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Functional brain imaging of serotonin-2A receptors in impulsive dogs: a pilot study

Peremans, Kathelijne UGent, Audenaert, Kurt UGent, Coopman, Frank UGent, Hoybergs, Y, Slegers, Guido, van Bree, Henri UGent, Verschooten, Francis and Dierckx, Rudi UGent (2002) VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT. 71(5). p.340-347
abstract
Impulsive, disinhibited behavior in dogs, which comes to expression as aggression, has a major impact on public health. Measures taken without a real understanding of the underlying pathology are unlikely to be effective. It would therefore be not only of pathophysiological but also of clinical relevance to develop a research paradigm to investigate this aberrant behavior in dogs. The first aim of this article is to review the literature concerning functional-anatomical and biochemical research on animal impulsivity. On the basis of this research, a hypothesis involving the prefrontal serotonin-2A receptor in the frontal cortex is generated and the feasibility of quantifying the 5-HT2A receptor with Single Photon Emission Computed Tomography (SPECT) and the highly selective receptor radioligand I-123-5I-R91150 is presented in a pilot study. If confirmed, this hypothesis may lead to the development of an in vivo research tool for investigating behavioral disorders and a modality for monitoring the effects of pharmacologic interventions and behavior therapy.
Please use this url to cite or link to this publication:
author
organization
alternative title
Functionele beeldvorming van serotonine-2A receptoren in de hersenen van impulsief-agressieve honden
year
type
journalArticle (original)
publication status
published
subject
keyword
VERVET MONKEYS, BINDING-SITES, NONHUMAN-PRIMATES, DOMINANCE AGGRESSION, CEREBROSPINAL-FLUID, TRYPTOPHAN DEPLETION, POSITRON-EMISSION-TOMOGRAPHY, LOW CSF 5-HIAA, CSF5-HIAA, BEHAVIOR
journal title
VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT
Vlaams Diergeneesk. Tijdschr.
volume
71
issue
5
pages
340 - 347
Web of Science type
Article
Web of Science id
000179288700002
JCR category
VETERINARY SCIENCES
JCR impact factor
0.162 (2002)
JCR rank
107/129 (2002)
JCR quartile
4 (2002)
ISSN
0303-9021
language
English
UGent publication?
yes
classification
A1
copyright statement
I have retained and own the full copyright for this publication
id
155158
handle
http://hdl.handle.net/1854/LU-155158
alternative location
http://vdt.ugent.be/sites/default/files/art71506.pdf
date created
2004-01-14 13:39:00
date last changed
2016-12-19 15:38:56
@article{155158,
  abstract     = {Impulsive, disinhibited behavior in dogs, which comes to expression as aggression, has a major impact on public health. Measures taken without a real understanding of the underlying pathology are unlikely to be effective. It would therefore be not only of pathophysiological but also of clinical relevance to develop a research paradigm to investigate this aberrant behavior in dogs. The first aim of this article is to review the literature concerning functional-anatomical and biochemical research on animal impulsivity. On the basis of this research, a hypothesis involving the prefrontal serotonin-2A receptor in the frontal cortex is generated and the feasibility of quantifying the 5-HT2A receptor with Single Photon Emission Computed Tomography (SPECT) and the highly selective receptor radioligand I-123-5I-R91150 is presented in a pilot study. If confirmed, this hypothesis may lead to the development of an in vivo research tool for investigating behavioral disorders and a modality for monitoring the effects of pharmacologic interventions and behavior therapy.},
  author       = {Peremans, Kathelijne and Audenaert, Kurt and Coopman, Frank and Hoybergs, Y and Slegers, Guido and van Bree, Henri and Verschooten, Francis and Dierckx, Rudi},
  issn         = {0303-9021},
  journal      = {VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT},
  keyword      = {VERVET MONKEYS,BINDING-SITES,NONHUMAN-PRIMATES,DOMINANCE AGGRESSION,CEREBROSPINAL-FLUID,TRYPTOPHAN DEPLETION,POSITRON-EMISSION-TOMOGRAPHY,LOW CSF 5-HIAA,CSF5-HIAA,BEHAVIOR},
  language     = {eng},
  number       = {5},
  pages        = {340--347},
  title        = {Functional brain imaging of serotonin-2A receptors in impulsive dogs: a pilot study},
  url          = {http://vdt.ugent.be/sites/default/files/art71506.pdf},
  volume       = {71},
  year         = {2002},
}

Chicago
Peremans, Kathelijne, Kurt Audenaert, Frank Coopman, Y Hoybergs, Guido Slegers, Henri van Bree, Francis Verschooten, and Rudi Dierckx. 2002. “Functional Brain Imaging of serotonin-2A Receptors in Impulsive Dogs: a Pilot Study.” Vlaams Diergeneeskundig Tijdschrift 71 (5): 340–347.
APA
Peremans, K., Audenaert, K., Coopman, F., Hoybergs, Y., Slegers, G., van Bree, H., Verschooten, F., et al. (2002). Functional brain imaging of serotonin-2A receptors in impulsive dogs: a pilot study. VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT, 71(5), 340–347.
Vancouver
1.
Peremans K, Audenaert K, Coopman F, Hoybergs Y, Slegers G, van Bree H, et al. Functional brain imaging of serotonin-2A receptors in impulsive dogs: a pilot study. VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT. 2002;71(5):340–7.
MLA
Peremans, Kathelijne, Kurt Audenaert, Frank Coopman, et al. “Functional Brain Imaging of serotonin-2A Receptors in Impulsive Dogs: a Pilot Study.” VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT 71.5 (2002): 340–347. Print.