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Single-voxel proton MR spectroscopy and positron emission tomography for lateralization of refractory temporal lobe epilepsy

Eric Achten UGent, Patrick Santens UGent, Paul Boon UGent, Danny De Coo, Tom Van de Kerckhove, Jacques De Reuck UGent, Jacques Caemaert UGent and Marc Kunnen UGent (1998) AMERICAN JOURNAL OF NEURORADIOLOGY. 19(1). p.1-8
abstract
PURPOSE: We compared the metabolic information obtained from single-voxel proton MR spectroscopy and positron emission tomography (PET) in patients with temporal lobe epilepsy. METHODS: Twenty-nine patients,vith temporal lobe epilepsy were screened for metabolic abnormalities with both proton MR spectroscopy and PET. Lateralization with MR spectroscopy was possible by using NAA/(Cho+Cr) and an asymmetry index. Hypometabolism as determined by PET was classified as typical or complex. RESULTS: Twenty-four (96%) of 25 patients whose seizure onset could be lateralized to one temporal lobe showed ipsilateral lateralization with either MR spectroscopy or PET, whereas concordant lateralization with both techniques was possible only in 14 (56%) of the 25 patients. MR spectroscopy showed 42 abnormal temporal lobes whereas PET showed only 25 lobes with decreased metabolism. All temporal lobes with hypometabolism at PET also had a low NAA/(Cho+Cr). Five patients (20%) with negative PET studies had seizures lateralized correctly with MR spectroscopy. CONCLUSION: Proton MR spectroscopy is more sensitive in depicting metabolic abnormalities than is PET in patients with temporal lobe epilepsy. Patients with negative PET studies will benefit from MR spectroscopy for the purpose of lateralization
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
PRESURGICAL EVALUATION, MAGNETIC-RESONANCE SPECTROSCOPY, H-1-NMR SPECTROSCOPY, HYPOMETABOLISM, LOCALIZATION, SCLEROSIS, ASPARTATE, EXTRACTS, ORIGIN, INVIVO
journal title
AMERICAN JOURNAL OF NEURORADIOLOGY
Am. J. Neuroradiol.
volume
19
issue
1
pages
1-8 pages
Web of Science type
Article
Web of Science id
000071026700009
ISSN
0195-6108
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
175840
handle
http://hdl.handle.net/1854/LU-175840
alternative location
http://www.ajnr.org/cgi/content/abstract/19/1/1
date created
2004-01-14 13:40:00
date last changed
2010-04-27 14:06:16
@article{175840,
  abstract     = {PURPOSE: We compared the metabolic information obtained from single-voxel proton MR spectroscopy and positron emission tomography (PET) in patients with temporal lobe epilepsy.
METHODS: Twenty-nine patients,vith temporal lobe epilepsy were screened for metabolic abnormalities with both proton MR spectroscopy and PET. Lateralization with MR spectroscopy was possible by using NAA/(Cho+Cr) and an asymmetry index. Hypometabolism as determined by PET was classified as typical or complex.
RESULTS: Twenty-four (96\%) of 25 patients whose seizure onset could be lateralized to one temporal lobe showed ipsilateral lateralization with either MR spectroscopy or PET, whereas concordant lateralization with both techniques was possible only in 14 (56\%) of the 25 patients. MR spectroscopy showed 42 abnormal temporal lobes whereas PET showed only 25 lobes with decreased metabolism. All temporal lobes with hypometabolism at PET also had a low NAA/(Cho+Cr). Five patients (20\%) with negative PET studies had seizures lateralized correctly with MR spectroscopy.
CONCLUSION: Proton MR spectroscopy is more sensitive in depicting metabolic abnormalities than is PET in patients with temporal lobe epilepsy. Patients with negative PET studies will benefit from MR spectroscopy for the purpose of lateralization},
  author       = {Achten, Eric and Santens, Patrick and Boon, Paul and De Coo, Danny and Van de Kerckhove, Tom and De Reuck, Jacques and Caemaert, Jacques and Kunnen, Marc},
  issn         = {0195-6108},
  journal      = {AMERICAN JOURNAL OF NEURORADIOLOGY},
  keyword      = {PRESURGICAL EVALUATION,MAGNETIC-RESONANCE SPECTROSCOPY,H-1-NMR SPECTROSCOPY,HYPOMETABOLISM,LOCALIZATION,SCLEROSIS,ASPARTATE,EXTRACTS,ORIGIN,INVIVO},
  language     = {eng},
  number       = {1},
  pages        = {1--8},
  title        = {Single-voxel proton MR spectroscopy and positron emission tomography for lateralization of refractory temporal lobe epilepsy},
  url          = {http://www.ajnr.org/cgi/content/abstract/19/1/1},
  volume       = {19},
  year         = {1998},
}

Chicago
Achten, Eric, Patrick Santens, Paul Boon, Danny De Coo, Tom Van de Kerckhove, Jacques De Reuck, Jacques Caemaert, and Marc Kunnen. 1998. “Single-voxel Proton MR Spectroscopy and Positron Emission Tomography for Lateralization of Refractory Temporal Lobe Epilepsy.” American Journal of Neuroradiology 19 (1): 1–8.
APA
Achten, E., Santens, P., Boon, P., De Coo, D., Van de Kerckhove, T., De Reuck, J., Caemaert, J., et al. (1998). Single-voxel proton MR spectroscopy and positron emission tomography for lateralization of refractory temporal lobe epilepsy. AMERICAN JOURNAL OF NEURORADIOLOGY, 19(1), 1–8.
Vancouver
1.
Achten E, Santens P, Boon P, De Coo D, Van de Kerckhove T, De Reuck J, et al. Single-voxel proton MR spectroscopy and positron emission tomography for lateralization of refractory temporal lobe epilepsy. AMERICAN JOURNAL OF NEURORADIOLOGY. 1998;19(1):1–8.
MLA
Achten, Eric, Patrick Santens, Paul Boon, et al. “Single-voxel Proton MR Spectroscopy and Positron Emission Tomography for Lateralization of Refractory Temporal Lobe Epilepsy.” AMERICAN JOURNAL OF NEURORADIOLOGY 19.1 (1998): 1–8. Print.