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Cutaneous involvement in children with acute lymphoblastic leukemia or lymphoblastic lymphoma

(1997) PEDIATRICS. 100(1). p.60-64
Author
Organization
Abstract
Objective. Skin involvement in children with acute monocytic leukemia or CD30-positive anaplastic large-cell lymphoma is well-known. In contrast, very little is known about the malignant cutaneous infiltrates in children with acute lymphoblatic leukemia (ALL) or lymphoblastic lymphoma (LBL). This study was designed to determine the frequency of these specific lesions in childhood ALL or LBL and the characteristics of such patients. Design. We studied the clinical and biological findings of children with cutaneous involvement at initial diagnosis of ALL or LBL enrolled between August 1989 and March 1995 in the multicentric trial 58881 of the Children's Leukemia Cooperative Group of the European Organization of Research and Treatment of Cancer (EORTC). Results. Among the 1359 children enrolled in the multicenter trial EORTC 58881, 24 presented with skin involvement at diagnosis. ALL was diagnosed in 15 patients and LBL in 9. In 15 cases, skin lesions were observed within a median time of 6 weeks (range, a few days to 8 months) before the diagnosis of the hematologic disease. Twenty-one children had at least one skin lesion located on the head. Diffuse cutaneous lesions were observed in 7 infants with high-risk ALL. Seventeen of the 24 children remain in the first complete remission (median follow-up of 3 years; range 2 months to 5 years) and 3 are in the second remission with a follow-up of 14 to 24 months. Conclusion. The present study demonstrates that cutaneous involvement can be an early manifestation of ALL or LBL. Cutaneous leukemic infiltrates can be observed in children with standard risk as well as in highrisk ALL. Cutaneous involvement in children with LBL is mainly associated with a B-cell precursor immunophenotype of the lymphomatous cells. The most frequent location of skin lesions in children with ALL or LBL is on the head. Further studies are needed to evaluate the prognosis of children with such involvement at diagnosis.
Keywords
lymphoblastic leukemia, lymphoblastic lymphoma, children, skin leukemia, skin disease, PARAFFIN-EMBEDDED TISSUE, FRANKFURT-MUNSTER GROUP, NON-HODGKINS-LYMPHOMAS, CHILDHOOD, INFANCY

Citation

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Chicago
Millot, F, A Robert, Y Bertrand, F Mechinaud, Genevieve Laureys, A Ferster, P Brock, et al. 1997. “Cutaneous Involvement in Children with Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma.” Pediatrics 100 (1): 60–64.
APA
Millot, F, Robert, A., Bertrand, Y., Mechinaud, F., Laureys, G., Ferster, A., Brock, P., et al. (1997). Cutaneous involvement in children with acute lymphoblastic leukemia or lymphoblastic lymphoma. PEDIATRICS, 100(1), 60–64.
Vancouver
1.
Millot F, Robert A, Bertrand Y, Mechinaud F, Laureys G, Ferster A, et al. Cutaneous involvement in children with acute lymphoblastic leukemia or lymphoblastic lymphoma. PEDIATRICS. 1997;100(1):60–4.
MLA
Millot, F, A Robert, Y Bertrand, et al. “Cutaneous Involvement in Children with Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma.” PEDIATRICS 100.1 (1997): 60–64. Print.
@article{184011,
  abstract     = {Objective. Skin involvement in children with acute monocytic leukemia or CD30-positive anaplastic large-cell lymphoma is well-known. In contrast, very little is known about the malignant cutaneous infiltrates in children with acute lymphoblatic leukemia (ALL) or lymphoblastic lymphoma (LBL). This study was designed to determine the frequency of these specific lesions in childhood ALL or LBL and the characteristics of such patients. 
Design. We studied the clinical and biological findings of children with cutaneous involvement at initial diagnosis of ALL or LBL enrolled between August 1989 and March 1995 in the multicentric trial 58881 of the Children's Leukemia Cooperative Group of the European Organization of Research and Treatment of Cancer (EORTC). 
Results. Among the 1359 children enrolled in the multicenter trial EORTC 58881, 24 presented with skin involvement at diagnosis. ALL was diagnosed in 15 patients and LBL in 9. In 15 cases, skin lesions were observed within a median time of 6 weeks (range, a few days to 8 months) before the diagnosis of the hematologic disease. Twenty-one children had at least one skin lesion located on the head. Diffuse cutaneous lesions were observed in 7 infants with high-risk ALL. Seventeen of the 24 children remain in the first complete remission (median follow-up of 3 years; range 2 months to 5 years) and 3 are in the second remission with a follow-up of 14 to 24 months. 
Conclusion. The present study demonstrates that cutaneous involvement can be an early manifestation of ALL or LBL. Cutaneous leukemic infiltrates can be observed in children with standard risk as well as in highrisk ALL. Cutaneous involvement in children with LBL is mainly associated with a B-cell precursor immunophenotype of the lymphomatous cells. The most frequent location of skin lesions in children with ALL or LBL is on the head. Further studies are needed to evaluate the prognosis of children with such involvement at diagnosis.},
  author       = {Millot, F and Robert, A and Bertrand, Y and Mechinaud, F and Laureys, Genevieve and Ferster, A and Brock, P and Rohrlich, P and Mazingue, F and Plantaz, D and Plouvier, E and Pacquement, H and Behar, C and Rialland, X and Chantraine, JM and Guilhot, F and Otten, J},
  issn         = {0031-4005},
  journal      = {PEDIATRICS},
  keyword      = {lymphoblastic leukemia,lymphoblastic lymphoma,children,skin leukemia,skin disease,PARAFFIN-EMBEDDED TISSUE,FRANKFURT-MUNSTER GROUP,NON-HODGKINS-LYMPHOMAS,CHILDHOOD,INFANCY},
  language     = {eng},
  number       = {1},
  pages        = {60--64},
  title        = {Cutaneous involvement in children with acute lymphoblastic leukemia or lymphoblastic lymphoma},
  volume       = {100},
  year         = {1997},
}