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Antibiotics commonly used to treat mastitis and respiratory burst of bovine polymorphonuclear leukocytes.

Dagmar Hoeben, Christian Burvenich UGent and Roger Heyneman (1998) JOURNAL OF DAIRY SCIENCE. 81(2). p.403-410
abstract
The in vitro effects of six doses (2 x 10(-3) to 2 x 10(-8) M) of antimicrobial drugs that are frequently used in udder infusions on the capacity of bovine blood polymorphonuclear neutrophilic leukocytes to generate reactive oxygen species were studied by the measurement of luminol-dependent chemiluminescence after stimulation with phorbol 12-myristate 13-acetate. All drugs, except cloxacillin, significantly decreased chemiluminescence at the highest dose. Doxycyline induced the most severe inhibition, followed by neomycin and dihydrostreptomycin. The effect of ampicillin was due to the scavenging of reactive oxygen species and interactions with luminol. The inhibition observed with oleandomycin, neomycin, lincomycin, and dihydrostreptomycin was not due to direct effects on the production of oxidative metabolites but rather to interference with other components involved in the production of light, such as interference with the interaction between luminol and the myeloperoxidase-H2O2-halide system. The deleterious effects of doxycycline can be explained by several factors: decreased production of superoxide, yellow color, the scavenging of reactive oxygen species, and Ca2+ chelating effect. In conclusion, the results of this study show that antibiotics may affect neutrophil function at concentrations that are reached in the mammary gland after local and repeated administration.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
PERIOD, MILK, GRANULOCYTES, COWS, PHAGOCYTOSIS, antibiotics, respiratory burst, polymorphonuclear neutrophilic leukocytes, ESCHERICHIA-COLI MASTITIS, ANTI-MICROBIAL AGENTS, CHEMI-LUMINESCENCE, ANTIMICROBIAL AGENTS, NEUTROPHIL FUNCTIONS
journal title
JOURNAL OF DAIRY SCIENCE
J. Dairy Sci.
volume
81
issue
2
pages
403-410 pages
Web of Science type
Article
Web of Science id
000072883700012
ISSN
0022-0302
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
177420
handle
http://hdl.handle.net/1854/LU-177420
alternative location
http://jds.fass.org/cgi/reprint/81/2/403
date created
2004-01-14 13:41:00
date last changed
2016-12-19 15:38:06
@article{177420,
  abstract     = {The in vitro effects of six doses (2 x 10(-3) to 2 x 10(-8) M) of antimicrobial drugs that are frequently used in udder infusions on the capacity of bovine blood polymorphonuclear neutrophilic leukocytes to generate reactive oxygen species were studied by the measurement of luminol-dependent chemiluminescence after stimulation with phorbol 12-myristate 13-acetate. All drugs, except cloxacillin, significantly decreased chemiluminescence at the highest dose. Doxycyline induced the most severe inhibition, followed by neomycin and dihydrostreptomycin. The effect of ampicillin was due to the scavenging of reactive oxygen species and interactions with luminol. The inhibition observed with oleandomycin, neomycin, lincomycin, and dihydrostreptomycin was not due to direct effects on the production of oxidative metabolites but rather to interference with other components involved in the production of light, such as interference with the interaction between luminol and the myeloperoxidase-H2O2-halide system. The deleterious effects of doxycycline can be explained by several factors: decreased production of superoxide, yellow color, the scavenging of reactive oxygen species, and Ca2+ chelating effect. In conclusion, the results of this study show that antibiotics may affect neutrophil function at concentrations that are reached in the mammary gland after local and repeated administration.},
  author       = {Hoeben, Dagmar and Burvenich, Christian and Heyneman, Roger},
  issn         = {0022-0302},
  journal      = {JOURNAL OF DAIRY SCIENCE},
  keyword      = {PERIOD,MILK,GRANULOCYTES,COWS,PHAGOCYTOSIS,antibiotics,respiratory burst,polymorphonuclear neutrophilic leukocytes,ESCHERICHIA-COLI MASTITIS,ANTI-MICROBIAL AGENTS,CHEMI-LUMINESCENCE,ANTIMICROBIAL AGENTS,NEUTROPHIL FUNCTIONS},
  language     = {eng},
  number       = {2},
  pages        = {403--410},
  title        = {Antibiotics commonly used to treat mastitis and respiratory burst of bovine polymorphonuclear leukocytes.},
  url          = {http://jds.fass.org/cgi/reprint/81/2/403},
  volume       = {81},
  year         = {1998},
}

Chicago
Hoeben, Dagmar, Christian Burvenich, and Roger Heyneman. 1998. “Antibiotics Commonly Used to Treat Mastitis and Respiratory Burst of Bovine Polymorphonuclear Leukocytes.” Journal of Dairy Science 81 (2): 403–410.
APA
Hoeben, Dagmar, Burvenich, C., & Heyneman, R. (1998). Antibiotics commonly used to treat mastitis and respiratory burst of bovine polymorphonuclear leukocytes. JOURNAL OF DAIRY SCIENCE, 81(2), 403–410.
Vancouver
1.
Hoeben D, Burvenich C, Heyneman R. Antibiotics commonly used to treat mastitis and respiratory burst of bovine polymorphonuclear leukocytes. JOURNAL OF DAIRY SCIENCE. 1998;81(2):403–10.
MLA
Hoeben, Dagmar, Christian Burvenich, and Roger Heyneman. “Antibiotics Commonly Used to Treat Mastitis and Respiratory Burst of Bovine Polymorphonuclear Leukocytes.” JOURNAL OF DAIRY SCIENCE 81.2 (1998): 403–410. Print.