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Placental inflammation and perinatal transmission of HIV-1

Fabian Mwanyumba, Philippe Gaillard, Ingrid Inion, Chris Verhofstede UGent, Patricia Claeys, Varsha Chohan, Stijn Vansteelandt UGent, Kishorchandra Mandaliya, Marleen Praet and Marleen Temmerman UGent (2002) JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES. 29(3). p.262-269
abstract
The effect of placental membrane inflammation oil mother-to-child transmission (MTCT) of HIV-1 is reported. Placentas from HIV-1-infected women were examined as part of a perinatal HIV-1 project in Mombasa, Kenya. Polymerase chain reaction analysis was used to test for HIV-1 in the infants at birth and at 6 weeks. The maternal HIV-1 seroprevalence as 13.3% (298 of 2.235). The overall rate of MTCT of HIV-1 was 25.4%: polymerase chain reaction analysis revealed that of the 201 infants 6.0% (12) were already, HIV-1-positive at birth (intrauterine transmission) and 19.4% (39) were infected during the peripartum period or in early neonatal life (perinatal transmission). The prevalence of acute chorioamnionitis was 8.8%, that of deciduitis vas 10.8%, and that of villitis vas 1.6%. Acute chorioamnionitis was independently associated with peripartum HIV-1 transmission but not with in utero MTCT (17.9% vs. 6.7%, respectively: adjusted odds ratio, 3.9: 95% confidence interval. 1.2-12.5: p = .025). Other correlates of perinatal MTCT were presence of HIV in the genital tract and in the baby's oral cavity and a high maternal viral load in peripheral blood. The adjusted population attributable fraction of 12.8% (95% confidence interval, 1.5%-22.8%) indicated that approximately 3% of MTCT could be prevented if acute chorioamnionitis A as eliminated, We suggest that further research oil the role of antimicrobial treatment in the prevention of chorioamnionitis and the reduction of peripartum MTCT needs to be performed.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
mother-to-child transmission (MTCT) risk factors, HIV-1, placental inflammation, HUMAN-IMMUNODEFICIENCY-VIRUS, MOTHER-TO-CHILD, SEXUALLY-TRANSMITTED DISEASES, PLACEBO-CONTROLLED TRIAL, TYPE-1, PREGNANCY, WOMEN, RISK, SECRETIONS, THAILAND
journal title
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
J. Acquir. Immune Defic. Syndr.
volume
29
issue
3
pages
262 - 269
Web of Science type
Article
Web of Science id
000174299600006
JCR category
INFECTIOUS DISEASES
JCR impact factor
3.902 (2002)
JCR rank
7/38 (2002)
JCR quartile
1 (2002)
ISSN
1525-4135
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
156140
handle
http://hdl.handle.net/1854/LU-156140
alternative location
http://journals.lww.com/jaids/Abstract/2002/03010/Placental_Inflammation_and_Perinatal_Transmission.6.aspx
date created
2004-01-14 13:39:00
date last changed
2016-12-19 15:38:18
@article{156140,
  abstract     = {The effect of placental membrane inflammation oil mother-to-child transmission (MTCT) of HIV-1 is reported. Placentas from HIV-1-infected women were examined as part of a perinatal HIV-1 project in Mombasa, Kenya. Polymerase chain reaction analysis was used to test for HIV-1 in the infants at birth and at 6 weeks. The maternal HIV-1 seroprevalence as 13.3\% (298 of 2.235). The overall rate of MTCT of HIV-1 was 25.4\%: polymerase chain reaction analysis revealed that of the 201 infants 6.0\% (12) were already, HIV-1-positive at birth (intrauterine transmission) and 19.4\% (39) were infected during the peripartum period or in early neonatal life (perinatal transmission). The prevalence of acute chorioamnionitis was 8.8\%, that of deciduitis vas 10.8\%, and that of villitis vas 1.6\%. Acute chorioamnionitis was independently associated with peripartum HIV-1 transmission but not with in utero MTCT (17.9\% vs. 6.7\%, respectively: adjusted odds ratio, 3.9: 95\% confidence interval. 1.2-12.5: p = .025). Other correlates of perinatal MTCT were presence of HIV in the genital tract and in the baby's oral cavity and a high maternal viral load in peripheral blood. The adjusted population attributable fraction of 12.8\% (95\% confidence interval, 1.5\%-22.8\%) indicated that approximately 3\% of MTCT could be prevented if acute chorioamnionitis A as eliminated, We suggest that further research oil the role of antimicrobial treatment in the prevention of chorioamnionitis and the reduction of peripartum MTCT needs to be performed.},
  author       = {Mwanyumba, Fabian and Gaillard, Philippe and Inion, Ingrid and Verhofstede, Chris and Claeys, Patricia and Chohan, Varsha and Vansteelandt, Stijn and Mandaliya, Kishorchandra and Praet, Marleen and Temmerman, Marleen},
  issn         = {1525-4135},
  journal      = {JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES},
  keyword      = {mother-to-child transmission (MTCT) risk factors,HIV-1,placental inflammation,HUMAN-IMMUNODEFICIENCY-VIRUS,MOTHER-TO-CHILD,SEXUALLY-TRANSMITTED DISEASES,PLACEBO-CONTROLLED TRIAL,TYPE-1,PREGNANCY,WOMEN,RISK,SECRETIONS,THAILAND},
  language     = {eng},
  number       = {3},
  pages        = {262--269},
  title        = {Placental inflammation and perinatal transmission of HIV-1},
  url          = {http://journals.lww.com/jaids/Abstract/2002/03010/Placental\_Inflammation\_and\_Perinatal\_Transmission.6.aspx},
  volume       = {29},
  year         = {2002},
}

Chicago
Mwanyumba, Fabian, Philippe Gaillard, Ingrid Inion, Chris Verhofstede, Patricia Claeys, Varsha Chohan, Stijn Vansteelandt, Kishorchandra Mandaliya, Marleen Praet, and Marleen Temmerman. 2002. “Placental Inflammation and Perinatal Transmission of HIV-1.” Journal of Acquired Immune Deficiency Syndromes 29 (3): 262–269.
APA
Mwanyumba, Fabian, Gaillard, P., Inion, I., Verhofstede, C., Claeys, P., Chohan, V., Vansteelandt, S., et al. (2002). Placental inflammation and perinatal transmission of HIV-1. JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 29(3), 262–269.
Vancouver
1.
Mwanyumba F, Gaillard P, Inion I, Verhofstede C, Claeys P, Chohan V, et al. Placental inflammation and perinatal transmission of HIV-1. JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES. 2002;29(3):262–9.
MLA
Mwanyumba, Fabian, Philippe Gaillard, Ingrid Inion, et al. “Placental Inflammation and Perinatal Transmission of HIV-1.” JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES 29.3 (2002): 262–269. Print.