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Vagus nerve stimulation for refractory epilepsy

Paul Boon UGent, Kristl Vonck UGent, Tom Vandekerckhove UGent, Jacques De Reuck UGent and Luc Calliauw (2001) NEUROSURGERY QUARTERLY. 11(1). p.66-72
abstract
Left-sided vagus nerve stimulation (VNS) is a relatively new and efficacious neurophysiological treatment for patients with refractory epilepsy who were rejected for resective epilepsy surgery or who have had insufficient benefit from such a treatment, Animal experiments have shown that electrical stimulation of the vagus nerve san reduce the occurrence and duration of electrically and chemically induced seizures, The precise mechanism of action remains unclear. In 1988 the first vagus nerve stimulator was implanted in humans. Currently more than 7500 patients have been implanted world-wide, Randomized controlled clinical studies have shown a more than 50% reduction in seizure frequency in one third of the patients. Results on long-term treatment indicate that VNS remains effective over time and a trend towards improved seizure control with longer use of VNS was observed. VNS seems equally efficient in children. Hoarseness or voice change during stimulation are the most common side effects. VNS requires a substantial financial investment. Cost-efficacy studies have shown that these costs can easily be payed back by savings in epilepsy related direct medical costs in patients treated with VNS.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
refractory seizures, epilepsy, vagus nerve stimulation, epilepsy surgery, seizure frequency, efficacy, MEDICALLY INTRACTABLE SEIZURES, COST-BENEFIT, CHILDREN, HUMANS, TRIAL, BRAIN, INHIBITION, EFFICACY
journal title
NEUROSURGERY QUARTERLY
Neurosurg. Q.
volume
11
issue
1
pages
66 - 72
Web of Science type
Article
Web of Science id
000169545800007
JCR category
NEUROSCIENCES
JCR impact factor
0.217 (2001)
JCR rank
181/198 (2001)
JCR quartile
4 (2001)
ISSN
1050-6438
DOI
10.1097/00013414-200103000-00007
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
169097
handle
http://hdl.handle.net/1854/LU-169097
date created
2004-01-14 13:40:00
date last changed
2012-05-22 14:14:42
@article{169097,
  abstract     = {Left-sided vagus nerve stimulation (VNS) is a relatively new and efficacious neurophysiological treatment for patients with refractory epilepsy who were rejected for resective epilepsy surgery or who have had insufficient benefit from such a treatment, Animal experiments have shown that electrical stimulation of the vagus nerve san reduce the occurrence and duration of electrically and chemically induced seizures, The precise mechanism of action remains unclear. In 1988 the first vagus nerve stimulator was implanted in humans. Currently more than 7500 patients have been implanted world-wide, Randomized controlled clinical studies have shown a more than 50\% reduction in seizure frequency in one third of the patients. Results on long-term treatment indicate that VNS remains effective over time and a trend towards improved seizure control with longer use of VNS was observed. VNS seems equally efficient in children. Hoarseness or voice change during stimulation are the most common side effects. VNS requires a substantial financial investment. Cost-efficacy studies have shown that these costs can easily be payed back by savings in epilepsy related direct medical costs in patients treated with VNS.},
  author       = {Boon, Paul and Vonck, Kristl and Vandekerckhove, Tom and De Reuck, Jacques and Calliauw, Luc},
  issn         = {1050-6438},
  journal      = {NEUROSURGERY QUARTERLY},
  keyword      = {refractory seizures,epilepsy,vagus nerve stimulation,epilepsy surgery,seizure frequency,efficacy,MEDICALLY INTRACTABLE SEIZURES,COST-BENEFIT,CHILDREN,HUMANS,TRIAL,BRAIN,INHIBITION,EFFICACY},
  language     = {eng},
  number       = {1},
  pages        = {66--72},
  title        = {Vagus nerve stimulation for refractory epilepsy},
  url          = {http://dx.doi.org/10.1097/00013414-200103000-00007},
  volume       = {11},
  year         = {2001},
}

Chicago
Boon, Paul, Kristl Vonck, Tom Vandekerckhove, Jacques De Reuck, and Luc Calliauw. 2001. “Vagus Nerve Stimulation for Refractory Epilepsy.” Neurosurgery Quarterly 11 (1): 66–72.
APA
Boon, P., Vonck, K., Vandekerckhove, T., De Reuck, J., & Calliauw, L. (2001). Vagus nerve stimulation for refractory epilepsy. NEUROSURGERY QUARTERLY, 11(1), 66–72.
Vancouver
1.
Boon P, Vonck K, Vandekerckhove T, De Reuck J, Calliauw L. Vagus nerve stimulation for refractory epilepsy. NEUROSURGERY QUARTERLY. 2001;11(1):66–72.
MLA
Boon, Paul, Kristl Vonck, Tom Vandekerckhove, et al. “Vagus Nerve Stimulation for Refractory Epilepsy.” NEUROSURGERY QUARTERLY 11.1 (2001): 66–72. Print.