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8-Prenylnaringenin, the phytoestrogen in hops and beer, upregulates the function of the E-cadherin/catenin complex in human mammary carcinoma cells

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Abstract
The E-cadherin/catenin complex is a powerful invasion suppressor in epithelial cells. It is expressed in the human MCF-7 breast cancer cell line family, but functionally defective in the invasive MCF-7/6 variant. Previous experiments have shown that IGF-I, tamoxifen, retinoic acid and tangeretin are able to upregulate the function of this complex in MCF-7/6 cells. We investigated the effect of 8-prenylnaringenin (8-PN), the phytoestrogen present in hops and beer, on aggregation, growth and invasion in MCF-7/6 cells. 8-PN was found to stimulate E-cadherin-dependent aggregation and growth of MCF-7/6 cells in suspension. These effects could be inhibited by the pure antiestrogen ICI 182,780.8-PN did not affect invasion of MCF-7/6 cells in the chick heart assay in vitro. In all these aspects 8-PN mimics the effects of 17 beta -estradiol on MCF-7/6 cells.
Keywords
EXPRESSION, INHIBITION, GROWTH, INVITRO, INVASION, BREAST-CANCER, phytoestrogens, MCF-7, E-cadherin/catenin, 8-prenylnaringenin, MEMBRANE, MOTILITY, CULTURES, ADHESION

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Chicago
Rong, Haojing, Tom Boterberg, Julie Maubach, Christophe Stove, Herman Depypere, Séverine Van Slambrouck, Rudolphe Serreyn, Denis De Keukeleire, Marcus Mareel, and Marc Bracke. 2001. “8-Prenylnaringenin, the Phytoestrogen in Hops and Beer, Upregulates the Function of the E-cadherin/catenin Complex in Human Mammary Carcinoma Cells.” European Journal of Cell Biology 80 (9): 580–585.
APA
Rong, H., Boterberg, T., Maubach, J., Stove, C., Depypere, H., Van Slambrouck, S., Serreyn, R., et al. (2001). 8-Prenylnaringenin, the phytoestrogen in hops and beer, upregulates the function of the E-cadherin/catenin complex in human mammary carcinoma cells. EUROPEAN JOURNAL OF CELL BIOLOGY, 80(9), 580–585.
Vancouver
1.
Rong H, Boterberg T, Maubach J, Stove C, Depypere H, Van Slambrouck S, et al. 8-Prenylnaringenin, the phytoestrogen in hops and beer, upregulates the function of the E-cadherin/catenin complex in human mammary carcinoma cells. EUROPEAN JOURNAL OF CELL BIOLOGY. 2001;80(9):580–5.
MLA
Rong, Haojing, Tom Boterberg, Julie Maubach, et al. “8-Prenylnaringenin, the Phytoestrogen in Hops and Beer, Upregulates the Function of the E-cadherin/catenin Complex in Human Mammary Carcinoma Cells.” EUROPEAN JOURNAL OF CELL BIOLOGY 80.9 (2001): 580–585. Print.
@article{148553,
  abstract     = {The E-cadherin/catenin complex is a powerful invasion suppressor in epithelial cells. It is expressed in the human MCF-7 breast cancer cell line family, but functionally defective in the invasive MCF-7/6 variant. Previous experiments have shown that IGF-I, tamoxifen, retinoic acid and tangeretin are able to upregulate the function of this complex in MCF-7/6 cells. We investigated the effect of 8-prenylnaringenin (8-PN), the phytoestrogen present in hops and beer, on aggregation, growth and invasion in MCF-7/6 cells. 8-PN was found to stimulate E-cadherin-dependent aggregation and growth of MCF-7/6 cells in suspension. These effects could be inhibited by the pure antiestrogen ICI 182,780.8-PN did not affect invasion of MCF-7/6 cells in the chick heart assay in vitro. In all these aspects 8-PN mimics the effects of 17 beta -estradiol on MCF-7/6 cells.},
  author       = {Rong, Haojing and Boterberg, Tom and Maubach, Julie and Stove, Christophe and Depypere, Herman and Van Slambrouck, S{\'e}verine and Serreyn, Rudolphe and De Keukeleire, Denis and Mareel, Marcus and Bracke, Marc},
  issn         = {0171-9335},
  journal      = {EUROPEAN JOURNAL OF CELL BIOLOGY},
  keyword      = {EXPRESSION,INHIBITION,GROWTH,INVITRO,INVASION,BREAST-CANCER,phytoestrogens,MCF-7,E-cadherin/catenin,8-prenylnaringenin,MEMBRANE,MOTILITY,CULTURES,ADHESION},
  language     = {eng},
  number       = {9},
  pages        = {580--585},
  title        = {8-Prenylnaringenin, the phytoestrogen in hops and beer, upregulates the function of the E-cadherin/catenin complex in human mammary carcinoma cells},
  url          = {http://dx.doi.org/10.1078/0171-9335-00190},
  volume       = {80},
  year         = {2001},
}

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