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Control of proliferation, endoreduplication and differentiation by the Arabidopsis E2Fa-DPa transcription factor

Lieven De Veylder UGent, Tom Beeckman UGent, Gerrit Beemster UGent, Janice de Almeida Engler UGent, Sandra Ormenese, Sara Maes UGent, Mirande Naudts UGent, Els Van Der Schueren, Annie Jacqmard, Gilbert Engler UGent, et al. (2002) EMBO JOURNAL. 21(6). p.1360-1368
abstract
New plant cells arise at the meristems, where they divide a few times before they leave the cell-cycle program and start to differentiate. Here we show that the E2Fa-DPa transcription factor of Arabidopsis thaliana is a key regulator determining the proliferative status of plant cells. Ectopic expression of E2Fa induced sustained cell proliferation in normally differentiated cotyledon and hypocotyl cells. The phenotype was enhanced strongly by the co-expression of E2Fa with its dimerization partner, DPa. In endoreduplicating cells, E2Fa-DPa also caused extra DNA replication that was correlated with transcriptional induction of S phase genes. Because E2Fa-DPa transgenic plants arrested early in development, we argue that controlled exit of the cell cycle is a prerequisite for normal plant development.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
Arabidopsis thaliana, cell differentiation, cell cycle, E2F-DP transcription, endoreduplication, E2F FAMILY MEMBERS, S-PHASE ENTRY, CELL-CYCLE, RETINOBLASTOMA PROTEIN, HISTONE DEACETYLASE, MEDIATED TRANSFORMATION, REPRESS TRANSCRIPTION, THALIANA, PLANT E2F, EXPRESSION
journal title
EMBO JOURNAL
Embo J.
volume
21
issue
6
pages
1360 - 1368
Web of Science type
Article
Web of Science id
000174398900012
JCR category
BIOCHEMISTRY & MOLECULAR BIOLOGY
JCR impact factor
10.698 (2002)
JCR rank
9/263 (2002)
JCR quartile
1 (2002)
ISSN
0261-4189
DOI
10.1093/emboj/21.6.1360
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
153874
handle
http://hdl.handle.net/1854/LU-153874
date created
2004-01-14 13:38:00
date last changed
2016-12-19 15:38:18
@article{153874,
  abstract     = {New plant cells arise at the meristems, where they divide a few times before they leave the cell-cycle program and start to differentiate. Here we show that the E2Fa-DPa transcription factor of Arabidopsis thaliana is a key regulator determining the proliferative status of plant cells. Ectopic expression of E2Fa induced sustained cell proliferation in normally differentiated cotyledon and hypocotyl cells. The phenotype was enhanced strongly by the co-expression of E2Fa with its dimerization partner, DPa. In endoreduplicating cells, E2Fa-DPa also caused extra DNA replication that was correlated with transcriptional induction of S phase genes. Because E2Fa-DPa transgenic plants arrested early in development, we argue that controlled exit of the cell cycle is a prerequisite for normal plant development.},
  author       = {De Veylder, Lieven and Beeckman, Tom and Beemster, Gerrit and de Almeida Engler, Janice and Ormenese, Sandra and Maes, Sara and Naudts, Mirande and Van Der Schueren, Els and Jacqmard, Annie and Engler, Gilbert and Inz{\'e}, Dirk},
  issn         = {0261-4189},
  journal      = {EMBO JOURNAL},
  keyword      = {Arabidopsis thaliana,cell differentiation,cell cycle,E2F-DP transcription,endoreduplication,E2F FAMILY MEMBERS,S-PHASE ENTRY,CELL-CYCLE,RETINOBLASTOMA PROTEIN,HISTONE DEACETYLASE,MEDIATED TRANSFORMATION,REPRESS TRANSCRIPTION,THALIANA,PLANT E2F,EXPRESSION},
  language     = {eng},
  number       = {6},
  pages        = {1360--1368},
  title        = {Control of proliferation, endoreduplication and differentiation by the Arabidopsis E2Fa-DPa transcription factor},
  url          = {http://dx.doi.org/10.1093/emboj/21.6.1360},
  volume       = {21},
  year         = {2002},
}

Chicago
De Veylder, Lieven, Tom Beeckman, Gerrit Beemster, Janice de Almeida Engler, Sandra Ormenese, Sara Maes, Mirande Naudts, et al. 2002. “Control of Proliferation, Endoreduplication and Differentiation by the Arabidopsis E2Fa-DPa Transcription Factor.” Embo Journal 21 (6): 1360–1368.
APA
De Veylder, L., Beeckman, T., Beemster, G., de Almeida Engler, J., Ormenese, S., Maes, S., Naudts, M., et al. (2002). Control of proliferation, endoreduplication and differentiation by the Arabidopsis E2Fa-DPa transcription factor. EMBO JOURNAL, 21(6), 1360–1368.
Vancouver
1.
De Veylder L, Beeckman T, Beemster G, de Almeida Engler J, Ormenese S, Maes S, et al. Control of proliferation, endoreduplication and differentiation by the Arabidopsis E2Fa-DPa transcription factor. EMBO JOURNAL. 2002;21(6):1360–8.
MLA
De Veylder, Lieven, Tom Beeckman, Gerrit Beemster, et al. “Control of Proliferation, Endoreduplication and Differentiation by the Arabidopsis E2Fa-DPa Transcription Factor.” EMBO JOURNAL 21.6 (2002): 1360–1368. Print.