Broxaterol increases force output of fatigued canine diaphragm more than salbutamol
- Author
- Eric Derom (UGent) , Ghislaine Gayan-Ramirez, Giovanni Gurrieri, Vera de Bock and Marc Decramer
- Organization
- Abstract
- We previously demonstrated that broxaterol enhanced recovery of fatigued canine diaphragm. The aim of this study was to compare the inotropic effects of salbutamol and broxaterol on fatigued canine diaphragm. Low-frequency fatigue was induced in 14 mongrel dogs by electrophrenic stimulation, which was continued until transdiaphragmatic pressure (Pdi) at 20 Hz was reduced by 50% or for 1 h. After stabilization of fatigue, the animals received a bolus (18.5 mu g/kg) of either broxaterol or salbutamol, followed by a continuous infusion (0.43 mu g/kg/min). A second bolus of 74.0 mu g/kg, followed by a continuous infusion of 1.72 mu g/kg/min, was given after 90 min. Both drugs significantly increased twitch Pdi. Twitch Pdi measured 90 min after the first and second doses of broxaterol increased by 28 +/- 23% and 42 +/- 34%, respectively, whereas the salbutamol-induced increase was clearly smaller (9 +/- 10% and 17 +/- 15%, respectively). Broxaterol increased Pdi at 20 Hz by 25 +/- 28% with the first dose and by 29 +/- 21% with the second dose. In contrast, salbutamol did not alter Pdi at 20 Hz. Neither drug affected Pdi at 100 Hz. We conclude that broxaterol promoted recovery of low-frequency fatigue of the canine diaphragm in vivo in a dose-dependent manner, whereas salbutamol only minimally improved force production by the fatigued diaphragm.
- Keywords
- SKELETAL-MUSCLE, MOUSE MUSCLE-FIBERS, BLOOD-FLOW, MECHANISM, CONTRACTILITY, STIMULATION
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-181619
- MLA
- Derom, Eric, Ghislaine Gayan-Ramirez, Giovanni Gurrieri, et al. “Broxaterol Increases Force Output of Fatigued Canine Diaphragm More Than Salbutamol.” AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 155.1 (1997): 181–185. Print.
- APA
- Derom, E., Gayan-Ramirez, G., Gurrieri, G., de Bock, V., & Decramer, M. (1997). Broxaterol increases force output of fatigued canine diaphragm more than salbutamol. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 155(1), 181–185.
- Chicago author-date
- Derom, Eric, Ghislaine Gayan-Ramirez, Giovanni Gurrieri, Vera de Bock, and Marc Decramer. 1997. “Broxaterol Increases Force Output of Fatigued Canine Diaphragm More Than Salbutamol.” American Journal of Respiratory and Critical Care Medicine 155 (1): 181–185.
- Chicago author-date (all authors)
- Derom, Eric, Ghislaine Gayan-Ramirez, Giovanni Gurrieri, Vera de Bock, and Marc Decramer. 1997. “Broxaterol Increases Force Output of Fatigued Canine Diaphragm More Than Salbutamol.” American Journal of Respiratory and Critical Care Medicine 155 (1): 181–185.
- Vancouver
- 1.Derom E, Gayan-Ramirez G, Gurrieri G, de Bock V, Decramer M. Broxaterol increases force output of fatigued canine diaphragm more than salbutamol. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 1997;155(1):181–5.
- IEEE
- [1]E. Derom, G. Gayan-Ramirez, G. Gurrieri, V. de Bock, and M. Decramer, “Broxaterol increases force output of fatigued canine diaphragm more than salbutamol,” AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, vol. 155, no. 1, pp. 181–185, 1997.
@article{181619,
abstract = {We previously demonstrated that broxaterol enhanced recovery of fatigued canine diaphragm. The aim of this study was to compare the inotropic effects of salbutamol and broxaterol on fatigued canine diaphragm. Low-frequency fatigue was induced in 14 mongrel dogs by electrophrenic stimulation, which was continued until transdiaphragmatic pressure (Pdi) at 20 Hz was reduced by 50% or for 1 h. After stabilization of fatigue, the animals received a bolus (18.5 mu g/kg) of either broxaterol or salbutamol, followed by a continuous infusion (0.43 mu g/kg/min). A second bolus of 74.0 mu g/kg, followed by a continuous infusion of 1.72 mu g/kg/min, was given after 90 min. Both drugs significantly increased twitch Pdi. Twitch Pdi measured 90 min after the first and second doses of broxaterol increased by 28 +/- 23% and 42 +/- 34%, respectively, whereas the salbutamol-induced increase was clearly smaller (9 +/- 10% and 17 +/- 15%, respectively). Broxaterol increased Pdi at 20 Hz by 25 +/- 28% with the first dose and by 29 +/- 21% with the second dose. In contrast, salbutamol did not alter Pdi at 20 Hz. Neither drug affected Pdi at 100 Hz. We conclude that broxaterol promoted recovery of low-frequency fatigue of the canine diaphragm in vivo in a dose-dependent manner, whereas salbutamol only minimally improved force production by the fatigued diaphragm.},
author = {Derom, Eric and Gayan-Ramirez, Ghislaine and Gurrieri, Giovanni and de Bock, Vera and Decramer, Marc},
issn = {1073-449X},
journal = {AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE},
keywords = {SKELETAL-MUSCLE,MOUSE MUSCLE-FIBERS,BLOOD-FLOW,MECHANISM,CONTRACTILITY,STIMULATION},
language = {eng},
number = {1},
pages = {181--185},
title = {Broxaterol increases force output of fatigued canine diaphragm more than salbutamol},
url = {http://ajrccm.atsjournals.org/cgi/content/abstract/155/1/181},
volume = {155},
year = {1997},
}