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Stereologic characteristics of pig small intestine during normal development

Author
Organization
Abstract
Stereologic methods were used to study the behavior of the pig's intestinal wall during periods that are characterized by a high incidence of gastrointestinal disorders. For this purpose conventionally stained transverse and vertical paraffin sections were made of the small intestine (duodenum, jejunum, and ileum) of fetal, neonatal, and weaned pigs. The volumes of the intestinal walls were estimated using Cavalieri's method. Subsequently, the surface density (S-v) of the tunica mucosa and the volume densities (V-v) of the different small intestinal elements were estimated. Finally, the surface and volumes per serosal surface area (S-s and V-s) were calculated. The decrease of S-v can be attributed to the finding that the mucosal surface increases to a lesser extent compared with the volume of the intestinal wall. The V-s of the various layers increased postnatally, illustrating that the intestinal wall thickens. Despite an increasing total mucosal surface, this postnatal thickening causes S-s to decline. Each of these changes is temporally related to dietary changes, an increased antigen load, and an increased need for protection. Additionally, the regional differences of the various parameters match the qualitative descriptions of the small intestine of the pig and relate to region-specific functions.
Keywords
perinatal, weaning, pig, small intestine, stereology, MORPHOLOGY, AGE, DIET, RAT, ACID-SECRETION, VILLOUS HEIGHT, CRYPT DEPTH, GROWTH-FACTOR, EARLY-WEANED PIG, DIGESTIVE ENZYME-ACTIVITY

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Chicago
Van Ginneken, C, F Van Meir, Stanislas Sys, and A Weyns. 2002. “Stereologic Characteristics of Pig Small Intestine During Normal Development.” Digestive Diseases and Sciences 47 (4): 868–878.
APA
Van Ginneken, C., Van Meir, F., Sys, S., & Weyns, A. (2002). Stereologic characteristics of pig small intestine during normal development. DIGESTIVE DISEASES AND SCIENCES, 47(4), 868–878.
Vancouver
1.
Van Ginneken C, Van Meir F, Sys S, Weyns A. Stereologic characteristics of pig small intestine during normal development. DIGESTIVE DISEASES AND SCIENCES. 2002;47(4):868–78.
MLA
Van Ginneken, C, F Van Meir, Stanislas Sys, et al. “Stereologic Characteristics of Pig Small Intestine During Normal Development.” DIGESTIVE DISEASES AND SCIENCES 47.4 (2002): 868–878. Print.
@article{149312,
  abstract     = {Stereologic methods were used to study the behavior of the pig's intestinal wall during periods that are characterized by a high incidence of gastrointestinal disorders. For this purpose conventionally stained transverse and vertical paraffin sections were made of the small intestine (duodenum, jejunum, and ileum) of fetal, neonatal, and weaned pigs. The volumes of the intestinal walls were estimated using Cavalieri's method. Subsequently, the surface density (S-v) of the tunica mucosa and the volume densities (V-v) of the different small intestinal elements were estimated. Finally, the surface and volumes per serosal surface area (S-s and V-s) were calculated. The decrease of S-v can be attributed to the finding that the mucosal surface increases to a lesser extent compared with the volume of the intestinal wall. The V-s of the various layers increased postnatally, illustrating that the intestinal wall thickens. Despite an increasing total mucosal surface, this postnatal thickening causes S-s to decline. Each of these changes is temporally related to dietary changes, an increased antigen load, and an increased need for protection. Additionally, the regional differences of the various parameters match the qualitative descriptions of the small intestine of the pig and relate to region-specific functions.},
  articleno    = {UNSP 0163-2116/02/0400-0868/0},
  author       = {Van Ginneken, C and Van Meir, F and Sys, Stanislas and Weyns, A},
  issn         = {0163-2116},
  journal      = {DIGESTIVE DISEASES AND SCIENCES},
  keyword      = {perinatal,weaning,pig,small intestine,stereology,MORPHOLOGY,AGE,DIET,RAT,ACID-SECRETION,VILLOUS HEIGHT,CRYPT DEPTH,GROWTH-FACTOR,EARLY-WEANED PIG,DIGESTIVE ENZYME-ACTIVITY},
  language     = {eng},
  number       = {4},
  pages        = {UNSP 0163-2116/02/0400-0868/0:868--UNSP 0163-2116/02/0400-0868/0:878},
  title        = {Stereologic characteristics of pig small intestine during normal development},
  volume       = {47},
  year         = {2002},
}

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