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Peroxisome mosaics in the liver of patients and the regulation of peroxisome expression in rat hepatocyte cultures

Frank Roels, Tom Tytgat UGent, S Beken, Marisa Giros, Marc Espeel, Betty De Prest, Ingrid Kerckaert UGent, T Pampols and V Rogiers (1996) Annals of the New York Academy of Sciences. 804. p.502-515
abstract
Peroxisomal deficiency disorders, which are genetically transmitted, are assumed to be expressed in all cells, and the use of cultured skin fibroblasts for diagnosis and research is based on this assumption. We describe four unrelated patients, three boys and a girl, with clinical, biochemical and microscopic evidence of a peroxisomal disorder whose livers display mosaicism, that is, parenchymal cells with peroxisomes are adjacent to cells without peroxisomes. After discussing the possible origin of these mosaics, we examine the influence of the environment on the expression of peroxisomes in adult rat hepatocytes in primary monolayer and three-dimensional culture. In this model the expression of peroxisomes varies between cells and depends upon the culture conditions.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
CATALASE, ACID, INFANTILE REFSUM-DISEASE, PATHOLOGY, CONFIGURATION
journal title
Annals of the New York Academy of Sciences
Ann. N.Y. Acad. Sci.
editor
JK Reddy, T Suga, GP Mannaerts, PB Lazarow and S Subrammani
volume
804
issue title
Peroxisomes : biology and role in toxicology and disease
pages
502 - 515
publisher
New York Academy of Sciences
place of publication
New York, NY, USA
conference name
International symposium on Peroxisomes : Biology and role in toxicology and disease
conference location
Aspen, CO, USA
conference start
1995-06-28
conference end
1995-07-02
Web of Science type
Article
ISSN
0077-8923
DOI
10.1111/j.1749-6632.1996.tb18640.x
language
English
UGent publication?
yes
classification
A1
id
182334
handle
http://hdl.handle.net/1854/LU-182334
date created
2004-01-14 13:41:00
date last changed
2017-09-05 09:24:05
@article{182334,
  abstract     = {Peroxisomal deficiency disorders, which are genetically transmitted, are assumed to be expressed in all cells, and the use of cultured skin fibroblasts for diagnosis and research is based on this assumption. We describe four unrelated patients, three boys and a girl, with clinical, biochemical and microscopic evidence of a peroxisomal disorder whose livers display mosaicism, that is, parenchymal cells with peroxisomes are adjacent to cells without peroxisomes. After discussing the possible origin of these mosaics, we examine the influence of the environment on the expression of peroxisomes in adult rat hepatocytes in primary monolayer and three-dimensional culture. In this model the expression of peroxisomes varies between cells and depends upon the culture conditions.},
  author       = {Roels, Frank and Tytgat, Tom and Beken, S and Giros, Marisa and Espeel, Marc and De Prest, Betty and Kerckaert, Ingrid and Pampols, T and Rogiers, V},
  editor       = {Reddy, JK and Suga, T and Mannaerts, GP and Lazarow, PB and Subrammani, S},
  issn         = {0077-8923},
  journal      = {Annals of the New York Academy of Sciences},
  keyword      = {CATALASE,ACID,INFANTILE REFSUM-DISEASE,PATHOLOGY,CONFIGURATION},
  language     = {eng},
  location     = {Aspen, CO, USA},
  pages        = {502--515},
  publisher    = {New York Academy of Sciences},
  title        = {Peroxisome mosaics in the liver of patients and the regulation of peroxisome expression in rat hepatocyte cultures},
  url          = {http://dx.doi.org/10.1111/j.1749-6632.1996.tb18640.x},
  volume       = {804},
  year         = {1996},
}

Chicago
Roels, Frank, Tom Tytgat, S Beken, Marisa Giros, Marc Espeel, Betty De Prest, Ingrid Kerckaert, T Pampols, and V Rogiers. 1996. “Peroxisome Mosaics in the Liver of Patients and the Regulation of Peroxisome Expression in Rat Hepatocyte Cultures.” Ed. JK Reddy, T Suga, GP Mannaerts, PB Lazarow, and S Subrammani. Annals of the New York Academy of Sciences 804: 502–515.
APA
Roels, F., Tytgat, T., Beken, S., Giros, M., Espeel, M., De Prest, B., Kerckaert, I., et al. (1996). Peroxisome mosaics in the liver of patients and the regulation of peroxisome expression in rat hepatocyte cultures. (J. Reddy, T. Suga, G. Mannaerts, P. Lazarow, & S. Subrammani, Eds.)Annals of the New York Academy of Sciences, 804, 502–515. Presented at the International symposium on Peroxisomes : Biology and role in toxicology and disease.
Vancouver
1.
Roels F, Tytgat T, Beken S, Giros M, Espeel M, De Prest B, et al. Peroxisome mosaics in the liver of patients and the regulation of peroxisome expression in rat hepatocyte cultures. Reddy J, Suga T, Mannaerts G, Lazarow P, Subrammani S, editors. Annals of the New York Academy of Sciences. New York, NY, USA: New York Academy of Sciences; 1996;804:502–15.
MLA
Roels, Frank, Tom Tytgat, S Beken, et al. “Peroxisome Mosaics in the Liver of Patients and the Regulation of Peroxisome Expression in Rat Hepatocyte Cultures.” Ed. JK Reddy et al. Annals of the New York Academy of Sciences 804 (1996): 502–515. Print.