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Effects of endobronchial challenge with Actinobacillus pleuropneumoniae serotype 9 of pigs vaccinated with inactivated vaccines containing the Apx toxins

Koen Chiers UGent, Ingrid Van Overbeke UGent, Piet De Laender, Richard Ducatelle UGent, S Carel and Freddy Haesebrouck UGent (1998) VETERINARY QUARTERLY. 20(2). p.65-69
abstract
The efficacy of two inactivated vaccines containing the Apx toxins of Actinobacillus pleuropneumoniae (Hemopig(TM), Biokema, Lausanne, Switzerland and Porcilis(TM) APP, Intervet, Boxmeer, the Netherlands) was determined. Ten pigs were vaccinated twice with Hemopig(TM) and eight pigs with Porcilis(TM) App. Ten control animals were injected twice with a saline solution. Three weeks after the second vaccination, all pigs were endobronchially inoculated with 10(5) colony-forming units (CFU) of an A. pleuropneumoniae serotype 9 strain. Increased respiratory rate and/or fever were observed in all vaccinated and control pigs after challenge. One pig of the Hemopig(TM) group and of the Porcilis(TM) App group died, whereas all pigs of the control group survived the challenge. Surviving pigs were killed at 7 days after challenge. The mean percentage of affected lung tissue was 34% in the control group, 16% in the Hemopig(TM) group, and 17% in the Porcilis(TM) App group. A. pleuropneumoniae was isolated from the lungs of all 10 control animals, from 7 of the 10 animals vaccinated with Hemopig(TM) and from 5 of the 8 animals vaccinated,vith Porcilis(TM) App. The mean bacterial titres of the caudal lung lobes were 1.4x10(6) CFU/g in the control group, 1.7x10(3) CFU/g in the Hemopig(TM) group, and 4.8x10(3) CFU/g in the Porcilis(TM) App group. In both vaccinated groups the mean number of days with dyspnoea, the mean number of days with fever, the mean percentage of affected lung tissue, and the mean bacterial titre in the caudal lung lobes were significantly lower than in the control group, Significant differences between the two vaccinated groups were not observed. It was concluded that both vaccines induced partial protection.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
CYTOLYSINS, STRAINS, RTX-TOXINS, PROTECTION
journal title
VETERINARY QUARTERLY
Vet. Q.
volume
20
issue
2
pages
65 - 69
Web of Science type
Article
Web of Science id
000073026600006
ISSN
0165-2176
language
English
UGent publication?
yes
classification
A1
id
177575
handle
http://hdl.handle.net/1854/LU-177575
date created
2004-01-14 13:41:00
date last changed
2017-07-12 13:14:05
@article{177575,
  abstract     = {The efficacy of two inactivated vaccines containing the Apx toxins of Actinobacillus pleuropneumoniae (Hemopig(TM), Biokema, Lausanne, Switzerland and Porcilis(TM) APP, Intervet, Boxmeer, the Netherlands) was determined. Ten pigs were vaccinated twice with Hemopig(TM) and eight pigs with Porcilis(TM) App. Ten control animals were injected twice with a saline solution. Three weeks after the second vaccination, all pigs were endobronchially inoculated with 10(5) colony-forming units (CFU) of an A. pleuropneumoniae serotype 9 strain. Increased respiratory rate and/or fever were observed in all vaccinated and control pigs after challenge. One pig of the Hemopig(TM) group and of the Porcilis(TM) App group died, whereas all pigs of the control group survived the challenge. Surviving pigs were killed at 7 days after challenge. The mean percentage of affected lung tissue was 34\% in the control group, 16\% in the Hemopig(TM) group, and 17\% in the Porcilis(TM) App group. A. pleuropneumoniae was isolated from the lungs of all 10 control animals, from 7 of the 10 animals vaccinated with Hemopig(TM) and from 5 of the 8 animals vaccinated,vith Porcilis(TM) App. The mean bacterial titres of the caudal lung lobes were 1.4x10(6) CFU/g in the control group, 1.7x10(3) CFU/g in the Hemopig(TM) group, and 4.8x10(3) CFU/g in the Porcilis(TM) App group. In both vaccinated groups the mean number of days with dyspnoea, the mean number of days with fever, the mean percentage of affected lung tissue, and the mean bacterial titre in the caudal lung lobes were significantly lower than in the control group, Significant differences between the two vaccinated groups were not observed. It was concluded that both vaccines induced partial protection.},
  author       = {Chiers, Koen and Van Overbeke, Ingrid and De Laender, Piet and Ducatelle, Richard and Carel, S and Haesebrouck, Freddy},
  issn         = {0165-2176},
  journal      = {VETERINARY QUARTERLY},
  keyword      = {CYTOLYSINS,STRAINS,RTX-TOXINS,PROTECTION},
  language     = {eng},
  number       = {2},
  pages        = {65--69},
  title        = {Effects of endobronchial challenge with Actinobacillus pleuropneumoniae serotype 9 of pigs vaccinated with inactivated vaccines containing the Apx toxins},
  volume       = {20},
  year         = {1998},
}

Chicago
Chiers, Koen, Ingrid Van Overbeke, Piet De Laender, Richard Ducatelle, S Carel, and Freddy Haesebrouck. 1998. “Effects of Endobronchial Challenge with Actinobacillus Pleuropneumoniae Serotype 9 of Pigs Vaccinated with Inactivated Vaccines Containing the Apx Toxins.” Veterinary Quarterly 20 (2): 65–69.
APA
Chiers, K., Van Overbeke, I., De Laender, P., Ducatelle, R., Carel, S., & Haesebrouck, F. (1998). Effects of endobronchial challenge with Actinobacillus pleuropneumoniae serotype 9 of pigs vaccinated with inactivated vaccines containing the Apx toxins. VETERINARY QUARTERLY, 20(2), 65–69.
Vancouver
1.
Chiers K, Van Overbeke I, De Laender P, Ducatelle R, Carel S, Haesebrouck F. Effects of endobronchial challenge with Actinobacillus pleuropneumoniae serotype 9 of pigs vaccinated with inactivated vaccines containing the Apx toxins. VETERINARY QUARTERLY. 1998;20(2):65–9.
MLA
Chiers, Koen, Ingrid Van Overbeke, Piet De Laender, et al. “Effects of Endobronchial Challenge with Actinobacillus Pleuropneumoniae Serotype 9 of Pigs Vaccinated with Inactivated Vaccines Containing the Apx Toxins.” VETERINARY QUARTERLY 20.2 (1998): 65–69. Print.