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Electrocardiographic and morphometric features in patients with ventricular tachycardia of right ventricular origin

J Kazmierczak, Johan De Sutter UGent, René Tavernier UGent, Claude Cuvelier, D Dimmer and Luc Jordaens UGent (1998) HEART. 79(4). p.388-393
abstract
Objective: To study differences between repetitive monomorphic ventricular tachycardia (RMVT) of right ventricular origin, and ventricular tachycardia in arrhythmogenic right ventricular dysplasia (ARVD). Patients: Consecutive groups with RMVT (n = 15) or ARVD (n = 12), comparable for age and function. Methods: Analysis of baseline, tachycardia, and signal averaged ECGs, clinical data, and right endomyocardial biopsies. Pathological findings were related to regional depolarisation (QRS width) and repolarisation (QT interval, QT dispersion). Results: There was no difference in age, ejection fraction, QRS width in leads I, V1, and V6, and QT indices. During ventricular tachycardia, more patients with ARVD had a QS wave in V1 (P < 0.05). There were significant differences for unfiltered QRS, low amplitude signal duration, and the root mean square voltage content. In the absence of bundle branch block, differences became nonsignificant for unfiltered and filtered QRS duration. Mean (SD) percentage of biopsy surface differed between RMVT and ARVD: normal myocytes (74(3.4)% v 64.5(9.3)%; p < 0.05); fibrosis (3(1.7)% v 8.9(5.2)%; p < 0.05). When all patients were included, there were significant correlations between fibrosis and age (r = 0.6761), and fibrosis and QRS width (r = 0.5524 for lead I; r = 0.5254 for lead V1; and r = 0.6017 for lead V6). Conclusions: The ECG during tachycardia and signal averaging are helpful in discriminating between ARVD and RMVT patients. There are differences in the proportions of normal myocytes and proportions of normal myocytes and fibrosis. The QRS duration is correlated with the amount of fibrous tissue in patients with ventricular tachycardia of right ventricular origin.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
electrocardiography, arrhythmogenic right ventricular dysplasia, endomyocardial biopsy, ventricular arrhythmias, ENDOMYOCARDIAL BIOPSY, DYSPLASIA, CARDIOMYOPATHY, ARRHYTHMIAS, QRS, STIMULATION, YOUNG
journal title
HEART
Heart
volume
79
issue
4
pages
388 - 393
Web of Science type
Article
Web of Science id
000073097600017
ISSN
1355-6037
language
English
UGent publication?
yes
classification
A1
id
177494
handle
http://hdl.handle.net/1854/LU-177494
date created
2004-01-14 13:41:00
date last changed
2016-12-19 15:38:06
@article{177494,
  abstract     = {Objective: To study differences between repetitive monomorphic ventricular tachycardia (RMVT) of right ventricular origin, and ventricular tachycardia in arrhythmogenic right ventricular dysplasia (ARVD). 
Patients: Consecutive groups with RMVT (n = 15) or ARVD (n = 12), comparable for age and function. 
Methods: Analysis of baseline, tachycardia, and signal averaged ECGs, clinical data, and right endomyocardial biopsies. Pathological findings were related to regional depolarisation (QRS width) and repolarisation (QT interval, QT dispersion). 
Results: There was no difference in age, ejection fraction, QRS width in leads I, V1, and V6, and QT indices. During ventricular tachycardia, more patients with ARVD had a QS wave in V1 (P {\textlangle} 0.05). There were significant differences for unfiltered QRS, low amplitude signal duration, and the root mean square voltage content. In the absence of bundle branch block, differences became nonsignificant for unfiltered and filtered QRS duration. Mean (SD) percentage of biopsy surface differed between RMVT and ARVD: normal myocytes (74(3.4)\% v 64.5(9.3)\%; p {\textlangle} 0.05); fibrosis (3(1.7)\% v 8.9(5.2)\%; p {\textlangle} 0.05). When all patients were included, there were significant correlations between fibrosis and age (r = 0.6761), and fibrosis and QRS width (r = 0.5524 for lead I; r = 0.5254 for lead V1; and r = 0.6017 for lead V6). 
Conclusions: The ECG during tachycardia and signal averaging are helpful in discriminating between ARVD and RMVT patients. There are differences in the proportions of normal myocytes and proportions of normal myocytes and fibrosis. The QRS duration is correlated with the amount of fibrous tissue in patients with ventricular tachycardia of right ventricular origin.},
  author       = {Kazmierczak, J and De Sutter, Johan and Tavernier, Ren{\'e} and Cuvelier, Claude and Dimmer, D and Jordaens, Luc},
  issn         = {1355-6037},
  journal      = {HEART},
  keyword      = {electrocardiography,arrhythmogenic right ventricular dysplasia,endomyocardial biopsy,ventricular arrhythmias,ENDOMYOCARDIAL BIOPSY,DYSPLASIA,CARDIOMYOPATHY,ARRHYTHMIAS,QRS,STIMULATION,YOUNG},
  language     = {eng},
  number       = {4},
  pages        = {388--393},
  title        = {Electrocardiographic and morphometric features in patients with ventricular tachycardia of right ventricular origin},
  volume       = {79},
  year         = {1998},
}

Chicago
Kazmierczak, J, Johan De Sutter, René Tavernier, Claude Cuvelier, D Dimmer, and Luc Jordaens. 1998. “Electrocardiographic and Morphometric Features in Patients with Ventricular Tachycardia of Right Ventricular Origin.” Heart 79 (4): 388–393.
APA
Kazmierczak, J., De Sutter, J., Tavernier, R., Cuvelier, C., Dimmer, D., & Jordaens, L. (1998). Electrocardiographic and morphometric features in patients with ventricular tachycardia of right ventricular origin. HEART, 79(4), 388–393.
Vancouver
1.
Kazmierczak J, De Sutter J, Tavernier R, Cuvelier C, Dimmer D, Jordaens L. Electrocardiographic and morphometric features in patients with ventricular tachycardia of right ventricular origin. HEART. 1998;79(4):388–93.
MLA
Kazmierczak, J, Johan De Sutter, René Tavernier, et al. “Electrocardiographic and Morphometric Features in Patients with Ventricular Tachycardia of Right Ventricular Origin.” HEART 79.4 (1998): 388–393. Print.