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Distinctive activated cellular subsets in colon from patients with Crohn's disease and ulcerative colitis

Dirk Elewaut (UGent) , Filip De Keyser (UGent) , Claude Cuvelier (UGent) , AI Lazarovits, Herman Mielants (UGent) , August Verbruggen (UGent) , S Sas, Martine De Vos (UGent) and Eric Veys (UGent)
Author
Organization
Abstract
Background: Activated lymphocytes are considered to play a pathogenic role in Crohn's disease (CD) and ulcerative colitis (UC), although only a limited fraction of the gut-residing lymphocytes in these diseases may be pathogenetically involved, due to active recruitment from the peripheral circulation. Our aim was to characterize in situ preactivated lymphocytes in inflammatory bowel disease mucosa by expansion with interleukin-2. Methods: Flow cytometry was performed on T cells expanded from the colon of patients with CD (7), UC (16), and controls (20), with special reference to T-cell activation markers and adhesion molecules. Results: In CD a decrease in alpha 4 beta 7 integrin expression was associated with an increase in alpha E beta 7. In UC a similar increase in alpha E beta 7 was observed. Moreover, L-selectin and CD30 were overexpressed on T helper cells in UC versus CD. Conclusion: These findings indicate different immunopathogenic pathways for CD and UC.
Keywords
inflammatory bowel disease, adhesion molecules, interleukin-2, T-cell activation, INFLAMMATORY BOWEL-DISEASE, VASCULAR ADHESION MOLECULES, CD4(+) T-CELLS, INTERLEUKIN-2 RECEPTOR, INCREASED EXPRESSION, LYMPHOCYTES, INTEGRIN, MUCOSA, RECRUITMENT, SELECTIN

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MLA
Elewaut, Dirk, Filip De Keyser, Claude Cuvelier, et al. “Distinctive Activated Cellular Subsets in Colon from Patients with Crohn’s Disease and Ulcerative Colitis.” SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY 33.7 (1998): 743–748. Print.
APA
Elewaut, D., De Keyser, F., Cuvelier, C., Lazarovits, A., Mielants, H., Verbruggen, A., Sas, S., et al. (1998). Distinctive activated cellular subsets in colon from patients with Crohn’s disease and ulcerative colitis. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 33(7), 743–748.
Chicago author-date
Elewaut, Dirk, Filip De Keyser, Claude Cuvelier, AI Lazarovits, Herman Mielants, August Verbruggen, S Sas, Martine De Vos, and Eric Veys. 1998. “Distinctive Activated Cellular Subsets in Colon from Patients with Crohn’s Disease and Ulcerative Colitis.” Scandinavian Journal of Gastroenterology 33 (7): 743–748.
Chicago author-date (all authors)
Elewaut, Dirk, Filip De Keyser, Claude Cuvelier, AI Lazarovits, Herman Mielants, August Verbruggen, S Sas, Martine De Vos, and Eric Veys. 1998. “Distinctive Activated Cellular Subsets in Colon from Patients with Crohn’s Disease and Ulcerative Colitis.” Scandinavian Journal of Gastroenterology 33 (7): 743–748.
Vancouver
1.
Elewaut D, De Keyser F, Cuvelier C, Lazarovits A, Mielants H, Verbruggen A, et al. Distinctive activated cellular subsets in colon from patients with Crohn’s disease and ulcerative colitis. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY. 1998;33(7):743–8.
IEEE
[1]
D. Elewaut et al., “Distinctive activated cellular subsets in colon from patients with Crohn’s disease and ulcerative colitis,” SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, vol. 33, no. 7, pp. 743–748, 1998.
@article{179244,
  abstract     = {Background: Activated lymphocytes are considered to play a pathogenic role in Crohn's disease (CD) and ulcerative colitis (UC), although only a limited fraction of the gut-residing lymphocytes in these diseases may be pathogenetically involved, due to active recruitment from the peripheral circulation. Our aim was to characterize in situ preactivated lymphocytes in inflammatory bowel disease mucosa by expansion with interleukin-2.
Methods: Flow cytometry was performed on T cells expanded from the colon of patients with CD (7), UC (16), and controls (20), with special reference to T-cell activation markers and adhesion molecules.
Results: In CD a decrease in alpha 4 beta 7 integrin expression was associated with an increase in alpha E beta 7. In UC a similar increase in alpha E beta 7 was observed. Moreover, L-selectin and CD30 were overexpressed on T helper cells in UC versus CD.
Conclusion: These findings indicate different immunopathogenic pathways for CD and UC.},
  author       = {Elewaut, Dirk and De Keyser, Filip and Cuvelier, Claude and Lazarovits, AI and Mielants, Herman and Verbruggen, August and Sas, S and De Vos, Martine and Veys, Eric},
  issn         = {0036-5521},
  journal      = {SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY},
  keywords     = {inflammatory bowel disease,adhesion molecules,interleukin-2,T-cell activation,INFLAMMATORY BOWEL-DISEASE,VASCULAR ADHESION MOLECULES,CD4(+) T-CELLS,INTERLEUKIN-2 RECEPTOR,INCREASED EXPRESSION,LYMPHOCYTES,INTEGRIN,MUCOSA,RECRUITMENT,SELECTIN},
  language     = {eng},
  number       = {7},
  pages        = {743--748},
  title        = {Distinctive activated cellular subsets in colon from patients with Crohn's disease and ulcerative colitis},
  volume       = {33},
  year         = {1998},
}

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