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Peroxisome mosaics in the liver of patients and the regulation of peroxisome expression in rat hepatocyte cultures

Frank Roels (UGent) , Tom Tytgat (UGent) , S Beken, Marisa Giros, Marc Espeel (UGent) , Betty De Prest, Ingrid Kerckaert (UGent) , T Pampols and V Rogiers
(1996) Annals of the New York Academy of Sciences. 804. p.502-515
Author
Organization
Abstract
Peroxisomal deficiency disorders, which are genetically transmitted, are assumed to be expressed in all cells, and the use of cultured skin fibroblasts for diagnosis and research is based on this assumption. We describe four unrelated patients, three boys and a girl, with clinical, biochemical and microscopic evidence of a peroxisomal disorder whose livers display mosaicism, that is, parenchymal cells with peroxisomes are adjacent to cells without peroxisomes. After discussing the possible origin of these mosaics, we examine the influence of the environment on the expression of peroxisomes in adult rat hepatocytes in primary monolayer and three-dimensional culture. In this model the expression of peroxisomes varies between cells and depends upon the culture conditions.
Keywords
CATALASE, ACID, INFANTILE REFSUM-DISEASE, PATHOLOGY, CONFIGURATION

Citation

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MLA
Roels, Frank, et al. “Peroxisome Mosaics in the Liver of Patients and the Regulation of Peroxisome Expression in Rat Hepatocyte Cultures.” Annals of the New York Academy of Sciences, edited by JK Reddy et al., vol. 804, New York Academy of Sciences, 1996, pp. 502–15, doi:10.1111/j.1749-6632.1996.tb18640.x.
APA
Roels, F., Tytgat, T., Beken, S., Giros, M., Espeel, M., De Prest, B., … Rogiers, V. (1996). Peroxisome mosaics in the liver of patients and the regulation of peroxisome expression in rat hepatocyte cultures. Annals of the New York Academy of Sciences, 804, 502–515. https://doi.org/10.1111/j.1749-6632.1996.tb18640.x
Chicago author-date
Roels, Frank, Tom Tytgat, S Beken, Marisa Giros, Marc Espeel, Betty De Prest, Ingrid Kerckaert, T Pampols, and V Rogiers. 1996. “Peroxisome Mosaics in the Liver of Patients and the Regulation of Peroxisome Expression in Rat Hepatocyte Cultures.” Edited by JK Reddy, T Suga, GP Mannaerts, PB Lazarow, and S Subrammani. Annals of the New York Academy of Sciences 804: 502–15. https://doi.org/10.1111/j.1749-6632.1996.tb18640.x.
Chicago author-date (all authors)
Roels, Frank, Tom Tytgat, S Beken, Marisa Giros, Marc Espeel, Betty De Prest, Ingrid Kerckaert, T Pampols, and V Rogiers. 1996. “Peroxisome Mosaics in the Liver of Patients and the Regulation of Peroxisome Expression in Rat Hepatocyte Cultures.” Ed by. JK Reddy, T Suga, GP Mannaerts, PB Lazarow, and S Subrammani. Annals of the New York Academy of Sciences 804: 502–515. doi:10.1111/j.1749-6632.1996.tb18640.x.
Vancouver
1.
Roels F, Tytgat T, Beken S, Giros M, Espeel M, De Prest B, et al. Peroxisome mosaics in the liver of patients and the regulation of peroxisome expression in rat hepatocyte cultures. Reddy J, Suga T, Mannaerts G, Lazarow P, Subrammani S, editors. Annals of the New York Academy of Sciences. 1996;804:502–15.
IEEE
[1]
F. Roels et al., “Peroxisome mosaics in the liver of patients and the regulation of peroxisome expression in rat hepatocyte cultures,” Annals of the New York Academy of Sciences, vol. 804, pp. 502–515, 1996.
@article{182334,
  abstract     = {{Peroxisomal deficiency disorders, which are genetically transmitted, are assumed to be expressed in all cells, and the use of cultured skin fibroblasts for diagnosis and research is based on this assumption. We describe four unrelated patients, three boys and a girl, with clinical, biochemical and microscopic evidence of a peroxisomal disorder whose livers display mosaicism, that is, parenchymal cells with peroxisomes are adjacent to cells without peroxisomes. After discussing the possible origin of these mosaics, we examine the influence of the environment on the expression of peroxisomes in adult rat hepatocytes in primary monolayer and three-dimensional culture. In this model the expression of peroxisomes varies between cells and depends upon the culture conditions.}},
  author       = {{Roels, Frank and Tytgat, Tom and Beken, S and Giros, Marisa and Espeel, Marc and De Prest, Betty and Kerckaert, Ingrid and Pampols, T and Rogiers, V}},
  editor       = {{Reddy, JK and Suga, T and Mannaerts, GP and Lazarow, PB and Subrammani, S}},
  issn         = {{0077-8923}},
  journal      = {{Annals of the New York Academy of Sciences}},
  keywords     = {{CATALASE,ACID,INFANTILE REFSUM-DISEASE,PATHOLOGY,CONFIGURATION}},
  language     = {{eng}},
  location     = {{Aspen, CO, USA}},
  pages        = {{502--515}},
  publisher    = {{New York Academy of Sciences}},
  title        = {{Peroxisome mosaics in the liver of patients and the regulation of peroxisome expression in rat hepatocyte cultures}},
  url          = {{http://doi.org/10.1111/j.1749-6632.1996.tb18640.x}},
  volume       = {{804}},
  year         = {{1996}},
}
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