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No Compound A formation with Superia (R) during minimal-flow sevoflurane anesthesia : a comparison with Sofnolime

Marie-Paule Bouche, Linda Versichelen (UGent) , Michel Struys (UGent) , Jan Van Bocxlaer (UGent) , Andreas De Leenheer (UGent) , Eric Mortier (UGent) and Georges Rolly
(2002) ANESTHESIA AND ANALGESIA. 95(6). p.1680-1685
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Abstract
There is concern about the toxicity of Compound (Co) A. Absorbents differ in the production of Co A during minimal-flow sevoflurane anesthesia. Strong alkali-free Amsorb(R) does not produce Co A. It was our aim to study Superia(R), another new NaOH- and KOH-free CO2 absorbent, in minimal-flow anesthesia, compared with KOH-free Sofnolime(R). After Ethics Committee approval, 14 consenting adult patients were included randomly by using Superia or Sofnolime as the CO, absorbent in the compact 750-mL canister of an ADU ventilator. After propofol and remifentanil administration, sevoflurane was given in oxygen and air (500 mL/min; fraction of inspired oxygen, 0.4), aiming at an end-tidal concentration of 2.3%-2.5%; ventilation aimed for 33-35 mm Hg PETCO2 Compound A inspired (Co A(insp)) and expired (Co A(exp)) samples were taken for analysis, and canister temperatures were measured for 150 min. Statistical analysis was performed with the Friedman test or the Mann-Whitney U-test where appropriate. Correction for multiple testing was used. In the Superia group, no significant amount of Co A was formed, whereas in the Sofnolime group, maximum median (range) inspiratory values of 25 ppm (16 ppm) were found. The intergroup difference was P < 0.05. No difference was noticed between the two groups for the canister CO2 absorbent temperature.

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MLA
Bouche, Marie-Paule, et al. “No Compound A Formation with Superia (R) during Minimal-Flow Sevoflurane Anesthesia : A Comparison with Sofnolime.” ANESTHESIA AND ANALGESIA, vol. 95, no. 6, 2002, pp. 1680–85, doi:10.1097/00000539-200212000-00039.
APA
Bouche, M.-P., Versichelen, L., Struys, M., Van Bocxlaer, J., De Leenheer, A., Mortier, E., & Rolly, G. (2002). No Compound A formation with Superia (R) during minimal-flow sevoflurane anesthesia : a comparison with Sofnolime. ANESTHESIA AND ANALGESIA, 95(6), 1680–1685. https://doi.org/10.1097/00000539-200212000-00039
Chicago author-date
Bouche, Marie-Paule, Linda Versichelen, Michel Struys, Jan Van Bocxlaer, Andreas De Leenheer, Eric Mortier, and Georges Rolly. 2002. “No Compound A Formation with Superia (R) during Minimal-Flow Sevoflurane Anesthesia : A Comparison with Sofnolime.” ANESTHESIA AND ANALGESIA 95 (6): 1680–85. https://doi.org/10.1097/00000539-200212000-00039.
Chicago author-date (all authors)
Bouche, Marie-Paule, Linda Versichelen, Michel Struys, Jan Van Bocxlaer, Andreas De Leenheer, Eric Mortier, and Georges Rolly. 2002. “No Compound A Formation with Superia (R) during Minimal-Flow Sevoflurane Anesthesia : A Comparison with Sofnolime.” ANESTHESIA AND ANALGESIA 95 (6): 1680–1685. doi:10.1097/00000539-200212000-00039.
Vancouver
1.
Bouche M-P, Versichelen L, Struys M, Van Bocxlaer J, De Leenheer A, Mortier E, et al. No Compound A formation with Superia (R) during minimal-flow sevoflurane anesthesia : a comparison with Sofnolime. ANESTHESIA AND ANALGESIA. 2002;95(6):1680–5.
IEEE
[1]
M.-P. Bouche et al., “No Compound A formation with Superia (R) during minimal-flow sevoflurane anesthesia : a comparison with Sofnolime,” ANESTHESIA AND ANALGESIA, vol. 95, no. 6, pp. 1680–1685, 2002.
@article{167457,
  abstract     = {{There is concern about the toxicity of Compound (Co) A. Absorbents differ in the production of Co A during minimal-flow sevoflurane anesthesia. Strong alkali-free Amsorb(R) does not produce Co A. It was our aim to study Superia(R), another new NaOH- and KOH-free CO2 absorbent, in minimal-flow anesthesia, compared with KOH-free Sofnolime(R). After Ethics Committee approval, 14 consenting adult patients were included randomly by using Superia or Sofnolime as the CO, absorbent in the compact 750-mL canister of an ADU ventilator. After propofol and remifentanil administration, sevoflurane was given in oxygen and air (500 mL/min; fraction of inspired oxygen, 0.4), aiming at an end-tidal concentration of 2.3%-2.5%; ventilation aimed for 33-35 mm Hg PETCO2 Compound A inspired (Co A(insp)) and expired (Co A(exp)) samples were taken for analysis, and canister temperatures were measured for 150 min. Statistical analysis was performed with the Friedman test or the Mann-Whitney U-test where appropriate. Correction for multiple testing was used. In the Superia group, no significant amount of Co A was formed, whereas in the Sofnolime group, maximum median (range) inspiratory values of 25 ppm (16 ppm) were found. The intergroup difference was P < 0.05. No difference was noticed between the two groups for the canister CO2 absorbent temperature.}},
  author       = {{Bouche, Marie-Paule and Versichelen, Linda and Struys, Michel and Van Bocxlaer, Jan and De Leenheer, Andreas and Mortier, Eric and Rolly, Georges}},
  issn         = {{0003-2999}},
  journal      = {{ANESTHESIA AND ANALGESIA}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{1680--1685}},
  title        = {{No Compound A formation with Superia (R) during minimal-flow sevoflurane anesthesia : a comparison with Sofnolime}},
  url          = {{http://doi.org/10.1097/00000539-200212000-00039}},
  volume       = {{95}},
  year         = {{2002}},
}
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