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Ocular manifestations of infection with the human immunodeficiency virus in an African pediatric population

Philippe Kestelyn, P Lepage, E Karita and P Van de Perre (2000) OCULAR IMMUNOLOGY AND INFLAMMATION. 8(4). p.263-273
abstract
Purpose: To describe the ocular manifestations of HIV/AIDS infection in an African pediatric population. Methods: From 1984 to 1990, all children with HIV infection attending the Department of Pediatrics of the 'Centre Hospitalier de Kigali', Rwanda, were referred to the Department of Ophthalmology for ophthalmic examination. Results: A total of 162 HIV-infected children were examined. The overall rate of ophthalmic involvement was 54%. The most common finding was a perivasculitis of the peripheral retinal vessels, observed in 38% of the patients. Cytomegalovirus (CMV) infection of the retina was diagnosed in three patients. Isolated cotton-wool spots of the retina were not observed. Ophthalmic herpes zoster and conjunctival xerosis responding to vitamin A administration were each seen in two patients. One third of a subset of children tested for lacrimal function had evidence of decreased tear secretion. Conclusion: Our data, in agreement with other series reported in the literature, indicate that cotton-wool spots and CMV retinitis, the most common ocular manifestations of HIV/AIDS in adults, are much less prevalent in children. The high incidence of perivasculitis in the present series, not observed or only seen in a few cases in other series, suggests that this ocular sign is more prevalent in African children. Our working hypothesis is that perivasculitis of the retinal vessels, lymphoid interstitial pneumonitis, parotitis, and lacrimal gland involvement are the expression of a diffuse infiltrative lymphocytosis syndrome, similar to what has been described in adults.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (proceedingsPaper)
publication status
published
subject
keyword
HIV, eye, children, Africa, AIDS-RELATED COMPLEX, CHILDREN, HIV, DISEASE
journal title
OCULAR IMMUNOLOGY AND INFLAMMATION
Ocul. Immunol. Inflamm.
volume
8
issue
4
pages
263 - 273
conference name
Annaul meeting of the Society for Ocular Immunoinfectiology (SOIE 2000)
conference location
Paris, France
conference start
2000-03-17
conference end
2000-03-19
Web of Science type
Article; Proceedings Paper
Web of Science id
000166592700007
ISSN
0927-3948
DOI
10.1076/ocii.8.4.263.6455
language
English
UGent publication?
yes
classification
A1
id
142719
handle
http://hdl.handle.net/1854/LU-142719
date created
2004-01-14 13:37:00
date last changed
2017-06-16 13:27:20
@article{142719,
  abstract     = {Purpose: To describe the ocular manifestations of HIV/AIDS infection in an African pediatric population.
Methods: From 1984 to 1990, all children with HIV infection attending the Department of Pediatrics of the 'Centre Hospitalier de Kigali', Rwanda, were referred to the Department of Ophthalmology for ophthalmic examination.
Results: A total of 162 HIV-infected children were examined. The overall rate of ophthalmic involvement was 54\%. The most common finding was a perivasculitis of the peripheral retinal vessels, observed in 38\% of the patients. Cytomegalovirus (CMV) infection of the retina was diagnosed in three patients. Isolated cotton-wool spots of the retina were not observed. Ophthalmic herpes zoster and conjunctival xerosis responding to vitamin A administration were each seen in two patients. One third of a subset of children tested for lacrimal function had evidence of decreased tear secretion.
Conclusion: Our data, in agreement with other series reported in the literature, indicate that cotton-wool spots and CMV retinitis, the most common ocular manifestations of HIV/AIDS in adults, are much less prevalent in children. The high incidence of perivasculitis in the present series, not observed or only seen in a few cases in other series, suggests that this ocular sign is more prevalent in African children. Our working hypothesis is that perivasculitis of the retinal vessels, lymphoid interstitial pneumonitis, parotitis, and lacrimal gland involvement are the expression of a diffuse infiltrative lymphocytosis syndrome, similar to what has been described in adults.},
  author       = {Kestelyn, Philippe and Lepage, P and Karita, E and Van de Perre, P},
  issn         = {0927-3948},
  journal      = {OCULAR IMMUNOLOGY AND INFLAMMATION},
  keyword      = {HIV,eye,children,Africa,AIDS-RELATED COMPLEX,CHILDREN,HIV,DISEASE},
  language     = {eng},
  location     = {Paris, France},
  number       = {4},
  pages        = {263--273},
  title        = {Ocular manifestations of infection with the human immunodeficiency virus in an African pediatric population},
  url          = {http://dx.doi.org/10.1076/ocii.8.4.263.6455},
  volume       = {8},
  year         = {2000},
}

Chicago
Kestelyn, Philippe, P Lepage, E Karita, and P Van de Perre. 2000. “Ocular Manifestations of Infection with the Human Immunodeficiency Virus in an African Pediatric Population.” Ocular Immunology and Inflammation 8 (4): 263–273.
APA
Kestelyn, P., Lepage, P., Karita, E., & Van de Perre, P. (2000). Ocular manifestations of infection with the human immunodeficiency virus in an African pediatric population. OCULAR IMMUNOLOGY AND INFLAMMATION, 8(4), 263–273. Presented at the Annaul meeting of the Society for Ocular Immunoinfectiology (SOIE 2000) .
Vancouver
1.
Kestelyn P, Lepage P, Karita E, Van de Perre P. Ocular manifestations of infection with the human immunodeficiency virus in an African pediatric population. OCULAR IMMUNOLOGY AND INFLAMMATION. 2000;8(4):263–73.
MLA
Kestelyn, Philippe, P Lepage, E Karita, et al. “Ocular Manifestations of Infection with the Human Immunodeficiency Virus in an African Pediatric Population.” OCULAR IMMUNOLOGY AND INFLAMMATION 8.4 (2000): 263–273. Print.