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Characteristic pattern of chromosomal gains and losses in Merkel cell carcinoma detected by comparative genomic hybridization

Mireille Van Gele (UGent) , Franki Speleman (UGent) , Jo Vandesompele (UGent) , Nadine Van Roy (UGent) and JH Leonard
(1998) CANCER RESEARCH. 58(7). p.1503-1508
Author
Organization
Abstract
Merkel cell carcinoma or small cell carcinoma of the skin is a rare skin cancer seen in increasing numbers in Queensland, Australia. In its clinical course and histopathology, it resembles small cell lung carcinoma (SCLC), Little is known of the genetic basis of this disease except for a number of cytogenetic studies and three loss of heterozygosity studies. Therefore, comparative genomic hybridization was performed to determine the characteristic DNA gains and losses that occur in this tumor, Comparative genomic hybridization analysis of 34 specimens from 24 patients revealed a pattern of gains and losses that closely resembles that seen in SCLC. Overall frequent loss was seen for chromosomes 3p (46%), 5q (21%), 8p (21%), 10 (33%), 11q (17%), 13q (33%), and 17p (25%), Significant gains were seen for chromosomes 1 (63%), 3q (33%), 5p (38%), 8q (38%), 19 (63%), and X (41%), with smaller numbers having gains for chromosomes 6, 7, 20, and 21. In contrast to SCLC, amplification in Merkel cell carcinoma is a rare event.
Keywords
IN-SITU HYBRIDIZATION, HUMAN PROSTATE-CANCER, DNA COPY NUMBER, ALLELIC LOSS, SHORT ARM, SKIN CARCINOMA, DELETION, TUMOR, IDENTIFICATION, HETEROZYGOSITY

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Chicago
Van Gele, Mireille, Franki Speleman, Jo Vandesompele, Nadine Van Roy, and JH Leonard. 1998. “Characteristic Pattern of Chromosomal Gains and Losses in Merkel Cell Carcinoma Detected by Comparative Genomic Hybridization.” Cancer Research 58 (7): 1503–1508.
APA
Van Gele, M., Speleman, F., Vandesompele, J., Van Roy, N., & Leonard, J. (1998). Characteristic pattern of chromosomal gains and losses in Merkel cell carcinoma detected by comparative genomic hybridization. CANCER RESEARCH, 58(7), 1503–1508.
Vancouver
1.
Van Gele M, Speleman F, Vandesompele J, Van Roy N, Leonard J. Characteristic pattern of chromosomal gains and losses in Merkel cell carcinoma detected by comparative genomic hybridization. CANCER RESEARCH. 1998;58(7):1503–8.
MLA
Van Gele, Mireille, Franki Speleman, Jo Vandesompele, et al. “Characteristic Pattern of Chromosomal Gains and Losses in Merkel Cell Carcinoma Detected by Comparative Genomic Hybridization.” CANCER RESEARCH 58.7 (1998): 1503–1508. Print.
@article{177203,
  abstract     = {Merkel cell carcinoma or small cell carcinoma of the skin is a rare skin cancer seen in increasing numbers in Queensland, Australia. In its clinical course and histopathology, it resembles small cell lung carcinoma (SCLC), Little is known of the genetic basis of this disease except for a number of cytogenetic studies and three loss of heterozygosity studies. Therefore, comparative genomic hybridization was performed to determine the characteristic DNA gains and losses that occur in this tumor, Comparative genomic hybridization analysis of 34 specimens from 24 patients revealed a pattern of gains and losses that closely resembles that seen in SCLC. Overall frequent loss was seen for chromosomes 3p (46\%), 5q (21\%), 8p (21\%), 10 (33\%), 11q (17\%), 13q (33\%), and 17p (25\%), Significant gains were seen for chromosomes 1 (63\%), 3q (33\%), 5p (38\%), 8q (38\%), 19 (63\%), and X (41\%), with smaller numbers having gains for chromosomes 6, 7, 20, and 21. In contrast to SCLC, amplification in Merkel cell carcinoma is a rare event.},
  author       = {Van Gele, Mireille and Speleman, Franki and Vandesompele, Jo and Van Roy, Nadine and Leonard, JH},
  issn         = {0008-5472},
  journal      = {CANCER RESEARCH},
  keyword      = {IN-SITU HYBRIDIZATION,HUMAN PROSTATE-CANCER,DNA COPY NUMBER,ALLELIC LOSS,SHORT ARM,SKIN CARCINOMA,DELETION,TUMOR,IDENTIFICATION,HETEROZYGOSITY},
  language     = {eng},
  number       = {7},
  pages        = {1503--1508},
  title        = {Characteristic pattern of chromosomal gains and losses in Merkel cell carcinoma detected by comparative genomic hybridization},
  volume       = {58},
  year         = {1998},
}

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