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8-Prenylnaringenin, the phytoestrogen in hops and beer, upregulates the function of the E-cadherin/catenin complex in human mammary carcinoma cells

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Abstract
The E-cadherin/catenin complex is a powerful invasion suppressor in epithelial cells. It is expressed in the human MCF-7 breast cancer cell line family, but functionally defective in the invasive MCF-7/6 variant. Previous experiments have shown that IGF-I, tamoxifen, retinoic acid and tangeretin are able to upregulate the function of this complex in MCF-7/6 cells. We investigated the effect of 8-prenylnaringenin (8-PN), the phytoestrogen present in hops and beer, on aggregation, growth and invasion in MCF-7/6 cells. 8-PN was found to stimulate E-cadherin-dependent aggregation and growth of MCF-7/6 cells in suspension. These effects could be inhibited by the pure antiestrogen ICI 182,780.8-PN did not affect invasion of MCF-7/6 cells in the chick heart assay in vitro. In all these aspects 8-PN mimics the effects of 17 beta -estradiol on MCF-7/6 cells.
Keywords
EXPRESSION, INHIBITION, GROWTH, INVITRO, INVASION, BREAST-CANCER, phytoestrogens, MCF-7, E-cadherin/catenin, 8-prenylnaringenin, MEMBRANE, MOTILITY, CULTURES, ADHESION

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MLA
Rong, Haojing, Tom Boterberg, Julie Maubach, et al. “8-Prenylnaringenin, the Phytoestrogen in Hops and Beer, Upregulates the Function of the E-cadherin/catenin Complex in Human Mammary Carcinoma Cells.” EUROPEAN JOURNAL OF CELL BIOLOGY 80.9 (2001): 580–585. Print.
APA
Rong, H., Boterberg, T., Maubach, J., Stove, C., Depypere, H., Van Slambrouck, S., Serreyn, R., et al. (2001). 8-Prenylnaringenin, the phytoestrogen in hops and beer, upregulates the function of the E-cadherin/catenin complex in human mammary carcinoma cells. EUROPEAN JOURNAL OF CELL BIOLOGY, 80(9), 580–585.
Chicago author-date
Rong, Haojing, Tom Boterberg, Julie Maubach, Christophe Stove, Herman Depypere, Séverine Van Slambrouck, Rudolphe Serreyn, Denis De Keukeleire, Marcus Mareel, and Marc Bracke. 2001. “8-Prenylnaringenin, the Phytoestrogen in Hops and Beer, Upregulates the Function of the E-cadherin/catenin Complex in Human Mammary Carcinoma Cells.” European Journal of Cell Biology 80 (9): 580–585.
Chicago author-date (all authors)
Rong, Haojing, Tom Boterberg, Julie Maubach, Christophe Stove, Herman Depypere, Séverine Van Slambrouck, Rudolphe Serreyn, Denis De Keukeleire, Marcus Mareel, and Marc Bracke. 2001. “8-Prenylnaringenin, the Phytoestrogen in Hops and Beer, Upregulates the Function of the E-cadherin/catenin Complex in Human Mammary Carcinoma Cells.” European Journal of Cell Biology 80 (9): 580–585.
Vancouver
1.
Rong H, Boterberg T, Maubach J, Stove C, Depypere H, Van Slambrouck S, et al. 8-Prenylnaringenin, the phytoestrogen in hops and beer, upregulates the function of the E-cadherin/catenin complex in human mammary carcinoma cells. EUROPEAN JOURNAL OF CELL BIOLOGY. 2001;80(9):580–5.
IEEE
[1]
H. Rong et al., “8-Prenylnaringenin, the phytoestrogen in hops and beer, upregulates the function of the E-cadherin/catenin complex in human mammary carcinoma cells,” EUROPEAN JOURNAL OF CELL BIOLOGY, vol. 80, no. 9, pp. 580–585, 2001.
@article{148553,
  abstract     = {The E-cadherin/catenin complex is a powerful invasion suppressor in epithelial cells. It is expressed in the human MCF-7 breast cancer cell line family, but functionally defective in the invasive MCF-7/6 variant. Previous experiments have shown that IGF-I, tamoxifen, retinoic acid and tangeretin are able to upregulate the function of this complex in MCF-7/6 cells. We investigated the effect of 8-prenylnaringenin (8-PN), the phytoestrogen present in hops and beer, on aggregation, growth and invasion in MCF-7/6 cells. 8-PN was found to stimulate E-cadherin-dependent aggregation and growth of MCF-7/6 cells in suspension. These effects could be inhibited by the pure antiestrogen ICI 182,780.8-PN did not affect invasion of MCF-7/6 cells in the chick heart assay in vitro. In all these aspects 8-PN mimics the effects of 17 beta -estradiol on MCF-7/6 cells.},
  author       = {Rong, Haojing and Boterberg, Tom and Maubach, Julie and Stove, Christophe and Depypere, Herman and Van Slambrouck, Séverine and Serreyn, Rudolphe and De Keukeleire, Denis and Mareel, Marcus and Bracke, Marc},
  issn         = {0171-9335},
  journal      = {EUROPEAN JOURNAL OF CELL BIOLOGY},
  keywords     = {EXPRESSION,INHIBITION,GROWTH,INVITRO,INVASION,BREAST-CANCER,phytoestrogens,MCF-7,E-cadherin/catenin,8-prenylnaringenin,MEMBRANE,MOTILITY,CULTURES,ADHESION},
  language     = {eng},
  number       = {9},
  pages        = {580--585},
  title        = {8-Prenylnaringenin, the phytoestrogen in hops and beer, upregulates the function of the E-cadherin/catenin complex in human mammary carcinoma cells},
  url          = {http://dx.doi.org/10.1078/0171-9335-00190},
  volume       = {80},
  year         = {2001},
}

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