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Larval migration inhibition activity in abomasal mucus and serum from calves infected with Ostertagia ostertagi

(1999) RESEARCH IN VETERINARY SCIENCE. 66(3). p.253-257
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Abstract
The present study investigated whether abomasal mucus from calves naturally infected with gastrointestinal nematodes possessed larval migration inhibition (LMI) activity in vitro, and whether LMI activity was greater in mucus from previously immunised animals, compared to primary infected and uninfected calves. LMI activity was also assessed in serum from calves during both natural and artificial Ostertagia ostertagi infections, in an attempt to monitor the development of acquired immunity. Both abomasal mucus and serum exhibited larval paralysing activity. Although the LMI capacity of the abomasal mucus was very variable, the highest paralysing activity was consistently observed in mucus from previously immunised calves. LMI activity in serum increased significantly during both artificial and natural Ostertagia infections. After a challenge infection, sera from immunised animals showed a significantly higher LMI capacity, compared to previously uninfected calves. Moreover, serum LMI activity was significantly negatively correlated with Ostertagia worm counts after the challenge infection. The present results suggest that LMI activity in serum and/or abomasal mucus reflects a protective immune response against O. ostertagi in the abomasal mucosa.
Keywords
ACQUIRED-RESISTANCE, SEASON GRAZING CALVES, GASTROINTESTINAL NEMATODES, TRICHOSTRONGYLE INFECTIONS, IN-VITRO, SHEEP, CATTLE, CHEMOPROPHYLAXIS, SUBSTANCES, ANTHELMINTICS

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Chicago
Claerebout, Edwin, Joost Agneessens, Darren Shaw, and Jozef Vercruysse. 1999. “Larval Migration Inhibition Activity in Abomasal Mucus and Serum from Calves Infected with Ostertagia Ostertagi.” Research in Veterinary Science 66 (3): 253–257.
APA
Claerebout, Edwin, Agneessens, J., Shaw, D., & Vercruysse, J. (1999). Larval migration inhibition activity in abomasal mucus and serum from calves infected with Ostertagia ostertagi. RESEARCH IN VETERINARY SCIENCE, 66(3), 253–257.
Vancouver
1.
Claerebout E, Agneessens J, Shaw D, Vercruysse J. Larval migration inhibition activity in abomasal mucus and serum from calves infected with Ostertagia ostertagi. RESEARCH IN VETERINARY SCIENCE. 1999;66(3):253–7.
MLA
Claerebout, Edwin, Joost Agneessens, Darren Shaw, et al. “Larval Migration Inhibition Activity in Abomasal Mucus and Serum from Calves Infected with Ostertagia Ostertagi.” RESEARCH IN VETERINARY SCIENCE 66.3 (1999): 253–257. Print.
@article{174598,
  abstract     = {The present study investigated whether abomasal mucus from calves naturally infected with gastrointestinal nematodes possessed larval migration inhibition (LMI) activity in vitro, and whether LMI activity was greater in mucus from previously immunised animals, compared to primary infected and uninfected calves. LMI activity was also assessed in serum from calves during both natural and artificial Ostertagia ostertagi infections, in an attempt to monitor the development of acquired immunity. Both abomasal mucus and serum exhibited larval paralysing activity. Although the LMI capacity of the abomasal mucus was very variable, the highest paralysing activity was consistently observed in mucus from previously immunised calves. LMI activity in serum increased significantly during both artificial and natural Ostertagia infections. After a challenge infection, sera from immunised animals showed a significantly higher LMI capacity, compared to previously uninfected calves. Moreover, serum LMI activity was significantly negatively correlated with Ostertagia worm counts after the challenge infection. The present results suggest that LMI activity in serum and/or abomasal mucus reflects a protective immune response against O. ostertagi in the abomasal mucosa.},
  author       = {Claerebout, Edwin and Agneessens, Joost and Shaw, Darren and Vercruysse, Jozef},
  issn         = {0034-5288},
  journal      = {RESEARCH IN VETERINARY SCIENCE},
  language     = {eng},
  number       = {3},
  pages        = {253--257},
  title        = {Larval migration inhibition activity in abomasal mucus and serum from calves infected with Ostertagia ostertagi},
  url          = {http://dx.doi.org/10.1053/rvsc.1998.0281},
  volume       = {66},
  year         = {1999},
}

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