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Control of proliferation, endoreduplication and differentiation by the Arabidopsis E2Fa-DPa transcription factor

Lieven De Veylder (UGent) , Tom Beeckman (UGent) , Gerrit Beemster (UGent) , Janice de Almeida Engler (UGent) , Sandra Ormenese, Sara Maes (UGent) , Mirande Naudts (UGent) , Els Van Der Schueren (UGent) , Annie Jacqmard, Gilbert Engler (UGent) , et al.
(2002) EMBO JOURNAL. 21(6). p.1360-1368
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Abstract
New plant cells arise at the meristems, where they divide a few times before they leave the cell-cycle program and start to differentiate. Here we show that the E2Fa-DPa transcription factor of Arabidopsis thaliana is a key regulator determining the proliferative status of plant cells. Ectopic expression of E2Fa induced sustained cell proliferation in normally differentiated cotyledon and hypocotyl cells. The phenotype was enhanced strongly by the co-expression of E2Fa with its dimerization partner, DPa. In endoreduplicating cells, E2Fa-DPa also caused extra DNA replication that was correlated with transcriptional induction of S phase genes. Because E2Fa-DPa transgenic plants arrested early in development, we argue that controlled exit of the cell cycle is a prerequisite for normal plant development.
Keywords
Arabidopsis thaliana, cell differentiation, cell cycle, E2F-DP transcription, endoreduplication, E2F FAMILY MEMBERS, S-PHASE ENTRY, CELL-CYCLE, RETINOBLASTOMA PROTEIN, HISTONE DEACETYLASE, MEDIATED TRANSFORMATION, REPRESS TRANSCRIPTION, THALIANA, PLANT E2F, EXPRESSION

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Citation

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MLA
De Veylder, Lieven, et al. “Control of Proliferation, Endoreduplication and Differentiation by the Arabidopsis E2Fa-DPa Transcription Factor.” EMBO JOURNAL, vol. 21, no. 6, 2002, pp. 1360–68, doi:10.1093/emboj/21.6.1360.
APA
De Veylder, L., Beeckman, T., Beemster, G., de Almeida Engler, J., Ormenese, S., Maes, S., … Inzé, D. (2002). Control of proliferation, endoreduplication and differentiation by the Arabidopsis E2Fa-DPa transcription factor. EMBO JOURNAL, 21(6), 1360–1368. https://doi.org/10.1093/emboj/21.6.1360
Chicago author-date
De Veylder, Lieven, Tom Beeckman, Gerrit Beemster, Janice de Almeida Engler, Sandra Ormenese, Sara Maes, Mirande Naudts, et al. 2002. “Control of Proliferation, Endoreduplication and Differentiation by the Arabidopsis E2Fa-DPa Transcription Factor.” EMBO JOURNAL 21 (6): 1360–68. https://doi.org/10.1093/emboj/21.6.1360.
Chicago author-date (all authors)
De Veylder, Lieven, Tom Beeckman, Gerrit Beemster, Janice de Almeida Engler, Sandra Ormenese, Sara Maes, Mirande Naudts, Els Van Der Schueren, Annie Jacqmard, Gilbert Engler, and Dirk Inzé. 2002. “Control of Proliferation, Endoreduplication and Differentiation by the Arabidopsis E2Fa-DPa Transcription Factor.” EMBO JOURNAL 21 (6): 1360–1368. doi:10.1093/emboj/21.6.1360.
Vancouver
1.
De Veylder L, Beeckman T, Beemster G, de Almeida Engler J, Ormenese S, Maes S, et al. Control of proliferation, endoreduplication and differentiation by the Arabidopsis E2Fa-DPa transcription factor. EMBO JOURNAL. 2002;21(6):1360–8.
IEEE
[1]
L. De Veylder et al., “Control of proliferation, endoreduplication and differentiation by the Arabidopsis E2Fa-DPa transcription factor,” EMBO JOURNAL, vol. 21, no. 6, pp. 1360–1368, 2002.
@article{153874,
  abstract     = {{New plant cells arise at the meristems, where they divide a few times before they leave the cell-cycle program and start to differentiate. Here we show that the E2Fa-DPa transcription factor of Arabidopsis thaliana is a key regulator determining the proliferative status of plant cells. Ectopic expression of E2Fa induced sustained cell proliferation in normally differentiated cotyledon and hypocotyl cells. The phenotype was enhanced strongly by the co-expression of E2Fa with its dimerization partner, DPa. In endoreduplicating cells, E2Fa-DPa also caused extra DNA replication that was correlated with transcriptional induction of S phase genes. Because E2Fa-DPa transgenic plants arrested early in development, we argue that controlled exit of the cell cycle is a prerequisite for normal plant development.}},
  author       = {{De Veylder, Lieven and Beeckman, Tom and Beemster, Gerrit and de Almeida Engler, Janice and Ormenese, Sandra and Maes, Sara and Naudts, Mirande and Van Der Schueren, Els and Jacqmard, Annie and Engler, Gilbert and Inzé, Dirk}},
  issn         = {{0261-4189}},
  journal      = {{EMBO JOURNAL}},
  keywords     = {{Arabidopsis thaliana,cell differentiation,cell cycle,E2F-DP transcription,endoreduplication,E2F FAMILY MEMBERS,S-PHASE ENTRY,CELL-CYCLE,RETINOBLASTOMA PROTEIN,HISTONE DEACETYLASE,MEDIATED TRANSFORMATION,REPRESS TRANSCRIPTION,THALIANA,PLANT E2F,EXPRESSION}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{1360--1368}},
  title        = {{Control of proliferation, endoreduplication and differentiation by the Arabidopsis E2Fa-DPa transcription factor}},
  url          = {{http://doi.org/10.1093/emboj/21.6.1360}},
  volume       = {{21}},
  year         = {{2002}},
}
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