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Development of immunity to Mecistocirrus digitatus (Nematoda: Trichostrongylidae) in calves

(1998) PARASITOLOGY. 117(1). p.83-87
Author
Organization
Abstract
The importance of the third (L-3), fourth (L-4) and adult stages of Mecistocirrus digitatuts in inducing resistance to reinfection was examined. Three groups of 5 calves (A, B, C) were immunized for 2 consecutive days with a daily dose of 20 000 M. digitatus infectious larvae. Group A was treated with ivermectin 7 days post-infection (exposed to L-3), group B was treated after 26 days (exposed to L-3 and L-4) and group C after 60 days (exposed to L-3, L-4 and adults). Thirty days posttreatment, animals were challenged with 30 000 M. digitatus L-3. Five previously uninfected control animals (group D) also received 30 000 L-3. All animals were necropsied 75 days post-challenge. Increases in exposure to the immunizing infection resulted in significant increases in the pre-patent period post-challenge; 54 days in the controls, compared with 63, 70 and 72 days for groups A, B and C, respectively. Only adult worms were recovered at necropsy, and the mean number of worms significantly increased with increasing exposure to the immunizing infection: 355 in the controls, compared to 481, 937 and 1174 in groups A, B and C, respectively. No significant changes in worm length were observed. Infection with M. digitatus significantly affects a subsequent challenge infection - stimulation of the immune system by exposure to L-3 extends the pre-patent period, and suppression by later stages (L-4, adult) leads to higher worm burdens.
Keywords
Mecistocirrus digitatus, cattle, Nematoda, abbreviated infections, immunity, ivermectin, third-stage larvae (L-3), fourth-stage larvae (L-4), INFECTIONS, CATTLE

Citation

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MLA
Van Aken, Dirk, Jozef Vercruysse, A Dargantes, et al. “Development of Immunity to Mecistocirrus Digitatus (Nematoda: Trichostrongylidae) in Calves.” PARASITOLOGY 117.1 (1998): 83–87. Print.
APA
Van Aken, D., Vercruysse, J., Dargantes, A., Valdez, L., Flores, A., & Shaw, D. (1998). Development of immunity to Mecistocirrus digitatus (Nematoda: Trichostrongylidae) in calves. PARASITOLOGY, 117(1), 83–87.
Chicago author-date
Van Aken, Dirk, Jozef Vercruysse, A Dargantes, L Valdez, A Flores, and Darren Shaw. 1998. “Development of Immunity to Mecistocirrus Digitatus (Nematoda: Trichostrongylidae) in Calves.” Parasitology 117 (1): 83–87.
Chicago author-date (all authors)
Van Aken, Dirk, Jozef Vercruysse, A Dargantes, L Valdez, A Flores, and Darren Shaw. 1998. “Development of Immunity to Mecistocirrus Digitatus (Nematoda: Trichostrongylidae) in Calves.” Parasitology 117 (1): 83–87.
Vancouver
1.
Van Aken D, Vercruysse J, Dargantes A, Valdez L, Flores A, Shaw D. Development of immunity to Mecistocirrus digitatus (Nematoda: Trichostrongylidae) in calves. PARASITOLOGY. 1998;117(1):83–7.
IEEE
[1]
D. Van Aken, J. Vercruysse, A. Dargantes, L. Valdez, A. Flores, and D. Shaw, “Development of immunity to Mecistocirrus digitatus (Nematoda: Trichostrongylidae) in calves,” PARASITOLOGY, vol. 117, no. 1, pp. 83–87, 1998.
@article{179148,
  abstract     = {The importance of the third (L-3), fourth (L-4) and adult stages of Mecistocirrus digitatuts in inducing resistance to reinfection was examined. Three groups of 5 calves (A, B, C) were immunized for 2 consecutive days with a daily dose of 20 000 M. digitatus infectious larvae. Group A was treated with ivermectin 7 days post-infection (exposed to L-3), group B was treated after 26 days (exposed to L-3 and L-4) and group C after 60 days (exposed to L-3, L-4 and adults). Thirty days posttreatment, animals were challenged with 30 000 M. digitatus L-3. Five previously uninfected control animals (group D) also received 30 000 L-3. All animals were necropsied 75 days post-challenge. Increases in exposure to the immunizing infection resulted in significant increases in the pre-patent period post-challenge; 54 days in the controls, compared with 63, 70 and 72 days for groups A, B and C, respectively. Only adult worms were recovered at necropsy, and the mean number of worms significantly increased with increasing exposure to the immunizing infection: 355 in the controls, compared to 481, 937 and 1174 in groups A, B and C, respectively. No significant changes in worm length were observed. Infection with M. digitatus significantly affects a subsequent challenge infection - stimulation of the immune system by exposure to L-3 extends the pre-patent period, and suppression by later stages (L-4, adult) leads to higher worm burdens.},
  author       = {Van Aken, Dirk and Vercruysse, Jozef and Dargantes, A and Valdez, L and Flores, A and Shaw, Darren},
  issn         = {0031-1820},
  journal      = {PARASITOLOGY},
  keywords     = {Mecistocirrus digitatus,cattle,Nematoda,abbreviated infections,immunity,ivermectin,third-stage larvae (L-3),fourth-stage larvae (L-4),INFECTIONS,CATTLE},
  language     = {eng},
  number       = {1},
  pages        = {83--87},
  title        = {Development of immunity to Mecistocirrus digitatus (Nematoda: Trichostrongylidae) in calves},
  volume       = {117},
  year         = {1998},
}

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