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Sexual dimorphism in the early life programming of serum leptin levels in European adolescents: the HELENA study

Idoia Labayen, Jonatan R Ruiz, Inge Huybrechts UGent, Francisco B Ortega, Gerardo Rodríguez, Stefaan De Henauw UGent, Christina Breidenassel, David Jiménez-Pavón, Krishna Vyncke, Laura Censi, et al. (2011) JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 96(8). p.E1330-E1334
abstract
Aim: The aim of this study was to test the hypothesis that a lower birth weight, as an indicator of adverse intrauterine environment, is associated with higher serum leptin levels in European adolescents. We also examined the possible sexual dimorphism in this relationship. Methods: Fasting serum leptin was measured in 757 European born at term adolescents (429 females) aged 14.6 +/- 1.2 yr. We measured weight and height, and body mass index was calculated. Birth weight, duration of pregnancy, and duration of breast-feeding were obtained from parental records. Duration of pregnancy and breast-feeding, pubertal status, center, body mass index, and physical activity were entered as confounders in the analyses. Results: There was a significant interaction effect between sex and birth weight on serum leptin levels (P = 0.044). We observed that body weight at birth was negatively and significantly associated with serum leptin levels only in female adolescents (beta = -0.109; adjusted P = 0.008). The association persisted after further controlling for physical activity (beta = -0.115; adjusted P = 0.016). Conclusions: These findings provide further evidence for a sex-specific programming effect of birth weight on serum leptin levels. Our results also contribute to explain the detrimental health effects associated with lower birth weight, such as long-term increased risk of developing obesity and type 2 diabetes.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
SPANISH ADOLESCENTS, BIRTH-WEIGHT, PHYSICAL-ACTIVITY, BODY-COMPOSITION, FAT DISTRIBUTION, OBESITY, NUTRITION, ORIGINS, UNDERNUTRITION, METABOLISM
journal title
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
J. Clin. Endocrinol. Metab.
volume
96
issue
8
pages
E1330 - E1334
Web of Science type
Article
Web of Science id
000293516400020
JCR category
ENDOCRINOLOGY & METABOLISM
JCR impact factor
5.967 (2011)
JCR rank
15/121 (2011)
JCR quartile
1 (2011)
ISSN
0021-972X
DOI
10.1210/jc.2011-1036
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1848070
handle
http://hdl.handle.net/1854/LU-1848070
date created
2011-06-30 00:50:07
date last changed
2016-12-19 15:39:12
@article{1848070,
  abstract     = {Aim: The aim of this study was to test the hypothesis that a lower birth weight, as an indicator of adverse intrauterine environment, is associated with higher serum leptin levels in European adolescents. We also examined the possible sexual dimorphism in this relationship. 
Methods: Fasting serum leptin was measured in 757 European born at term adolescents (429 females) aged 14.6 +/- 1.2 yr. We measured weight and height, and body mass index was calculated. Birth weight, duration of pregnancy, and duration of breast-feeding were obtained from parental records. Duration of pregnancy and breast-feeding, pubertal status, center, body mass index, and physical activity were entered as confounders in the analyses. 
Results: There was a significant interaction effect between sex and birth weight on serum leptin levels (P = 0.044). We observed that body weight at birth was negatively and significantly associated with serum leptin levels only in female adolescents (beta = -0.109; adjusted P = 0.008). The association persisted after further controlling for physical activity (beta = -0.115; adjusted P = 0.016). 
Conclusions: These findings provide further evidence for a sex-specific programming effect of birth weight on serum leptin levels. Our results also contribute to explain the detrimental health effects associated with lower birth weight, such as long-term increased risk of developing obesity and type 2 diabetes.},
  author       = {Labayen, Idoia and Ruiz, Jonatan R and Huybrechts, Inge and Ortega, Francisco B and Rodr{\'i}guez, Gerardo and De Henauw, Stefaan and Breidenassel, Christina and Jim{\'e}nez-Pav{\'o}n, David and Vyncke, Krishna and Censi, Laura and Molnar, D{\'e}n{\'e}s and Widhalm, Kurt and Kafatos, Anthony and Plada, Mar{\'i}a and D{\'i}az, Ligia E and Marcos, Ascensi{\'o}n and Moreno, Luis A and Gottrand, Fr{\'e}d{\'e}ric},
  issn         = {0021-972X},
  journal      = {JOURNAL OF CLINICAL ENDOCRINOLOGY \& METABOLISM},
  keyword      = {SPANISH ADOLESCENTS,BIRTH-WEIGHT,PHYSICAL-ACTIVITY,BODY-COMPOSITION,FAT DISTRIBUTION,OBESITY,NUTRITION,ORIGINS,UNDERNUTRITION,METABOLISM},
  language     = {eng},
  number       = {8},
  pages        = {E1330--E1334},
  title        = {Sexual dimorphism in the early life programming of serum leptin levels in European adolescents: the HELENA study},
  url          = {http://dx.doi.org/10.1210/jc.2011-1036},
  volume       = {96},
  year         = {2011},
}

Chicago
Labayen, Idoia, Jonatan R Ruiz, Inge Huybrechts, Francisco B Ortega, Gerardo Rodríguez, Stefaan De Henauw, Christina Breidenassel, et al. 2011. “Sexual Dimorphism in the Early Life Programming of Serum Leptin Levels in European Adolescents: The HELENA Study.” Journal of Clinical Endocrinology & Metabolism 96 (8): E1330–E1334.
APA
Labayen, Idoia, Ruiz, J. R., Huybrechts, I., Ortega, F. B., Rodríguez, G., De Henauw, S., Breidenassel, C., et al. (2011). Sexual dimorphism in the early life programming of serum leptin levels in European adolescents: the HELENA study. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 96(8), E1330–E1334.
Vancouver
1.
Labayen I, Ruiz JR, Huybrechts I, Ortega FB, Rodríguez G, De Henauw S, et al. Sexual dimorphism in the early life programming of serum leptin levels in European adolescents: the HELENA study. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2011;96(8):E1330–E1334.
MLA
Labayen, Idoia, Jonatan R Ruiz, Inge Huybrechts, et al. “Sexual Dimorphism in the Early Life Programming of Serum Leptin Levels in European Adolescents: The HELENA Study.” JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 96.8 (2011): E1330–E1334. Print.