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8-Prenylnaringenin, the phytoestrogen in hops and beer, upregulates the function of the E-cadherin/catenin complex in human mammary carcinoma cells

Haojing Rong, Tom Boterberg UGent, Julie Maubach, Christophe Stove UGent, Herman Depypere UGent, Séverine Van Slambrouck UGent, Rudolphe Serreyn, Denis De Keukeleire, MARCUS MAREEL and Marc Bracke UGent (2001) EUROPEAN JOURNAL OF CELL BIOLOGY. 80(9). p.580-585
abstract
The E-cadherin/catenin complex is a powerful invasion suppressor in epithelial cells. It is expressed in the human MCF-7 breast cancer cell line family, but functionally defective in the invasive MCF-7/6 variant. Previous experiments have shown that IGF-I, tamoxifen, retinoic acid and tangeretin are able to upregulate the function of this complex in MCF-7/6 cells. We investigated the effect of 8-prenylnaringenin (8-PN), the phytoestrogen present in hops and beer, on aggregation, growth and invasion in MCF-7/6 cells. 8-PN was found to stimulate E-cadherin-dependent aggregation and growth of MCF-7/6 cells in suspension. These effects could be inhibited by the pure antiestrogen ICI 182,780.8-PN did not affect invasion of MCF-7/6 cells in the chick heart assay in vitro. In all these aspects 8-PN mimics the effects of 17 beta -estradiol on MCF-7/6 cells.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
EXPRESSION, INHIBITION, GROWTH, INVITRO, INVASION, BREAST-CANCER, phytoestrogens, MCF-7, E-cadherin/catenin, 8-prenylnaringenin, MEMBRANE, MOTILITY, CULTURES, ADHESION
journal title
EUROPEAN JOURNAL OF CELL BIOLOGY
Eur. J. Cell Biol.
volume
80
issue
9
pages
580 - 585
Web of Science type
Article
Web of Science id
000171723300002
JCR category
CELL BIOLOGY
JCR impact factor
2.244 (2001)
JCR rank
70/146 (2001)
JCR quartile
2 (2001)
ISSN
0171-9335
DOI
10.1078/0171-9335-00190
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
148553
handle
http://hdl.handle.net/1854/LU-148553
date created
2004-01-14 13:38:00
date last changed
2016-12-19 15:38:32
@article{148553,
  abstract     = {The E-cadherin/catenin complex is a powerful invasion suppressor in epithelial cells. It is expressed in the human MCF-7 breast cancer cell line family, but functionally defective in the invasive MCF-7/6 variant. Previous experiments have shown that IGF-I, tamoxifen, retinoic acid and tangeretin are able to upregulate the function of this complex in MCF-7/6 cells. We investigated the effect of 8-prenylnaringenin (8-PN), the phytoestrogen present in hops and beer, on aggregation, growth and invasion in MCF-7/6 cells. 8-PN was found to stimulate E-cadherin-dependent aggregation and growth of MCF-7/6 cells in suspension. These effects could be inhibited by the pure antiestrogen ICI 182,780.8-PN did not affect invasion of MCF-7/6 cells in the chick heart assay in vitro. In all these aspects 8-PN mimics the effects of 17 beta -estradiol on MCF-7/6 cells.},
  author       = {Rong, Haojing and Boterberg, Tom and Maubach, Julie and Stove, Christophe and Depypere, Herman and Van Slambrouck, S{\'e}verine and Serreyn, Rudolphe and De Keukeleire, Denis and MAREEL, MARCUS and Bracke, Marc},
  issn         = {0171-9335},
  journal      = {EUROPEAN JOURNAL OF CELL BIOLOGY},
  keyword      = {EXPRESSION,INHIBITION,GROWTH,INVITRO,INVASION,BREAST-CANCER,phytoestrogens,MCF-7,E-cadherin/catenin,8-prenylnaringenin,MEMBRANE,MOTILITY,CULTURES,ADHESION},
  language     = {eng},
  number       = {9},
  pages        = {580--585},
  title        = {8-Prenylnaringenin, the phytoestrogen in hops and beer, upregulates the function of the E-cadherin/catenin complex in human mammary carcinoma cells},
  url          = {http://dx.doi.org/10.1078/0171-9335-00190},
  volume       = {80},
  year         = {2001},
}

Chicago
Rong, Haojing, Tom Boterberg, Julie Maubach, Christophe Stove, Herman Depypere, Séverine Van Slambrouck, Rudolphe Serreyn, Denis De Keukeleire, MARCUS MAREEL, and Marc Bracke. 2001. “8-Prenylnaringenin, the Phytoestrogen in Hops and Beer, Upregulates the Function of the E-cadherin/catenin Complex in Human Mammary Carcinoma Cells.” European Journal of Cell Biology 80 (9): 580–585.
APA
Rong, H., Boterberg, T., Maubach, J., Stove, C., Depypere, H., Van Slambrouck, S., Serreyn, R., et al. (2001). 8-Prenylnaringenin, the phytoestrogen in hops and beer, upregulates the function of the E-cadherin/catenin complex in human mammary carcinoma cells. EUROPEAN JOURNAL OF CELL BIOLOGY, 80(9), 580–585.
Vancouver
1.
Rong H, Boterberg T, Maubach J, Stove C, Depypere H, Van Slambrouck S, et al. 8-Prenylnaringenin, the phytoestrogen in hops and beer, upregulates the function of the E-cadherin/catenin complex in human mammary carcinoma cells. EUROPEAN JOURNAL OF CELL BIOLOGY. 2001;80(9):580–5.
MLA
Rong, Haojing, Tom Boterberg, Julie Maubach, et al. “8-Prenylnaringenin, the Phytoestrogen in Hops and Beer, Upregulates the Function of the E-cadherin/catenin Complex in Human Mammary Carcinoma Cells.” EUROPEAN JOURNAL OF CELL BIOLOGY 80.9 (2001): 580–585. Print.