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99mTc-ECD brain perfusion SPET: variability, asymmetry and effects of age and gender in healthy adults

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Abstract
Reliable and high-resolution reference data for regional cerebral blood flow measured with single-photon emission tomography (SPET) are necessary for optimal clinical and research use. Therefore, a large dataset of normal technetium-99m labelled ethylene cysteine dimer (ECD) perfusion SPET in carefully screened healthy volunteers with an age range spanning six decades was created, with correction for non-uniform attenuation and scatter and based on an anatomically standardised analysis. Eighty-nine healthy volunteers, stratified for gender (46 females, 43 males; age 20-81 years), were included. Twelve volunteers underwent repeated Tc-99m-ECD SPET after 2.5 +/-2.3 weeks. An automated whole-brain volume of interest analysis with MANOVA as well as voxelwise analysis using SPM99 was conducted. Average intersubject variability was 4.8% while intrasubject reproducibility was 3.0%. An age-related decline in tracer uptake was found in the anterior cingulate gyrus, bilateral basal ganglia, left prefrontal, left lateral frontal and left superior temporal and insular cortex (all P=0.001-0.02). There was an overall increase in right/left asymmetry with age, which was most pronounced in the frontal and temporal neocortex. The most significant correlations between AI and age decade were found in the prefrontal (R=0.35, P=0.001) and superior temporal neocortex (R=0.43, P <0.001). Women had significantly higher uptake in the right parietal cortex (P <0.001), while men showed higher uptake in the cerebellum and the left anterior temporal and orbitofrontal cortex (all P <0.01). This normative dataset allows age- and gender-specific patient and group assessment of Tc-99m-ECD per fusion SPET under a wide variety of clinical circumstances in relation to normal variations and highlights the importance of both age- and gender-specific normal datasets for optimal analysis sensitivity.
Keywords
TECHNETIUM-99M-HMPAO, cerebral blood flow, DEMENTIA, FDG-PET, RESTING STATE, NORMAL PATTERNS, SEX-DIFFERENCES, ALZHEIMERS-DISEASE, HEXAMETHYLPROPYLENE AMINE OXIME, CEREBRAL BLOOD-FLOW, POSITRON-EMISSION-TOMOGRAPHY, normal aging, statistical parametric mapping, anatomical standardisation, Tc-99m-ECD

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MLA
Van Laere, Koenraad, Jan Versijpt, Kurt Audenaert, et al. “99mTc-ECD Brain Perfusion SPET: Variability, Asymmetry and Effects of Age and Gender in Healthy Adults.” EUROPEAN JOURNAL OF NUCLEAR MEDICINE 28.7 (2001): 873–887. Print.
APA
Van Laere, Koenraad, Versijpt, J., Audenaert, K., Koole, M., Goethals, I., Achten, E., & Dierckx, R. (2001). 99mTc-ECD brain perfusion SPET: variability, asymmetry and effects of age and gender in healthy adults. EUROPEAN JOURNAL OF NUCLEAR MEDICINE, 28(7), 873–887.
Chicago author-date
Van Laere, Koenraad, Jan Versijpt, Kurt Audenaert, Michel Koole, Ingeborg Goethals, Eric Achten, and Rudi Dierckx. 2001. “99mTc-ECD Brain Perfusion SPET: Variability, Asymmetry and Effects of Age and Gender in Healthy Adults.” European Journal of Nuclear Medicine 28 (7): 873–887.
Chicago author-date (all authors)
Van Laere, Koenraad, Jan Versijpt, Kurt Audenaert, Michel Koole, Ingeborg Goethals, Eric Achten, and Rudi Dierckx. 2001. “99mTc-ECD Brain Perfusion SPET: Variability, Asymmetry and Effects of Age and Gender in Healthy Adults.” European Journal of Nuclear Medicine 28 (7): 873–887.
Vancouver
1.
Van Laere K, Versijpt J, Audenaert K, Koole M, Goethals I, Achten E, et al. 99mTc-ECD brain perfusion SPET: variability, asymmetry and effects of age and gender in healthy adults. EUROPEAN JOURNAL OF NUCLEAR MEDICINE. 2001;28(7):873–87.
IEEE
[1]
K. Van Laere et al., “99mTc-ECD brain perfusion SPET: variability, asymmetry and effects of age and gender in healthy adults,” EUROPEAN JOURNAL OF NUCLEAR MEDICINE, vol. 28, no. 7, pp. 873–887, 2001.
@article{142692,
  abstract     = {Reliable and high-resolution reference data for regional cerebral blood flow measured with single-photon emission tomography (SPET) are necessary for optimal clinical and research use. Therefore, a large dataset of normal technetium-99m labelled ethylene cysteine dimer (ECD) perfusion SPET in carefully screened healthy volunteers with an age range spanning six decades was created, with correction for non-uniform attenuation and scatter and based on an anatomically standardised analysis. Eighty-nine healthy volunteers, stratified for gender (46 females, 43 males; age 20-81 years), were included. Twelve volunteers underwent repeated Tc-99m-ECD SPET after 2.5 +/-2.3 weeks. An automated whole-brain volume of interest analysis with MANOVA as well as voxelwise analysis using SPM99 was conducted. Average intersubject variability was 4.8% while intrasubject reproducibility was 3.0%. An age-related decline in tracer uptake was found in the anterior cingulate gyrus, bilateral basal ganglia, left prefrontal, left lateral frontal and left superior temporal and insular cortex (all P=0.001-0.02). There was an overall increase in right/left asymmetry with age, which was most pronounced in the frontal and temporal neocortex. The most significant correlations between AI and age decade were found in the prefrontal (R=0.35, P=0.001) and superior temporal neocortex (R=0.43, P <0.001). Women had significantly higher uptake in the right parietal cortex (P <0.001), while men showed higher uptake in the cerebellum and the left anterior temporal and orbitofrontal cortex (all P <0.01). This normative dataset allows age- and gender-specific patient and group assessment of Tc-99m-ECD per fusion SPET under a wide variety of clinical circumstances in relation to normal variations and highlights the importance of both age- and gender-specific normal datasets for optimal analysis sensitivity.},
  author       = {Van Laere, Koenraad and Versijpt, Jan and Audenaert, Kurt and Koole, Michel and Goethals, Ingeborg and Achten, Eric and Dierckx, Rudi},
  issn         = {0340-6997},
  journal      = {EUROPEAN JOURNAL OF NUCLEAR MEDICINE},
  keywords     = {TECHNETIUM-99M-HMPAO,cerebral blood flow,DEMENTIA,FDG-PET,RESTING STATE,NORMAL PATTERNS,SEX-DIFFERENCES,ALZHEIMERS-DISEASE,HEXAMETHYLPROPYLENE AMINE OXIME,CEREBRAL BLOOD-FLOW,POSITRON-EMISSION-TOMOGRAPHY,normal aging,statistical parametric mapping,anatomical standardisation,Tc-99m-ECD},
  language     = {eng},
  number       = {7},
  pages        = {873--887},
  title        = {99mTc-ECD brain perfusion SPET: variability, asymmetry and effects of age and gender in healthy adults},
  url          = {http://dx.doi.org/10.1007/s002590100549},
  volume       = {28},
  year         = {2001},
}

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