Development of immunity to Mecistocirrus digitatus (Nematoda: Trichostrongylidae) in calves
- Author
- Dirk Van Aken, Jozef Vercruysse (UGent) , A Dargantes, L Valdez, A Flores and Darren Shaw
- Organization
- Abstract
- The importance of the third (L-3), fourth (L-4) and adult stages of Mecistocirrus digitatuts in inducing resistance to reinfection was examined. Three groups of 5 calves (A, B, C) were immunized for 2 consecutive days with a daily dose of 20 000 M. digitatus infectious larvae. Group A was treated with ivermectin 7 days post-infection (exposed to L-3), group B was treated after 26 days (exposed to L-3 and L-4) and group C after 60 days (exposed to L-3, L-4 and adults). Thirty days posttreatment, animals were challenged with 30 000 M. digitatus L-3. Five previously uninfected control animals (group D) also received 30 000 L-3. All animals were necropsied 75 days post-challenge. Increases in exposure to the immunizing infection resulted in significant increases in the pre-patent period post-challenge; 54 days in the controls, compared with 63, 70 and 72 days for groups A, B and C, respectively. Only adult worms were recovered at necropsy, and the mean number of worms significantly increased with increasing exposure to the immunizing infection: 355 in the controls, compared to 481, 937 and 1174 in groups A, B and C, respectively. No significant changes in worm length were observed. Infection with M. digitatus significantly affects a subsequent challenge infection - stimulation of the immune system by exposure to L-3 extends the pre-patent period, and suppression by later stages (L-4, adult) leads to higher worm burdens.
- Keywords
- Mecistocirrus digitatus, cattle, Nematoda, abbreviated infections, immunity, ivermectin, third-stage larvae (L-3), fourth-stage larvae (L-4), INFECTIONS, CATTLE
Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-179148
- MLA
- Van Aken, Dirk, et al. “Development of Immunity to Mecistocirrus Digitatus (Nematoda: Trichostrongylidae) in Calves.” PARASITOLOGY, vol. 117, no. 1, 1998, pp. 83–87.
- APA
- Van Aken, D., Vercruysse, J., Dargantes, A., Valdez, L., Flores, A., & Shaw, D. (1998). Development of immunity to Mecistocirrus digitatus (Nematoda: Trichostrongylidae) in calves. PARASITOLOGY, 117(1), 83–87.
- Chicago author-date
- Van Aken, Dirk, Jozef Vercruysse, A Dargantes, L Valdez, A Flores, and Darren Shaw. 1998. “Development of Immunity to Mecistocirrus Digitatus (Nematoda: Trichostrongylidae) in Calves.” PARASITOLOGY 117 (1): 83–87.
- Chicago author-date (all authors)
- Van Aken, Dirk, Jozef Vercruysse, A Dargantes, L Valdez, A Flores, and Darren Shaw. 1998. “Development of Immunity to Mecistocirrus Digitatus (Nematoda: Trichostrongylidae) in Calves.” PARASITOLOGY 117 (1): 83–87.
- Vancouver
- 1.Van Aken D, Vercruysse J, Dargantes A, Valdez L, Flores A, Shaw D. Development of immunity to Mecistocirrus digitatus (Nematoda: Trichostrongylidae) in calves. PARASITOLOGY. 1998;117(1):83–7.
- IEEE
- [1]D. Van Aken, J. Vercruysse, A. Dargantes, L. Valdez, A. Flores, and D. Shaw, “Development of immunity to Mecistocirrus digitatus (Nematoda: Trichostrongylidae) in calves,” PARASITOLOGY, vol. 117, no. 1, pp. 83–87, 1998.
@article{179148,
abstract = {{The importance of the third (L-3), fourth (L-4) and adult stages of Mecistocirrus digitatuts in inducing resistance to reinfection was examined. Three groups of 5 calves (A, B, C) were immunized for 2 consecutive days with a daily dose of 20 000 M. digitatus infectious larvae. Group A was treated with ivermectin 7 days post-infection (exposed to L-3), group B was treated after 26 days (exposed to L-3 and L-4) and group C after 60 days (exposed to L-3, L-4 and adults). Thirty days posttreatment, animals were challenged with 30 000 M. digitatus L-3. Five previously uninfected control animals (group D) also received 30 000 L-3. All animals were necropsied 75 days post-challenge. Increases in exposure to the immunizing infection resulted in significant increases in the pre-patent period post-challenge; 54 days in the controls, compared with 63, 70 and 72 days for groups A, B and C, respectively. Only adult worms were recovered at necropsy, and the mean number of worms significantly increased with increasing exposure to the immunizing infection: 355 in the controls, compared to 481, 937 and 1174 in groups A, B and C, respectively. No significant changes in worm length were observed. Infection with M. digitatus significantly affects a subsequent challenge infection - stimulation of the immune system by exposure to L-3 extends the pre-patent period, and suppression by later stages (L-4, adult) leads to higher worm burdens.}},
author = {{Van Aken, Dirk and Vercruysse, Jozef and Dargantes, A and Valdez, L and Flores, A and Shaw, Darren}},
issn = {{0031-1820}},
journal = {{PARASITOLOGY}},
keywords = {{Mecistocirrus digitatus,cattle,Nematoda,abbreviated infections,immunity,ivermectin,third-stage larvae (L-3),fourth-stage larvae (L-4),INFECTIONS,CATTLE}},
language = {{eng}},
number = {{1}},
pages = {{83--87}},
title = {{Development of immunity to Mecistocirrus digitatus (Nematoda: Trichostrongylidae) in calves}},
volume = {{117}},
year = {{1998}},
}