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The αE-catenin gene (CTNNA1) acts as an invasion-suppressor gene in human colon cancer cells

(1999) ONCOGENE. 18(4). p.905-915
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Abstract
The acquisition of invasiveness is a crucial step in the malignant progression of cancer. In cancers of the colon and of other organs the E-cadherin/catenin complex, which is implicated in homotypic cell-cell adhesion as well as in signal transduction, serves as a powerful inhibitor of invasion. We show here that one allele of the alpha E-catenin (CTNNA1) gene is mutated in the human colon cancer cell family HCT-8, which is identical to HCT-15, DLD-1 and HRT-18. Genetic instability, due to mutations in the HMSH6 (also called GTBP) mismatch repair gene, results in the spontaneous occurrence of invasive variants, all carrying either a mutation or exon skipping in the second alpha E-catenin allele, The alpha E-catenin gene is therefore, an invasion-suppressor gene in accordance with the two-hit model of Knudsen for tumour-suppressor genes.
Keywords
colon cancer, invasion, alpha E-catenin, genetic instability, NONPOLYPOSIS COLORECTAL-CARCINOMA, II RECEPTOR GENE, E-CADHERIN, MICROSATELLITE INSTABILITY, GROWTH-FACTOR, LYNCH SYNDROME, RETINOIC ACID, BETA-CATENIN, TUMOR-CELLS, MUTATIONS

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Chicago
Vermeulen, Stefan, Friedel Nollet, E TEUGELS, KM VENNEKENS, F MALFAIT, Jan Philippé, Franki Speleman, Marc Bracke, Frans Van Roy, and Marcus Mareel. 1999. “The αE-catenin Gene (CTNNA1) Acts as an Invasion-suppressor Gene in Human Colon Cancer Cells.” Oncogene 18 (4): 905–915.
APA
Vermeulen, Stefan, Nollet, F., TEUGELS, E., VENNEKENS, K., MALFAIT, F., Philippé, J., Speleman, F., et al. (1999). The αE-catenin gene (CTNNA1) acts as an invasion-suppressor gene in human colon cancer cells. ONCOGENE, 18(4), 905–915.
Vancouver
1.
Vermeulen S, Nollet F, TEUGELS E, VENNEKENS K, MALFAIT F, Philippé J, et al. The αE-catenin gene (CTNNA1) acts as an invasion-suppressor gene in human colon cancer cells. ONCOGENE. 1999;18(4):905–15.
MLA
Vermeulen, Stefan, Friedel Nollet, E TEUGELS, et al. “The αE-catenin Gene (CTNNA1) Acts as an Invasion-suppressor Gene in Human Colon Cancer Cells.” ONCOGENE 18.4 (1999): 905–915. Print.
@article{151537,
  abstract     = {The acquisition of invasiveness is a crucial step in the malignant progression of cancer. In cancers of the colon and of other organs the E-cadherin/catenin complex, which is implicated in homotypic cell-cell adhesion as well as in signal transduction, serves as a powerful inhibitor of invasion. We show here that one allele of the alpha E-catenin (CTNNA1) gene is mutated in the human colon cancer cell family HCT-8, which is identical to HCT-15, DLD-1 and HRT-18. Genetic instability, due to mutations in the HMSH6 (also called GTBP) mismatch repair gene, results in the spontaneous occurrence of invasive variants, all carrying either a mutation or exon skipping in the second alpha E-catenin allele, The alpha E-catenin gene is therefore, an invasion-suppressor gene in accordance with the two-hit model of Knudsen for tumour-suppressor genes.},
  author       = {Vermeulen, Stefan and Nollet, Friedel and TEUGELS, E and VENNEKENS, KM and MALFAIT, F and Philipp{\'e}, Jan and Speleman, Franki and Bracke, Marc and Van Roy, Frans and Mareel, Marcus},
  issn         = {0950-9232},
  journal      = {ONCOGENE},
  keyword      = {colon cancer,invasion,alpha E-catenin,genetic instability,NONPOLYPOSIS COLORECTAL-CARCINOMA,II RECEPTOR GENE,E-CADHERIN,MICROSATELLITE INSTABILITY,GROWTH-FACTOR,LYNCH SYNDROME,RETINOIC ACID,BETA-CATENIN,TUMOR-CELLS,MUTATIONS},
  language     = {eng},
  number       = {4},
  pages        = {905--915},
  title        = {The \ensuremath{\alpha}E-catenin gene (CTNNA1) acts as an invasion-suppressor gene in human colon cancer cells},
  url          = {http://dx.doi.org/10.1038/sj.onc.1202348},
  volume       = {18},
  year         = {1999},
}

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