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Bacterial vaginosis is associated with uterine cervical human papillomavirus infection: a meta-analysis

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Abstract
Background: Bacterial vaginosis (BV), an alteration of vaginal flora involving a decrease in Lactobacilli and predominance of anaerobic bacteria, is among the most common cause of vaginal complaints for women of childbearing age. It is well known that BV has an influence in acquisition of certain genital infections. However, association between BV and cervical human papillomavirus (HPV) infection has been inconsistent among studies. The objective of this meta- analysis of published studies is to clarify and summarize published literature on the extent to which BV is associated with cervical HPV infection. Methods: Medline and Web of Science were systematically searched for eligible publications until December 2009. Articles were selected based on inclusion and exclusion criteria. After testing heterogeneity of studies, meta-analysis was performed using random effect model. Results: Twelve eligible studies were selected to review the association between BV and HPV, including a total of 6,372 women. The pooled prevalence of BV was 32%. The overall estimated odds ratio (OR) showed a positive association between BV and cervical HPV infection (OR, 1.43; 95% confidence interval, 1.11-1.84). Conclusion: This meta- analysis of available literature resulted in a positive association between BV and uterine cervical HPV infection.
Keywords
RISK-FACTORS, NATURAL-HISTORY, CLUE CELLS, WOMEN, SMEARS, DYSBACTERIOSIS, EPIDEMIOLOGY, INTRAEPITHELIAL NEOPLASIA, SIMPLEX-VIRUS TYPE-2, CHLAMYDIA-TRACHOMATIS

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Chicago
Gillet, Evy, Joris Meys, Hans Verstraelen, Carolyne Bosire, Philippe De Sutter, Marleen Temmerman, and Davy Vanden Broeck. 2011. “Bacterial Vaginosis Is Associated with Uterine Cervical Human Papillomavirus Infection: a Meta-analysis.” Bmc Infectious Diseases 11 (10).
APA
Gillet, E., Meys, J., Verstraelen, H., Bosire, C., De Sutter, P., Temmerman, M., & Vanden Broeck, D. (2011). Bacterial vaginosis is associated with uterine cervical human papillomavirus infection: a meta-analysis. BMC INFECTIOUS DISEASES, 11(10).
Vancouver
1.
Gillet E, Meys J, Verstraelen H, Bosire C, De Sutter P, Temmerman M, et al. Bacterial vaginosis is associated with uterine cervical human papillomavirus infection: a meta-analysis. BMC INFECTIOUS DISEASES. 2011;11(10).
MLA
Gillet, Evy, Joris Meys, Hans Verstraelen, et al. “Bacterial Vaginosis Is Associated with Uterine Cervical Human Papillomavirus Infection: a Meta-analysis.” BMC INFECTIOUS DISEASES 11.10 (2011): n. pag. Print.
@article{1843855,
  abstract     = {Background: Bacterial vaginosis (BV), an alteration of vaginal flora involving a decrease in Lactobacilli and predominance of anaerobic bacteria, is among the most common cause of vaginal complaints for women of childbearing age. It is well known that BV has an influence in acquisition of certain genital infections. However, association between BV and cervical human papillomavirus (HPV) infection has been inconsistent among studies. The objective of this meta- analysis of published studies is to clarify and summarize published literature on the extent to which BV is associated with cervical HPV infection. Methods: Medline and Web of Science were systematically searched for eligible publications until December 2009. Articles were selected based on inclusion and exclusion criteria. After testing heterogeneity of studies, meta-analysis was performed using random effect model. Results: Twelve eligible studies were selected to review the association between BV and HPV, including a total of 6,372 women. The pooled prevalence of BV was 32\%. The overall estimated odds ratio (OR) showed a positive association between BV and cervical HPV infection (OR, 1.43; 95\% confidence interval, 1.11-1.84). Conclusion: This meta- analysis of available literature resulted in a positive association between BV and uterine cervical HPV infection.},
  articleno    = {10},
  author       = {Gillet, Evy and Meys, Joris and Verstraelen, Hans and Bosire, Carolyne and De Sutter, Philippe and Temmerman, Marleen and Vanden Broeck, Davy},
  issn         = {1471-2334},
  journal      = {BMC INFECTIOUS DISEASES},
  keyword      = {RISK-FACTORS,NATURAL-HISTORY,CLUE CELLS,WOMEN,SMEARS,DYSBACTERIOSIS,EPIDEMIOLOGY,INTRAEPITHELIAL NEOPLASIA,SIMPLEX-VIRUS TYPE-2,CHLAMYDIA-TRACHOMATIS},
  language     = {eng},
  number       = {10},
  pages        = {9},
  title        = {Bacterial vaginosis is associated with uterine cervical human papillomavirus infection: a meta-analysis},
  url          = {http://dx.doi.org/10.1186/1471-2334-11-10},
  volume       = {11},
  year         = {2011},
}

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