Advanced search
1 file | 322.76 KB Add to list

Transfer of normal 99mTc-ECD brain SPET databases between different gamma cameras

Author
Organization
Abstract
A stereotactic, normal perfusion database is imperative for optimal clinical brain single-photon emission tomography (SPET). However, interdepartmental use of normal data necessitates accurate transferability of these data sets. The aim of this study was to investigate transfer of three normal perfusion databases obtained in the same large population of healthy volunteers who underwent sequential scanning using multihead gamma cameras with different resolution. Eighty-nine healthy adults (46 females, 43 males; aged 20-81 years) were thoroughly screened by history, biochemistry, physical and full neurological examination, neuropsychological testing and magnetic resonance imaging. After injection of 925 MBq technetium-99m labelled ethyl cysteinate dimer (ECD) under standard conditions, 101 scans were acquired from all subjects (12 repeat studies) on a triple-head Toshiba GCA-9300A (measured average FWHM 8.1 mm). Ninety-one sequential scans were performed on a dual-head Elscint Helix camera (FWHM 9.6 mm) and 22 subjects also underwent imaging on a triple-head Prism 3000 (FWHM 9.6 mm). Images were transferred to the same processing platform and reconstructed by filtered back-projection with the same Butterworth filter (order 8, cut-off 0.9 cycles/cm) and uniform Sorensen attenuation correction (mu =0.09). After automated rigid intrasubject registration, all subjects were automatically reoriented to a stereotactic template by a nine-parameter affine transformation. The databases were analysed using 35 predefined volumes of interest (VOIs) with normalisation on total VOI counts. For comparison, the high-resolution data were smoothed with a 3D Gaussian kernel to achieve moro similar spatial resolution. Hoffman phantom measurements were conducted on all cameras. Partial volume effects after smoothing varied between -6.5% and 10%, depending on VOI size. Between-camera reproducibility was 2.5% and 2.7% for the Toshiba camera versus the Helix and the Prism database, respectively. The highest reduction in between-camera variability was achieved by resolution adjustment in combination with linear washout correction and a Hoffman phantom-based correction. In conclusion, transfer of normal perfusion data between multihead gamma cameras can be accurately achieved, thereby enabling widespread interdepartmental use, which is likely to have a positive impact on the diagnostic capabilities of clinical brain perfusion SPET.
Keywords
PERFUSION, QUANTIFICATION, TECHNETIUM-99M-ECD, TC-99M-HMPAO, PERFORMANCE, ASYMMETRIES, EMISSION, IMAGES, regional cerebral blood flow, Tc-99m-ECD, normal database, resolution, CEREBRAL BLOOD-FLOW, AGE-RELATED-CHANGES

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 322.76 KB

Citation

Please use this url to cite or link to this publication:

MLA
Van Laere, Koenraad, et al. “Transfer of Normal 99mTc-ECD Brain SPET Databases between Different Gamma Cameras.” EUROPEAN JOURNAL OF NUCLEAR MEDICINE, vol. 28, no. 4, 2001, pp. 435–49, doi:10.1007/s002590000461.
APA
Van Laere, K., Koole, M., VERSIJPT, J., Vandenberghe, S., Brans, B., D’Asseler, Y., … Dierckx, R. (2001). Transfer of normal 99mTc-ECD brain SPET databases between different gamma cameras. EUROPEAN JOURNAL OF NUCLEAR MEDICINE, 28(4), 435–449. https://doi.org/10.1007/s002590000461
Chicago author-date
Van Laere, Koenraad, Michel Koole, JAN VERSIJPT, Stefaan Vandenberghe, Boudewijn Brans, Yves D’Asseler, Olivier De Winter, Alain Kalmar, and Rudi Dierckx. 2001. “Transfer of Normal 99mTc-ECD Brain SPET Databases between Different Gamma Cameras.” EUROPEAN JOURNAL OF NUCLEAR MEDICINE 28 (4): 435–49. https://doi.org/10.1007/s002590000461.
Chicago author-date (all authors)
Van Laere, Koenraad, Michel Koole, JAN VERSIJPT, Stefaan Vandenberghe, Boudewijn Brans, Yves D’Asseler, Olivier De Winter, Alain Kalmar, and Rudi Dierckx. 2001. “Transfer of Normal 99mTc-ECD Brain SPET Databases between Different Gamma Cameras.” EUROPEAN JOURNAL OF NUCLEAR MEDICINE 28 (4): 435–449. doi:10.1007/s002590000461.
Vancouver
1.
Van Laere K, Koole M, VERSIJPT J, Vandenberghe S, Brans B, D’Asseler Y, et al. Transfer of normal 99mTc-ECD brain SPET databases between different gamma cameras. EUROPEAN JOURNAL OF NUCLEAR MEDICINE. 2001;28(4):435–49.
IEEE
[1]
K. Van Laere et al., “Transfer of normal 99mTc-ECD brain SPET databases between different gamma cameras,” EUROPEAN JOURNAL OF NUCLEAR MEDICINE, vol. 28, no. 4, pp. 435–449, 2001.
@article{144336,
  abstract     = {{A stereotactic, normal perfusion database is imperative for optimal clinical brain single-photon emission tomography (SPET). However, interdepartmental use of normal data necessitates accurate transferability of these data sets. The aim of this study was to investigate transfer of three normal perfusion databases obtained in the same large population of healthy volunteers who underwent sequential scanning using multihead gamma cameras with different resolution. Eighty-nine healthy adults (46 females, 43 males; aged 20-81 years) were thoroughly screened by history, biochemistry, physical and full neurological examination, neuropsychological testing and magnetic resonance imaging. After injection of 925 MBq technetium-99m labelled ethyl cysteinate dimer (ECD) under standard conditions, 101 scans were acquired from all subjects (12 repeat studies) on a triple-head Toshiba GCA-9300A (measured average FWHM 8.1 mm). Ninety-one sequential scans were performed on a dual-head Elscint Helix camera (FWHM 9.6 mm) and 22 subjects also underwent imaging on a triple-head Prism 3000 (FWHM 9.6 mm). Images were transferred to the same processing platform and reconstructed by filtered back-projection with the same Butterworth filter (order 8, cut-off 0.9 cycles/cm) and uniform Sorensen attenuation correction (mu =0.09). After automated rigid intrasubject registration, all subjects were automatically reoriented to a stereotactic template by a nine-parameter affine transformation. The databases were analysed using 35 predefined volumes of interest (VOIs) with normalisation on total VOI counts. For comparison, the high-resolution data were smoothed with a 3D Gaussian kernel to achieve moro similar spatial resolution. Hoffman phantom measurements were conducted on all cameras. Partial volume effects after smoothing varied between -6.5% and 10%, depending on VOI size. Between-camera reproducibility was 2.5% and 2.7% for the Toshiba camera versus the Helix and the Prism database, respectively. The highest reduction in between-camera variability was achieved by resolution adjustment in combination with linear washout correction and a Hoffman phantom-based correction. In conclusion, transfer of normal perfusion data between multihead gamma cameras can be accurately achieved, thereby enabling widespread interdepartmental use, which is likely to have a positive impact on the diagnostic capabilities of clinical brain perfusion SPET.}},
  author       = {{Van Laere, Koenraad and Koole, Michel and VERSIJPT, JAN and Vandenberghe, Stefaan and Brans, Boudewijn and D'Asseler, Yves and De Winter, Olivier and Kalmar, Alain and Dierckx, Rudi}},
  issn         = {{0340-6997}},
  journal      = {{EUROPEAN JOURNAL OF NUCLEAR MEDICINE}},
  keywords     = {{PERFUSION,QUANTIFICATION,TECHNETIUM-99M-ECD,TC-99M-HMPAO,PERFORMANCE,ASYMMETRIES,EMISSION,IMAGES,regional cerebral blood flow,Tc-99m-ECD,normal database,resolution,CEREBRAL BLOOD-FLOW,AGE-RELATED-CHANGES}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{435--449}},
  title        = {{Transfer of normal 99mTc-ECD brain SPET databases between different gamma cameras}},
  url          = {{http://doi.org/10.1007/s002590000461}},
  volume       = {{28}},
  year         = {{2001}},
}

Altmetric
View in Altmetric
Web of Science
Times cited: