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Regional brain perfusion in 10 normal dogs measured using technetium-99m ethyl cysteinate dimer SPECT

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Abstract
Single photon emission computed tomography (SPECT) of the brain using perfusion tracers allows estimation of regional brain perfusion. This allows in vivo examination of brain function in the setting or neuropsychologic and pathophysiologic changes. However functional imaging data on brain perfusion in dogs are limited. Hence, the aim of this study was to determine the scintigraphic regional perfusion pattern of the normal canine brain. Ten healthy shepherd type dogs were injected with 925 MBq Technetium-99m ethyl cysteinate (ECD) 20 minutes before the examination. Acquisition was performed using a triple head gamma camera equipped with fanbeam collimators. Uniform attenuation correction and triple energy window correction were applied. Computed tomographic images were obtained from the same dogs, reoriented along the orbito-meatal axis and SPECT perfusion data were coregistered to the CT-volume data. Based on morphological and suggested brain divisions, regions-of-interest (ROIs) were defined for the bilateral frontocerebral, temporocerebral, parietocerebral, occipitocerebral, cerebellar, thalamic, and striatal area. Regional count density was normalized on total counts. All dogs had the highest uptake in the thalamic/striatal area compared to a rather homogeneous cerebral uptake. No significant left/right count differences were found, but a rostro-caudal gradient (+12-13%) was present. In this group, age and gender did not influence the perfusion pattern.
Keywords
scintigraphy, dog, brain perfusion, technetium-99m ethyl cysteinate dimer, CEREBRAL BLOOD-FLOW, METABOLISM, PATTERN

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Chicago
Peremans, Kathelijne, P De Bondt, Kurt Audenaert, Koenraad Van Laere, Ingrid Gielen, Michel Koole, JAN VERSIJPT, Henri van Bree, Francis Verschooten, and Rudi Dierckx. 2001. “Regional Brain Perfusion in 10 Normal Dogs Measured Using Technetium-99m Ethyl Cysteinate Dimer SPECT.” Veterinary Radiology & Ultrasound 42 (6): 562–568.
APA
Peremans, K., De Bondt, P., Audenaert, K., Van Laere, K., Gielen, I., Koole, M., VERSIJPT, J., et al. (2001). Regional brain perfusion in 10 normal dogs measured using technetium-99m ethyl cysteinate dimer SPECT. VETERINARY RADIOLOGY & ULTRASOUND, 42(6), 562–568.
Vancouver
1.
Peremans K, De Bondt P, Audenaert K, Van Laere K, Gielen I, Koole M, et al. Regional brain perfusion in 10 normal dogs measured using technetium-99m ethyl cysteinate dimer SPECT. VETERINARY RADIOLOGY & ULTRASOUND. 2001;42(6):562–8.
MLA
Peremans, Kathelijne, P De Bondt, Kurt Audenaert, et al. “Regional Brain Perfusion in 10 Normal Dogs Measured Using Technetium-99m Ethyl Cysteinate Dimer SPECT.” VETERINARY RADIOLOGY & ULTRASOUND 42.6 (2001): 562–568. Print.
@article{146451,
  abstract     = {Single photon emission computed tomography (SPECT) of the brain using perfusion tracers allows estimation of regional brain perfusion. This allows in vivo examination of brain function in the setting or neuropsychologic and pathophysiologic changes. However functional imaging data on brain perfusion in dogs are limited. Hence, the aim of this study was to determine the scintigraphic regional perfusion pattern of the normal canine brain. Ten healthy shepherd type dogs were injected with 925 MBq Technetium-99m ethyl cysteinate (ECD) 20 minutes before the examination. Acquisition was performed using a triple head gamma camera equipped with fanbeam collimators. Uniform attenuation correction and triple energy window correction were applied. Computed tomographic images were obtained from the same dogs, reoriented along the orbito-meatal axis and SPECT perfusion data were coregistered to the CT-volume data. Based on morphological and suggested brain divisions, regions-of-interest (ROIs) were defined for the bilateral frontocerebral, temporocerebral, parietocerebral, occipitocerebral, cerebellar, thalamic, and striatal area. Regional count density was normalized on total counts. All dogs had the highest uptake in the thalamic/striatal area compared to a rather homogeneous cerebral uptake. No significant left/right count differences were found, but a rostro-caudal gradient (+12-13\%) was present. In this group, age and gender did not influence the perfusion pattern.},
  author       = {Peremans, Kathelijne and De Bondt, P and Audenaert, Kurt and Van Laere, Koenraad and Gielen, Ingrid and Koole, Michel and VERSIJPT, JAN and van Bree, Henri and Verschooten, Francis and Dierckx, Rudi},
  issn         = {1058-8183},
  journal      = {VETERINARY RADIOLOGY \& ULTRASOUND},
  keyword      = {scintigraphy,dog,brain perfusion,technetium-99m ethyl cysteinate dimer,CEREBRAL BLOOD-FLOW,METABOLISM,PATTERN},
  language     = {eng},
  number       = {6},
  pages        = {562--568},
  title        = {Regional brain perfusion in 10 normal dogs measured using technetium-99m ethyl cysteinate dimer SPECT},
  url          = {http://dx.doi.org/10.1111/j.1740-8261.2001.tb00987.x},
  volume       = {42},
  year         = {2001},
}

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