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Effect of inhaled nitric oxide on the hypoxic pulmonary vasoconstrictor response in anaesthetised calves.

(1997) RESEARCH IN VETERINARY SCIENCE. 63(3). p.193-197
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Abstract
The effect of inhaling nitric oxide in the hypoxic pulmonary vascular response was measured in five calves anaesthetised with a combination of guaiacol, ketamine and xylazine. Alveolar hypoxia was induced by means of the inhalation of a gas mixture with an inspiratory oxygen fraction of 14-18 per cent. This alveolar hypoxia resulted in a pronounced pulmonary hypertension (mean pulmonary artery pressure in hypoxic animals : 30.2 mmHg). Inhalation of 20 and 40 ppm of nitric oxide significantly attenuated the hypoxia induced pulmonary hypertension. The effect ceased once nitric oxide administration was stopped. A concentration of 40 ppm of nitric oxide fully abolished the hypoxia induced pulmonary hypertension (mean pulmonary artery pressure during inhalation of 40 ppm nitric oxide : 22.8 mmHg). Inhalation of nitric oxide had no effect on systemic arterial blood pressure nor on systemic vascular resistance. It was concluded that inhalation of 20 or 40 ppm of nitric oxide prevented a selective pulmonary vasoconstriction during alveolar hypoxia in calves, which may be helpful in the treatment of acute respiratory disorders in calves.

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Citation

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MLA
Sustronck, Bart, Gunther van Loon, Piet Deprez, et al. “Effect of Inhaled Nitric Oxide on the Hypoxic Pulmonary Vasoconstrictor Response in Anaesthetised Calves.” RESEARCH IN VETERINARY SCIENCE 63.3 (1997): 193–197. Print.
APA
Sustronck, B., van Loon, G., Deprez, P., Muylle, E., Gasthuys, F., & FOUBERT, L. (1997). Effect of inhaled nitric oxide on the hypoxic pulmonary vasoconstrictor response in anaesthetised calves. RESEARCH IN VETERINARY SCIENCE, 63(3), 193–197.
Chicago author-date
Sustronck, Bart, Gunther van Loon, Piet Deprez, Etienne Muylle, Frank Gasthuys, and L FOUBERT. 1997. “Effect of Inhaled Nitric Oxide on the Hypoxic Pulmonary Vasoconstrictor Response in Anaesthetised Calves.” Research in Veterinary Science 63 (3): 193–197.
Chicago author-date (all authors)
Sustronck, Bart, Gunther van Loon, Piet Deprez, Etienne Muylle, Frank Gasthuys, and L FOUBERT. 1997. “Effect of Inhaled Nitric Oxide on the Hypoxic Pulmonary Vasoconstrictor Response in Anaesthetised Calves.” Research in Veterinary Science 63 (3): 193–197.
Vancouver
1.
Sustronck B, van Loon G, Deprez P, Muylle E, Gasthuys F, FOUBERT L. Effect of inhaled nitric oxide on the hypoxic pulmonary vasoconstrictor response in anaesthetised calves. RESEARCH IN VETERINARY SCIENCE. 1997;63(3):193–7.
IEEE
[1]
B. Sustronck, G. van Loon, P. Deprez, E. Muylle, F. Gasthuys, and L. FOUBERT, “Effect of inhaled nitric oxide on the hypoxic pulmonary vasoconstrictor response in anaesthetised calves.,” RESEARCH IN VETERINARY SCIENCE, vol. 63, no. 3, pp. 193–197, 1997.
@article{176454,
  abstract     = {The effect of inhaling nitric oxide in the hypoxic pulmonary vascular response was measured in five calves anaesthetised with a combination of guaiacol, ketamine and xylazine. Alveolar hypoxia was induced by means of the inhalation of a gas mixture with an inspiratory oxygen fraction of 14-18 per cent. This alveolar hypoxia resulted in a pronounced pulmonary hypertension (mean pulmonary artery pressure in hypoxic animals : 30.2 mmHg). Inhalation of 20 and 40 ppm of nitric oxide significantly attenuated the hypoxia induced pulmonary hypertension. The effect ceased once nitric oxide administration was stopped. A concentration of 40 ppm of nitric oxide fully abolished the hypoxia induced pulmonary hypertension (mean pulmonary artery pressure during inhalation of 40 ppm nitric oxide : 22.8 mmHg). Inhalation of nitric oxide had no effect on systemic arterial blood pressure nor on systemic vascular resistance. It was concluded that inhalation of 20 or 40 ppm of nitric oxide prevented a selective pulmonary vasoconstriction during alveolar hypoxia in calves, which may be helpful in the treatment of acute respiratory disorders in calves.},
  author       = {Sustronck, Bart and van Loon, Gunther and Deprez, Piet and Muylle, Etienne and Gasthuys, Frank and FOUBERT, L},
  issn         = {0034-5288},
  journal      = {RESEARCH IN VETERINARY SCIENCE},
  language     = {eng},
  number       = {3},
  pages        = {193--197},
  title        = {Effect of inhaled nitric oxide on the hypoxic pulmonary vasoconstrictor response in anaesthetised calves.},
  volume       = {63},
  year         = {1997},
}

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