Placental inflammation and perinatal transmission of HIV-1
- Author
- Fabian Mwanyumba, Philippe Gaillard, Ingrid Inion, Chris Verhofstede (UGent) , Patricia Claeys, Varsha Chohan, Stijn Vansteelandt (UGent) , Kishorchandra Mandaliya, Marleen Praet and Marleen Temmerman (UGent)
- Organization
- Abstract
- The effect of placental membrane inflammation oil mother-to-child transmission (MTCT) of HIV-1 is reported. Placentas from HIV-1-infected women were examined as part of a perinatal HIV-1 project in Mombasa, Kenya. Polymerase chain reaction analysis was used to test for HIV-1 in the infants at birth and at 6 weeks. The maternal HIV-1 seroprevalence as 13.3% (298 of 2.235). The overall rate of MTCT of HIV-1 was 25.4%: polymerase chain reaction analysis revealed that of the 201 infants 6.0% (12) were already, HIV-1-positive at birth (intrauterine transmission) and 19.4% (39) were infected during the peripartum period or in early neonatal life (perinatal transmission). The prevalence of acute chorioamnionitis was 8.8%, that of deciduitis vas 10.8%, and that of villitis vas 1.6%. Acute chorioamnionitis was independently associated with peripartum HIV-1 transmission but not with in utero MTCT (17.9% vs. 6.7%, respectively: adjusted odds ratio, 3.9: 95% confidence interval. 1.2-12.5: p = .025). Other correlates of perinatal MTCT were presence of HIV in the genital tract and in the baby's oral cavity and a high maternal viral load in peripheral blood. The adjusted population attributable fraction of 12.8% (95% confidence interval, 1.5%-22.8%) indicated that approximately 3% of MTCT could be prevented if acute chorioamnionitis A as eliminated, We suggest that further research oil the role of antimicrobial treatment in the prevention of chorioamnionitis and the reduction of peripartum MTCT needs to be performed.
- Keywords
- mother-to-child transmission (MTCT) risk factors, HIV-1, placental inflammation, HUMAN-IMMUNODEFICIENCY-VIRUS, MOTHER-TO-CHILD, SEXUALLY-TRANSMITTED DISEASES, PLACEBO-CONTROLLED TRIAL, TYPE-1, PREGNANCY, WOMEN, RISK, SECRETIONS, THAILAND
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-156140
- MLA
- Mwanyumba, Fabian, et al. “Placental Inflammation and Perinatal Transmission of HIV-1.” JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, vol. 29, no. 3, 2002, pp. 262–69.
- APA
- Mwanyumba, F., Gaillard, P., Inion, I., Verhofstede, C., Claeys, P., Chohan, V., … Temmerman, M. (2002). Placental inflammation and perinatal transmission of HIV-1. JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 29(3), 262–269.
- Chicago author-date
- Mwanyumba, Fabian, Philippe Gaillard, Ingrid Inion, Chris Verhofstede, Patricia Claeys, Varsha Chohan, Stijn Vansteelandt, Kishorchandra Mandaliya, Marleen Praet, and Marleen Temmerman. 2002. “Placental Inflammation and Perinatal Transmission of HIV-1.” JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES 29 (3): 262–69.
- Chicago author-date (all authors)
- Mwanyumba, Fabian, Philippe Gaillard, Ingrid Inion, Chris Verhofstede, Patricia Claeys, Varsha Chohan, Stijn Vansteelandt, Kishorchandra Mandaliya, Marleen Praet, and Marleen Temmerman. 2002. “Placental Inflammation and Perinatal Transmission of HIV-1.” JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES 29 (3): 262–269.
- Vancouver
- 1.Mwanyumba F, Gaillard P, Inion I, Verhofstede C, Claeys P, Chohan V, et al. Placental inflammation and perinatal transmission of HIV-1. JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES. 2002;29(3):262–9.
- IEEE
- [1]F. Mwanyumba et al., “Placental inflammation and perinatal transmission of HIV-1,” JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, vol. 29, no. 3, pp. 262–269, 2002.
@article{156140, abstract = {{The effect of placental membrane inflammation oil mother-to-child transmission (MTCT) of HIV-1 is reported. Placentas from HIV-1-infected women were examined as part of a perinatal HIV-1 project in Mombasa, Kenya. Polymerase chain reaction analysis was used to test for HIV-1 in the infants at birth and at 6 weeks. The maternal HIV-1 seroprevalence as 13.3% (298 of 2.235). The overall rate of MTCT of HIV-1 was 25.4%: polymerase chain reaction analysis revealed that of the 201 infants 6.0% (12) were already, HIV-1-positive at birth (intrauterine transmission) and 19.4% (39) were infected during the peripartum period or in early neonatal life (perinatal transmission). The prevalence of acute chorioamnionitis was 8.8%, that of deciduitis vas 10.8%, and that of villitis vas 1.6%. Acute chorioamnionitis was independently associated with peripartum HIV-1 transmission but not with in utero MTCT (17.9% vs. 6.7%, respectively: adjusted odds ratio, 3.9: 95% confidence interval. 1.2-12.5: p = .025). Other correlates of perinatal MTCT were presence of HIV in the genital tract and in the baby's oral cavity and a high maternal viral load in peripheral blood. The adjusted population attributable fraction of 12.8% (95% confidence interval, 1.5%-22.8%) indicated that approximately 3% of MTCT could be prevented if acute chorioamnionitis A as eliminated, We suggest that further research oil the role of antimicrobial treatment in the prevention of chorioamnionitis and the reduction of peripartum MTCT needs to be performed.}}, author = {{Mwanyumba, Fabian and Gaillard, Philippe and Inion, Ingrid and Verhofstede, Chris and Claeys, Patricia and Chohan, Varsha and Vansteelandt, Stijn and Mandaliya, Kishorchandra and Praet, Marleen and Temmerman, Marleen}}, issn = {{1525-4135}}, journal = {{JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES}}, keywords = {{mother-to-child transmission (MTCT) risk factors,HIV-1,placental inflammation,HUMAN-IMMUNODEFICIENCY-VIRUS,MOTHER-TO-CHILD,SEXUALLY-TRANSMITTED DISEASES,PLACEBO-CONTROLLED TRIAL,TYPE-1,PREGNANCY,WOMEN,RISK,SECRETIONS,THAILAND}}, language = {{eng}}, number = {{3}}, pages = {{262--269}}, title = {{Placental inflammation and perinatal transmission of HIV-1}}, url = {{http://journals.lww.com/jaids/Abstract/2002/03010/Placental_Inflammation_and_Perinatal_Transmission.6.aspx}}, volume = {{29}}, year = {{2002}}, }