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Prevention of congenital toxoplasmosis in Szeged, Hungary.

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Organization
Abstract
Background. Toxoplasma gondii infection of the fetus can only be discovered or prevented by the appropriate serological screening and subsequent treatment of the mother and her offspring. In Hungary, there is no obligatory toxoplasma screening for pregnant women and both the reporting and follow-up of congenital toxoplasmosis cases is limited. In 1987 we started a systematic study in the Szeged region of Hungary, in which all pregnant women were screened and appropriate treatment given to all mothers and their offspring where congenital toxoplasmosis was suspected. Methods. All pregnant women were routinely screened within the first 16 weeks of gestation;or toxoplasma antibodies by complement fixation test (CFT). Seronegative cases were retested for possible seroconversion every second month, Patients with CFT litres greater than or equal to 1:256 were retested for anti-P30 immunoglobulin A (IgA), IgM and IgG antibodies by ELISA and/or SDS-PAGE-Western immunoblot in order to distinguish the acute and chronic phases of the infection. Results. Up to the end of 1994, the sera of 17 735 gravidae were screened. Ten women were found to have seroconverted during pregnancy and 78 had high initial antibody levels accompanied by anti-P30 IgA antibodies at the very first screening. These two groups together were considered as definitely (10) or possibly (78) infected with Toxoplasma during pregnancy and were treated with Spiramycin. Ali of their offspring were also treated for one month and followed-up by systematic serological and clinical screening for 2 years. No congenital toxoplasmosis was found in any of the offspring. Conclusions. Antenatal, early diagnosis and treatment of toxoplasmosis in mothers, together with treatment and followup of their offspring, may considerably reduce the incidence of the disease in the offspring.

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Chicago
SZENASI, Z, Z OZSVAR, E NAGY, M JESZENSZKY, J SZABO, J GELLEN, M VEGH, and Chris Verhofstede. 1997. “Prevention of Congenital Toxoplasmosis in Szeged, Hungary.” International Journal of Epidemiology 26 (2): 428–435.
APA
SZENASI, Z., OZSVAR, Z., NAGY, E., JESZENSZKY, M., SZABO, J., GELLEN, J., VEGH, M., et al. (1997). Prevention of congenital toxoplasmosis in Szeged, Hungary. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 26(2), 428–435.
Vancouver
1.
SZENASI Z, OZSVAR Z, NAGY E, JESZENSZKY M, SZABO J, GELLEN J, et al. Prevention of congenital toxoplasmosis in Szeged, Hungary. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY. 1997;26(2):428–35.
MLA
SZENASI, Z, Z OZSVAR, E NAGY, et al. “Prevention of Congenital Toxoplasmosis in Szeged, Hungary.” INTERNATIONAL JOURNAL OF EPIDEMIOLOGY 26.2 (1997): 428–435. Print.
@article{183277,
  abstract     = {Background. Toxoplasma gondii infection of the fetus can only be discovered or prevented by the appropriate serological screening and subsequent treatment of the mother and her offspring. In Hungary, there is no obligatory toxoplasma screening for pregnant women and both the reporting and follow-up of congenital toxoplasmosis cases is limited. In 1987 we started a systematic study in the Szeged region of Hungary, in which all pregnant women were screened and appropriate treatment given to all mothers and their offspring where congenital toxoplasmosis was suspected.

Methods. All pregnant women were routinely screened within the first 16 weeks of gestation;or toxoplasma antibodies by complement fixation test (CFT). Seronegative cases were retested for possible seroconversion every second month, Patients with CFT litres greater than or equal to 1:256 were retested for anti-P30 immunoglobulin A (IgA), IgM and IgG antibodies by ELISA and/or SDS-PAGE-Western immunoblot in order to distinguish the acute and chronic phases of the infection.

Results. Up to the end of 1994, the sera of 17 735 gravidae were screened. Ten women were found to have seroconverted during pregnancy and 78 had high initial antibody levels accompanied by anti-P30 IgA antibodies at the very first screening. These two groups together were considered as definitely (10) or possibly (78) infected with Toxoplasma during pregnancy and were treated with Spiramycin. Ali of their offspring were also treated for one month and followed-up by systematic serological and clinical screening for 2 years. No congenital toxoplasmosis was found in any of the offspring.

Conclusions. Antenatal, early diagnosis and treatment of toxoplasmosis in mothers, together with treatment and followup of their offspring, may considerably reduce the incidence of the disease in the offspring.},
  author       = {SZENASI, Z and OZSVAR, Z and NAGY, E and JESZENSZKY, M and SZABO, J and GELLEN, J and VEGH, M and Verhofstede, Chris},
  issn         = {0300-5771},
  journal      = {INTERNATIONAL JOURNAL OF EPIDEMIOLOGY},
  language     = {eng},
  number       = {2},
  pages        = {428--435},
  title        = {Prevention of congenital toxoplasmosis in Szeged, Hungary.},
  volume       = {26},
  year         = {1997},
}