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Functional brain imaging of serotonin-2A receptors in impulsive dogs: a pilot study

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Abstract
Impulsive, disinhibited behavior in dogs, which comes to expression as aggression, has a major impact on public health. Measures taken without a real understanding of the underlying pathology are unlikely to be effective. It would therefore be not only of pathophysiological but also of clinical relevance to develop a research paradigm to investigate this aberrant behavior in dogs. The first aim of this article is to review the literature concerning functional-anatomical and biochemical research on animal impulsivity. On the basis of this research, a hypothesis involving the prefrontal serotonin-2A receptor in the frontal cortex is generated and the feasibility of quantifying the 5-HT2A receptor with Single Photon Emission Computed Tomography (SPECT) and the highly selective receptor radioligand I-123-5I-R91150 is presented in a pilot study. If confirmed, this hypothesis may lead to the development of an in vivo research tool for investigating behavioral disorders and a modality for monitoring the effects of pharmacologic interventions and behavior therapy.
Keywords
VERVET MONKEYS, BINDING-SITES, NONHUMAN-PRIMATES, DOMINANCE AGGRESSION, CEREBROSPINAL-FLUID, TRYPTOPHAN DEPLETION, POSITRON-EMISSION-TOMOGRAPHY, LOW CSF 5-HIAA, CSF5-HIAA, BEHAVIOR

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Citation

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Chicago
Peremans, Kathelijne, Kurt Audenaert, Frank Coopman, Y Hoybergs, Guido Slegers, Henri van Bree, Francis Verschooten, and Rudi Dierckx. 2002. “Functional Brain Imaging of serotonin-2A Receptors in Impulsive Dogs: a Pilot Study.” Vlaams Diergeneeskundig Tijdschrift 71 (5): 340–347.
APA
Peremans, K., Audenaert, K., Coopman, F., Hoybergs, Y., Slegers, G., van Bree, H., Verschooten, F., et al. (2002). Functional brain imaging of serotonin-2A receptors in impulsive dogs: a pilot study. VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT, 71(5), 340–347.
Vancouver
1.
Peremans K, Audenaert K, Coopman F, Hoybergs Y, Slegers G, van Bree H, et al. Functional brain imaging of serotonin-2A receptors in impulsive dogs: a pilot study. VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT. 2002;71(5):340–7.
MLA
Peremans, Kathelijne, Kurt Audenaert, Frank Coopman, et al. “Functional Brain Imaging of serotonin-2A Receptors in Impulsive Dogs: a Pilot Study.” VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT 71.5 (2002): 340–347. Print.
@article{155158,
  abstract     = {Impulsive, disinhibited behavior in dogs, which comes to expression as aggression, has a major impact on public health. Measures taken without a real understanding of the underlying pathology are unlikely to be effective. It would therefore be not only of pathophysiological but also of clinical relevance to develop a research paradigm to investigate this aberrant behavior in dogs. The first aim of this article is to review the literature concerning functional-anatomical and biochemical research on animal impulsivity. On the basis of this research, a hypothesis involving the prefrontal serotonin-2A receptor in the frontal cortex is generated and the feasibility of quantifying the 5-HT2A receptor with Single Photon Emission Computed Tomography (SPECT) and the highly selective receptor radioligand I-123-5I-R91150 is presented in a pilot study. If confirmed, this hypothesis may lead to the development of an in vivo research tool for investigating behavioral disorders and a modality for monitoring the effects of pharmacologic interventions and behavior therapy.},
  author       = {Peremans, Kathelijne and Audenaert, Kurt and Coopman, Frank and Hoybergs, Y and Slegers, Guido and van Bree, Henri and Verschooten, Francis and Dierckx, Rudi},
  issn         = {0303-9021},
  journal      = {VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT},
  keyword      = {VERVET MONKEYS,BINDING-SITES,NONHUMAN-PRIMATES,DOMINANCE AGGRESSION,CEREBROSPINAL-FLUID,TRYPTOPHAN DEPLETION,POSITRON-EMISSION-TOMOGRAPHY,LOW CSF 5-HIAA,CSF5-HIAA,BEHAVIOR},
  language     = {eng},
  number       = {5},
  pages        = {340--347},
  title        = {Functional brain imaging of serotonin-2A receptors in impulsive dogs: a pilot study},
  url          = {http://vdt.ugent.be/sites/default/files/art71506.pdf},
  volume       = {71},
  year         = {2002},
}

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