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Pharmacokinetics and efficacy of amoxycillin in the treatment of an experimental Streptococcus bovis infection in racing pigeons (Columba livia)

Johanna Soenens, H Vermeersch, Kris Baert UGent, Brenda Vermeulen UGent, Hans Nelis UGent, Patrick Butaye UGent, Peter De Herdt UGent, Jean Paul Remon UGent and Patrick De Backer UGent (1998) VETERINARY JOURNAL. 156(1). p.59-65
abstract
The pharmacokinetics of amoxycillin in pigeons (Columba livia) and the efficacy of amoxycillin treatment in pigeon streptococcosis, were investigated. After intravenous administration of 150mg.kg(-1) amoxycillin, the drug plasma concentration-time profile fitted an open two-compartment model. Amoxycillin was quickly cleared from the circulation with a mean half-life of 66min and showed a distribution volume of 0.9L.kg(-1) The absolute oral bioavailability of amoxycillin was 50.1 %. A 5-day drinking water treatment with amoxycillin (1500mg.L-1, corresponding to 112.0mg.kg(-1).day(-1) during day-light hours) significantly reduced the postinoculation morbidity in pigeons experimentally infected with Streptococcus bovis, compared to untreated infected controls.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
pigeon, amoxycillin, pharmacokinetics, efficacy, Streptococcus bovis
journal title
VETERINARY JOURNAL
Vet. J.
volume
156
issue
1
pages
59 - 65
Web of Science type
Article
Web of Science id
000074890700010
ISSN
1090-0233
DOI
10.1016/S1090-0233(98)80062-2
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
179174
handle
http://hdl.handle.net/1854/LU-179174
date created
2004-01-14 13:41:00
date last changed
2010-07-15 10:08:50
@article{179174,
  abstract     = {The pharmacokinetics of amoxycillin in pigeons (Columba livia) and the efficacy of amoxycillin treatment in pigeon streptococcosis, were investigated. After intravenous administration of 150mg.kg(-1) amoxycillin, the drug plasma concentration-time profile fitted an open two-compartment model. Amoxycillin was quickly cleared from the circulation with a mean half-life of 66min and showed a distribution volume of 0.9L.kg(-1) The absolute oral bioavailability of amoxycillin was 50.1 \%. A 5-day drinking water treatment with amoxycillin (1500mg.L-1, corresponding to 112.0mg.kg(-1).day(-1) during day-light hours) significantly reduced the postinoculation morbidity in pigeons experimentally infected with Streptococcus bovis, compared to untreated infected controls.},
  author       = {Soenens, Johanna and Vermeersch, H and Baert, Kris and Vermeulen, Brenda and Nelis, Hans and Butaye, Patrick and De Herdt, Peter and Remon, Jean Paul and De Backer, Patrick},
  issn         = {1090-0233},
  journal      = {VETERINARY JOURNAL},
  keyword      = {pigeon,amoxycillin,pharmacokinetics,efficacy,Streptococcus bovis},
  language     = {eng},
  number       = {1},
  pages        = {59--65},
  title        = {Pharmacokinetics and efficacy of amoxycillin in the treatment of an experimental Streptococcus bovis infection in racing pigeons (Columba livia)},
  url          = {http://dx.doi.org/10.1016/S1090-0233(98)80062-2},
  volume       = {156},
  year         = {1998},
}

Chicago
Soenens, Johanna, H Vermeersch, Kris Baert, Brenda Vermeulen, Hans Nelis, Patrick Butaye, Peter De Herdt, Jean Paul Remon, and Patrick De Backer. 1998. “Pharmacokinetics and Efficacy of Amoxycillin in the Treatment of an Experimental Streptococcus Bovis Infection in Racing Pigeons (Columba Livia).” Veterinary Journal 156 (1): 59–65.
APA
Soenens, J., Vermeersch, H., Baert, K., Vermeulen, B., Nelis, H., Butaye, P., De Herdt, P., et al. (1998). Pharmacokinetics and efficacy of amoxycillin in the treatment of an experimental Streptococcus bovis infection in racing pigeons (Columba livia). VETERINARY JOURNAL, 156(1), 59–65.
Vancouver
1.
Soenens J, Vermeersch H, Baert K, Vermeulen B, Nelis H, Butaye P, et al. Pharmacokinetics and efficacy of amoxycillin in the treatment of an experimental Streptococcus bovis infection in racing pigeons (Columba livia). VETERINARY JOURNAL. 1998;156(1):59–65.
MLA
Soenens, Johanna, H Vermeersch, Kris Baert, et al. “Pharmacokinetics and Efficacy of Amoxycillin in the Treatment of an Experimental Streptococcus Bovis Infection in Racing Pigeons (Columba Livia).” VETERINARY JOURNAL 156.1 (1998): 59–65. Print.