-Cano, Eduardo and Sanders, Niek and Demeester, Jo and De Smedt, Stefaan}},
issn = {{1530-6984}},
journal = {{NANO LETTERS}},
keywords = {{MICROPARTICLES,DYNAMICS,LIPOSOMES,DELIVERY,POLY(ETHYLENE GLYCOL),CELLS,DRUG,SIZE,Nanobiophotonics,nanoparticles,drug delivery,nanomedicines,medical diagnostics}},
language = {{eng}},
number = {{11}},
pages = {{4435--4442}},
title = {{Sizing nanomatter in biological fluids by fluorescence single particle tracking}},
url = {{http://dx.doi.org/10.1021/nl103264u}},
volume = {{10}},
year = {{2010}},
}
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