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The prevalence of human papillomavirus infection in Mombasa, Kenya

(2010) CANCER CAUSES & CONTROL. 21(12). p.2309-2313
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Abstract
Objectives A human papillomavirus (HPV) prevalence survey was done in Mombasa, Kenya, to improve the knowledge of HPV prevalence and genotype distribution in sub-Saharan African countries overall, and in women of different ages. Methods HPV prevalence was assessed using PCR in women older than 15 years attending family planning and mother-child care services. Results Among 496 women, HPV prevalence was high (42.3%; 95% CI: 37.9-46.8; world age-standardized). Moreover, 46% of HPV-positive women harbored multiple-type infections. The most common types were HPV58 (10.5% of women), HPV16 (7.7%), HPV53 (6.7%), HPV18 (4.6%), and HPV6 (4.4%), and the prevalence of any high-risk HPV type was 28.8%. HPV prevalence was elevated among all age-groups (range 36.4-45.7%). Independent associations with HPV positivity were found for being in a polygamous marriage (OR = 1.7) and lifetime number of sexual partners (OR for >= 3 vs. 1 = 1.5), although they were of only borderline statistical significance. Conclusions These findings differ from other world regions, showing a high HPV burden in all age-groups with a high proportion of multiple-type infections. Our data strengthen the urgency of HPV vaccination in Kenya but also highlight the elevated number of women who would have positive results in an HPV-based screening program in the country.
Keywords
Africa, Kenya, SQUAMOUS INTRAEPITHELIAL LESIONS, CERVICAL-CANCER, GENOTYPE DISTRIBUTION, WOMEN, HIV, POPULATION, DNA, EPIDEMIOLOGY, METAANALYSIS, WORLDWIDE, Cervical cancer, Human papillomavirus prevalence

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Chicago
De Vuyst, Hugo, Maria Rita Parisi, Andrew Karani, Kishor Mandaliya, Lucy Muchiri, Salvatore Vaccarella, Marleen Temmerman, Silvia Franceschi, and Flavia Lillo. 2010. “The Prevalence of Human Papillomavirus Infection in Mombasa, Kenya.” Cancer Causes & Control 21 (12): 2309–2313.
APA
De Vuyst, H., Parisi, M. R., Karani, A., Mandaliya, K., Muchiri, L., Vaccarella, S., Temmerman, M., et al. (2010). The prevalence of human papillomavirus infection in Mombasa, Kenya. CANCER CAUSES & CONTROL, 21(12), 2309–2313.
Vancouver
1.
De Vuyst H, Parisi MR, Karani A, Mandaliya K, Muchiri L, Vaccarella S, et al. The prevalence of human papillomavirus infection in Mombasa, Kenya. CANCER CAUSES & CONTROL. 2010;21(12):2309–13.
MLA
De Vuyst, Hugo, Maria Rita Parisi, Andrew Karani, et al. “The Prevalence of Human Papillomavirus Infection in Mombasa, Kenya.” CANCER CAUSES & CONTROL 21.12 (2010): 2309–2313. Print.
@article{1844535,
  abstract     = {Objectives A human papillomavirus (HPV) prevalence survey was done in Mombasa, Kenya, to improve the knowledge of HPV prevalence and genotype distribution in sub-Saharan African countries overall, and in women of different ages.
Methods HPV prevalence was assessed using PCR in women older than 15 years attending family planning and mother-child care services.
Results Among 496 women, HPV prevalence was high (42.3\%; 95\% CI: 37.9-46.8; world age-standardized). Moreover, 46\% of HPV-positive women harbored multiple-type infections. The most common types were HPV58 (10.5\% of women), HPV16 (7.7\%), HPV53 (6.7\%), HPV18 (4.6\%), and HPV6 (4.4\%), and the prevalence of any high-risk HPV type was 28.8\%. HPV prevalence was elevated among all age-groups (range 36.4-45.7\%). Independent associations with HPV positivity were found for being in a polygamous marriage (OR = 1.7) and lifetime number of sexual partners (OR for {\textrangle}= 3 vs. 1 = 1.5), although they were of only borderline statistical significance.
Conclusions These findings differ from other world regions, showing a high HPV burden in all age-groups with a high proportion of multiple-type infections. Our data strengthen the urgency of HPV vaccination in Kenya but also highlight the elevated number of women who would have positive results in an HPV-based screening program in the country.},
  author       = {De Vuyst, Hugo and Parisi, Maria Rita and Karani, Andrew and Mandaliya, Kishor and Muchiri, Lucy and Vaccarella, Salvatore and Temmerman, Marleen and Franceschi, Silvia and Lillo, Flavia},
  issn         = {0957-5243},
  journal      = {CANCER CAUSES \& CONTROL},
  language     = {eng},
  number       = {12},
  pages        = {2309--2313},
  title        = {The prevalence of human papillomavirus infection in Mombasa, Kenya},
  url          = {http://dx.doi.org/10.1007/s10552-010-9645-z},
  volume       = {21},
  year         = {2010},
}

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