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Enrichment of T cells carrying 137 integrins in inflamed synovial tissue from patients with early spondyloarthropathy, compared to rheumatoid arthritis

Dirk Elewaut (UGent) , Filip De Keyser (UGent) , Filip Van den Bosch (UGent) , AI Lazarovits, Martine De Vos (UGent) , Claude Cuvelier (UGent) , August Verbruggen (UGent) , Herman Mielants (UGent) and Eric Veys (UGent)
(1998) JOURNAL OF RHEUMATOLOGY. 25(10). p.1932-1937
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Organization
Abstract
Objective. To compare the expression of adhesion molecules on synovial T cells from patients with early spondyloarthropathy (SpA) and rheumatoid arthritis (RA), with special reference to the beta 7 integrins alpha 4 beta 7 and alpha E beta 7 in view of their intimate association with intestinal tissue. Methods. Twenty-five synovial cell lines were generated by interleukin 2 (IL-2) expansion from synovial biopsies of patients with early SpA and RA, obtained from macroscopically inflamed synovial tissue by needle arthroscopy, and subsequently characterized by now cytometry for CD3, CD3, CD8, L-selectin, CD11a, CD31, CD44, and alpha 4 beta 7 and alpha E beta 7 integrin. Results. In SpA, the beta 7 integrin expression was increased, compared to RA. Furthermore, an inverse relation between alpha 4 beta 7 and alpha E beta 7 was present in SpA (r = -0.75, p < 0.02), as on many mucosal T cells. In contrast, an opposite correlation was noted in RA (r = +0.84, p < 0.01), as similarly described on a subset of circulating T cells. Conclusion. Increased expression of beta 7 integrins was noted on synovial T cell lines from SpA compared to RA, with discriminative correlations between alpha 4 beta 7 and alpha E beta 7. This suggests a different origin of the synovial T cells in these diseases.
Keywords
ADHESION MOLECULE-1, PERIPHERAL-BLOOD, INFLAMMATORY DISEASE, DIFFERENTIAL EXPRESSION, HLA-B27 TRANSGENIC RATS, synovium, spondyloarthropathies, beta 7 integrins, MUCOSAL, FLUID, BINDING, GUT, LYMPHOCYTES

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Chicago
Elewaut, Dirk, Filip De Keyser, Filip Van den Bosch, AI Lazarovits, Martine De Vos, Claude Cuvelier, August Verbruggen, Herman Mielants, and Eric Veys. 1998. “Enrichment of T Cells Carrying 137 Integrins in Inflamed Synovial Tissue from Patients with Early Spondyloarthropathy, Compared to Rheumatoid Arthritis.” Journal of Rheumatology 25 (10): 1932–1937.
APA
Elewaut, D., De Keyser, F., Van den Bosch, F., Lazarovits, A., De Vos, M., Cuvelier, C., Verbruggen, A., et al. (1998). Enrichment of T cells carrying 137 integrins in inflamed synovial tissue from patients with early spondyloarthropathy, compared to rheumatoid arthritis. JOURNAL OF RHEUMATOLOGY, 25(10), 1932–1937.
Vancouver
1.
Elewaut D, De Keyser F, Van den Bosch F, Lazarovits A, De Vos M, Cuvelier C, et al. Enrichment of T cells carrying 137 integrins in inflamed synovial tissue from patients with early spondyloarthropathy, compared to rheumatoid arthritis. JOURNAL OF RHEUMATOLOGY. 1998;25(10):1932–7.
MLA
Elewaut, Dirk, Filip De Keyser, Filip Van den Bosch, et al. “Enrichment of T Cells Carrying 137 Integrins in Inflamed Synovial Tissue from Patients with Early Spondyloarthropathy, Compared to Rheumatoid Arthritis.” JOURNAL OF RHEUMATOLOGY 25.10 (1998): 1932–1937. Print.
@article{180057,
  abstract     = {Objective. To compare the expression of adhesion molecules on synovial T cells from patients with early spondyloarthropathy (SpA) and rheumatoid arthritis (RA), with special reference to the beta 7 integrins alpha 4 beta 7 and alpha E beta 7 in view of their intimate association with intestinal tissue. 
Methods. Twenty-five synovial cell lines were generated by interleukin 2 (IL-2) expansion from synovial biopsies of patients with early SpA and RA, obtained from macroscopically inflamed synovial tissue by needle arthroscopy, and subsequently characterized by now cytometry for CD3, CD3, CD8, L-selectin, CD11a, CD31, CD44, and alpha 4 beta 7 and alpha E beta 7 integrin. 
Results. In SpA, the beta 7 integrin expression was increased, compared to RA. Furthermore, an inverse relation between alpha 4 beta 7 and alpha E beta 7 was present in SpA (r = -0.75, p {\textlangle} 0.02), as on many mucosal T cells. In contrast, an opposite correlation was noted in RA (r = +0.84, p {\textlangle} 0.01), as similarly described on a subset of circulating T cells. 
Conclusion. Increased expression of beta 7 integrins was noted on synovial T cell lines from SpA compared to RA, with discriminative correlations between alpha 4 beta 7 and alpha E beta 7. This suggests a different origin of the synovial T cells in these diseases.},
  author       = {Elewaut, Dirk and De Keyser, Filip and Van den Bosch, Filip and Lazarovits, AI and De Vos, Martine and Cuvelier, Claude and Verbruggen, August and Mielants, Herman and Veys, Eric},
  issn         = {0315-162X},
  journal      = {JOURNAL OF RHEUMATOLOGY},
  keyword      = {ADHESION MOLECULE-1,PERIPHERAL-BLOOD,INFLAMMATORY DISEASE,DIFFERENTIAL EXPRESSION,HLA-B27 TRANSGENIC RATS,synovium,spondyloarthropathies,beta 7 integrins,MUCOSAL,FLUID,BINDING,GUT,LYMPHOCYTES},
  language     = {eng},
  number       = {10},
  pages        = {1932--1937},
  title        = {Enrichment of T cells carrying 137 integrins in inflamed synovial tissue from patients with early spondyloarthropathy, compared to rheumatoid arthritis},
  volume       = {25},
  year         = {1998},
}

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