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Characteristic pattern of chromosomal gains and losses in Merkel cell carcinoma detected by comparative genomic hybridization

Mireille Van Gele UGent, Franki Speleman UGent, Jo Vandesompele UGent, Nadine Van Roy UGent and JH Leonard (1998) CANCER RESEARCH. 58(7). p.1503-1508
abstract
Merkel cell carcinoma or small cell carcinoma of the skin is a rare skin cancer seen in increasing numbers in Queensland, Australia. In its clinical course and histopathology, it resembles small cell lung carcinoma (SCLC), Little is known of the genetic basis of this disease except for a number of cytogenetic studies and three loss of heterozygosity studies. Therefore, comparative genomic hybridization was performed to determine the characteristic DNA gains and losses that occur in this tumor, Comparative genomic hybridization analysis of 34 specimens from 24 patients revealed a pattern of gains and losses that closely resembles that seen in SCLC. Overall frequent loss was seen for chromosomes 3p (46%), 5q (21%), 8p (21%), 10 (33%), 11q (17%), 13q (33%), and 17p (25%), Significant gains were seen for chromosomes 1 (63%), 3q (33%), 5p (38%), 8q (38%), 19 (63%), and X (41%), with smaller numbers having gains for chromosomes 6, 7, 20, and 21. In contrast to SCLC, amplification in Merkel cell carcinoma is a rare event.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
IN-SITU HYBRIDIZATION, HUMAN PROSTATE-CANCER, DNA COPY NUMBER, ALLELIC LOSS, SHORT ARM, SKIN CARCINOMA, DELETION, TUMOR, IDENTIFICATION, HETEROZYGOSITY
journal title
CANCER RESEARCH
Cancer Res.
volume
58
issue
7
pages
1503 - 1508
Web of Science type
Article
Web of Science id
000072780200034
ISSN
0008-5472
language
English
UGent publication?
yes
classification
A1
id
177203
handle
http://hdl.handle.net/1854/LU-177203
date created
2004-01-14 13:41:00
date last changed
2017-04-10 07:55:18
@article{177203,
  abstract     = {Merkel cell carcinoma or small cell carcinoma of the skin is a rare skin cancer seen in increasing numbers in Queensland, Australia. In its clinical course and histopathology, it resembles small cell lung carcinoma (SCLC), Little is known of the genetic basis of this disease except for a number of cytogenetic studies and three loss of heterozygosity studies. Therefore, comparative genomic hybridization was performed to determine the characteristic DNA gains and losses that occur in this tumor, Comparative genomic hybridization analysis of 34 specimens from 24 patients revealed a pattern of gains and losses that closely resembles that seen in SCLC. Overall frequent loss was seen for chromosomes 3p (46\%), 5q (21\%), 8p (21\%), 10 (33\%), 11q (17\%), 13q (33\%), and 17p (25\%), Significant gains were seen for chromosomes 1 (63\%), 3q (33\%), 5p (38\%), 8q (38\%), 19 (63\%), and X (41\%), with smaller numbers having gains for chromosomes 6, 7, 20, and 21. In contrast to SCLC, amplification in Merkel cell carcinoma is a rare event.},
  author       = {Van Gele, Mireille and Speleman, Franki and Vandesompele, Jo and Van Roy, Nadine and Leonard, JH},
  issn         = {0008-5472},
  journal      = {CANCER RESEARCH},
  keyword      = {IN-SITU HYBRIDIZATION,HUMAN PROSTATE-CANCER,DNA COPY NUMBER,ALLELIC LOSS,SHORT ARM,SKIN CARCINOMA,DELETION,TUMOR,IDENTIFICATION,HETEROZYGOSITY},
  language     = {eng},
  number       = {7},
  pages        = {1503--1508},
  title        = {Characteristic pattern of chromosomal gains and losses in Merkel cell carcinoma detected by comparative genomic hybridization},
  volume       = {58},
  year         = {1998},
}

Chicago
Van Gele, Mireille, Franki Speleman, Jo Vandesompele, Nadine Van Roy, and JH Leonard. 1998. “Characteristic Pattern of Chromosomal Gains and Losses in Merkel Cell Carcinoma Detected by Comparative Genomic Hybridization.” Cancer Research 58 (7): 1503–1508.
APA
Van Gele, M., Speleman, F., Vandesompele, J., Van Roy, N., & Leonard, J. (1998). Characteristic pattern of chromosomal gains and losses in Merkel cell carcinoma detected by comparative genomic hybridization. CANCER RESEARCH, 58(7), 1503–1508.
Vancouver
1.
Van Gele M, Speleman F, Vandesompele J, Van Roy N, Leonard J. Characteristic pattern of chromosomal gains and losses in Merkel cell carcinoma detected by comparative genomic hybridization. CANCER RESEARCH. 1998;58(7):1503–8.
MLA
Van Gele, Mireille, Franki Speleman, Jo Vandesompele, et al. “Characteristic Pattern of Chromosomal Gains and Losses in Merkel Cell Carcinoma Detected by Comparative Genomic Hybridization.” CANCER RESEARCH 58.7 (1998): 1503–1508. Print.