@article{153786,
  abstract     = {{The struwwelpeter (swp) mutant in Arabidopsis shows reduced cell numbers in all aerial organs. In certain cases, this defect is partially compensated by an increase in final cell size. Although the mutation does not affect cell cycle duration in the young primordia, it does influence the window of cell proliferation, as cell number is reduced during the very early stages of primordium initiation and a precocious arrest of cell proliferation occurs. In addition, the mutation also perturbs the shoot apical meristem (SAM), which becomes gradually disorganized. SWP encodes a protein with similarities to subunits of the Mediator complex, required for RNA polymerase II recruitment at target promoters in response to specific activators. To gain further insight into its function, we overexpressed the gene under the control of a constitutive promoter. This interfered again with the moment of cell cycle arrest in the young leaf. Our results suggest that the levels of SWP, besides their role in pattern formation at the meristem, play an important role in defining the duration of cell proliferation.}},
  author       = {{Autran, Daphné and Jonak, Claudia and Belcram, Katia and Beemster, Gerrit and Kronenberger, Jocelyne and Grandjean, Olivier and Inzé, Dirk and Traas, Jan}},
  issn         = {{0261-4189}},
  journal      = {{EMBO JOURNAL}},
  keywords     = {{shoot apical meristem,primordia,SHOOT APICAL MERISTEM,HORMONE RECEPTOR FUNCTION,SIZE CONTROL,ANIMAL DEVELOPMENT,NUCLEAR RECEPTORS,THALIANA,PROTEIN,COMPLEX,leaf development,Mediator complex,MEDIATOR,DIVISION}},
  language     = {{eng}},
  number       = {{22}},
  pages        = {{6036--6049}},
  title        = {{Cell numbers and leaf development in Arabidopsis: a functional analysis of the STRUWWELPETER gene}},
  url          = {{http://doi.org/10.1093/emboj/cdf614}},
  volume       = {{21}},
  year         = {{2002}},
}

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