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A universal role for MyD88 in TLR/IL-1R-mediated signaling

Sophie Janssens (UGent) and Rudi Beyaert (UGent)
(2002) TRENDS IN BIOCHEMICAL SCIENCES. 27(9). p.474-482
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Abstract
The MyD88 adapter protein links members of the toll-like receptor (TLR) and interleukin-1 receptor (IL-1R) superfamily to the downstream activation of nuclear factor-kappaB and mitogen-activated protein kinases. Although originally identified as a myeloid-differentiation marker, MyD88 is now known to play an essential role in the innate immune response of insects and mammals. The generation of MyD88-deficient mice, as well as the identification of MyD88-related proteins and regulators of MyD88 signaling, has revealed new and important insights into the function of MyD88.
Keywords
TOLL-LIKE RECEPTORS, NF-KAPPA-B, IMMEDIATE EARLY RESPONSE, IL-1 RECEPTOR, ADAPTER PROTEIN, MOLECULAR CHARACTERIZATION, TERMINAL DIFFERENTIATION, TRANSDUCTION PATHWAY, DROSOPHILA MYD88, DEATH DOMAIN

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Citation

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Chicago
Janssens, Sophie, and Rudi Beyaert. 2002. “A Universal Role for MyD88 in TLR/IL-1R-mediated Signaling.” Trends in Biochemical Sciences 27 (9): 474–482.
APA
Janssens, Sophie, & Beyaert, R. (2002). A universal role for MyD88 in TLR/IL-1R-mediated signaling. TRENDS IN BIOCHEMICAL SCIENCES, 27(9), 474–482.
Vancouver
1.
Janssens S, Beyaert R. A universal role for MyD88 in TLR/IL-1R-mediated signaling. TRENDS IN BIOCHEMICAL SCIENCES. 2002;27(9):474–82.
MLA
Janssens, Sophie, and Rudi Beyaert. “A Universal Role for MyD88 in TLR/IL-1R-mediated Signaling.” TRENDS IN BIOCHEMICAL SCIENCES 27.9 (2002): 474–482. Print.
@article{154588,
  abstract     = {The MyD88 adapter protein links members of the toll-like receptor (TLR) and interleukin-1 receptor (IL-1R) superfamily to the downstream activation of nuclear factor-kappaB and mitogen-activated protein kinases. Although originally identified as a myeloid-differentiation marker, MyD88 is now known to play an essential role in the innate immune response of insects and mammals. The generation of MyD88-deficient mice, as well as the identification of MyD88-related proteins and regulators of MyD88 signaling, has revealed new and important insights into the function of MyD88.},
  author       = {Janssens, Sophie and Beyaert, Rudi},
  issn         = {0968-0004},
  journal      = {TRENDS IN BIOCHEMICAL SCIENCES},
  keywords     = {TOLL-LIKE RECEPTORS,NF-KAPPA-B,IMMEDIATE EARLY RESPONSE,IL-1 RECEPTOR,ADAPTER PROTEIN,MOLECULAR CHARACTERIZATION,TERMINAL DIFFERENTIATION,TRANSDUCTION PATHWAY,DROSOPHILA MYD88,DEATH DOMAIN},
  language     = {eng},
  number       = {9},
  pages        = {474--482},
  title        = {A universal role for MyD88 in TLR/IL-1R-mediated signaling},
  url          = {http://dx.doi.org/10.1016/S0968-0004(02)02145-X},
  volume       = {27},
  year         = {2002},
}

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