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Prevalence of vulvovaginal candidiasis and susceptibility to fluconazole in women

Tieneke Bauters, Marc Dhont, Marleen Temmerman UGent and Hans Nelis UGent (2002) AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY. 187(3). p.569-574
abstract
OBJECTIVE: The purpose of this study was to determine the prevalence of vaginal colonization by Candida with the use of a rapid detection method, to examine the determinants of vaginal candidiasis, and to evaluate susceptibility for fluconazole. STUDY DESIGN: Vaginal swabs were collected from unselected women at the outpatient clinic of the Department of Obstetrics and Gynecology. A differentiation was made between patients with a positive and a negative potassium hydroxide examination. RESULTS: Six hundred twelve women were recruited, of whom 39 women (6.3%) had clinical candidiasis. The overall rate of yeast colonization was 20.1%. Candida albicans was isolated most frequently(68.3%), followed by C glabrata (16.3%) and C parapsilosis (8.9%). Clinical candidiasis was related positively with the state of estrogen impregnation. In vitro susceptibility testing by the National Committee for Clinical Laboratory Standards method for fluconazole revealed that 21.1% of the isolates were resistant. CONCLUSION: More than 20% of the unselected women were colonized with Candida species. Hyperestrogenemia was associated with an increased vulvovaginal colonization by Candida. Surprisingly, 21% of the isolates was resistant to fluconazole, according to the National Committee for Clinical Laboratory Standards method.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
antifungal, vulvovaginal candidiasis, susceptibility, VULVO-VAGINAL CANDIDIASIS, VAGINITIS, FLORA
journal title
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
Am. J. Obstet. Gynecol.
volume
187
issue
3
pages
569 - 574
Web of Science type
Article
Web of Science id
000178256400009
JCR category
OBSTETRICS & GYNECOLOGY
JCR impact factor
2.556 (2002)
JCR rank
5/52 (2002)
JCR quartile
1 (2002)
ISSN
0002-9378
DOI
10.1067/mob.2002.125897
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
155685
handle
http://hdl.handle.net/1854/LU-155685
date created
2004-01-14 13:39:00
date last changed
2016-12-19 15:38:20
@article{155685,
  abstract     = {OBJECTIVE: The purpose of this study was to determine the prevalence of vaginal colonization by Candida with the use of a rapid detection method, to examine the determinants of vaginal candidiasis, and to evaluate susceptibility for fluconazole.
STUDY DESIGN: Vaginal swabs were collected from unselected women at the outpatient clinic of the Department of Obstetrics and Gynecology. A differentiation was made between patients with a positive and a negative potassium hydroxide examination.
RESULTS: Six hundred twelve women were recruited, of whom 39 women (6.3\%) had clinical candidiasis. The overall rate of yeast colonization was 20.1\%. Candida albicans was isolated most frequently(68.3\%), followed by C glabrata (16.3\%) and C parapsilosis (8.9\%). Clinical candidiasis was related positively with the state of estrogen impregnation. In vitro susceptibility testing by the National Committee for Clinical Laboratory Standards method for fluconazole revealed that 21.1\% of the isolates were resistant.
CONCLUSION: More than 20\% of the unselected women were colonized with Candida species. Hyperestrogenemia was associated with an increased vulvovaginal colonization by Candida. Surprisingly, 21\% of the isolates was resistant to fluconazole, according to the National Committee for Clinical Laboratory Standards method.},
  author       = {Bauters, Tieneke and Dhont, Marc and Temmerman, Marleen and Nelis, Hans},
  issn         = {0002-9378},
  journal      = {AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY},
  keyword      = {antifungal,vulvovaginal candidiasis,susceptibility,VULVO-VAGINAL CANDIDIASIS,VAGINITIS,FLORA},
  language     = {eng},
  number       = {3},
  pages        = {569--574},
  title        = {Prevalence of vulvovaginal candidiasis and susceptibility to fluconazole in women},
  url          = {http://dx.doi.org/10.1067/mob.2002.125897},
  volume       = {187},
  year         = {2002},
}

Chicago
BAUTERS, TIENEKE, MARC DHONT, Marleen Temmerman, and Hans Nelis. 2002. “Prevalence of Vulvovaginal Candidiasis and Susceptibility to Fluconazole in Women.” American Journal of Obstetrics and Gynecology 187 (3): 569–574.
APA
BAUTERS, T., DHONT, M., Temmerman, M., & Nelis, H. (2002). Prevalence of vulvovaginal candidiasis and susceptibility to fluconazole in women. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 187(3), 569–574.
Vancouver
1.
BAUTERS T, DHONT M, Temmerman M, Nelis H. Prevalence of vulvovaginal candidiasis and susceptibility to fluconazole in women. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY. 2002;187(3):569–74.
MLA
BAUTERS, TIENEKE, MARC DHONT, Marleen Temmerman, et al. “Prevalence of Vulvovaginal Candidiasis and Susceptibility to Fluconazole in Women.” AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY 187.3 (2002): 569–574. Print.