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Relation entre l'uricémie et la mortalité totale, cardio-vasculaire et coronarienne dans un échantillon non-sélectionné de la population belge

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Organization
Abstract
Background: Despite more than 40 years of research on the prognostic value of hyperuricemia in relation to all-causes cardiovascular and coronary mortality, no clear consensus appears in the medical literature. Moreover, the observed relationship between hyperuricemia and the incidence of coronary heart disease mortality is related to gender. However, prospective studies including both genders are rare. Methods: A prospective study was conducted in a random sample of 5225 males and 4476 females from the Belgian population aged 25 to 74 years at the initial survey and followed for 10 years for all-causes and specific mortality. Results: The number of observed total, cardiovascular, and coronary heart disease deaths were 648 and 239, 150 and 225, and 96 and 51 in males and females respectively. At multivariate analysis, uricemia was significantly correlated with all-causes mortality in males whereas a tendency was observed in females. The same diverging association was observed for cardiovascular mortality. However, for coronary heart disease mortality, there was a very significant correlation only in females. Conclusions: Our findings confirm the observed gender-related differences in the relation of hyperuricemia with all-causes and coronary heart disease mortality. We propose possible pathogenic mechanisms concerning the relationship with coronary heart disease mortality observed only in females.
Keywords
RISK FACTOR, HONOLULU HEART PROGRAM, DISEASE RISK, FOLLOW-UP, ACID, HYPERTENSION, ASSOCIATION, COHORT, MEN, HYPERURICEMIA, uricemia, risk factor, total mortality, cardiovascular mortality, coronary mortality, prospective study

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Chicago
Eboule, ACA, P de Smet, M Dramaix, Gui De Backer, and M Kornitzer. 2001. “Relation Entre L’uricémie Et La Mortalité Totale, Cardio-vasculaire Et Coronarienne Dans Un Échantillon Non-sélectionné De La Population Belge.” REVUE D’EPIDEMIOLOGIE ET DE SANTE PUBLIQUE 49 (6): 531–539.
APA
Eboule, A., de Smet, P., Dramaix, M., De Backer, G., & Kornitzer, M. (2001). Relation entre l’uricémie et la mortalité totale, cardio-vasculaire et coronarienne dans un échantillon non-sélectionné de la population belge. REVUE D’EPIDEMIOLOGIE ET DE SANTE PUBLIQUE, 49(6), 531–539.
Vancouver
1.
Eboule A, de Smet P, Dramaix M, De Backer G, Kornitzer M. Relation entre l’uricémie et la mortalité totale, cardio-vasculaire et coronarienne dans un échantillon non-sélectionné de la population belge. REVUE D’EPIDEMIOLOGIE ET DE SANTE PUBLIQUE. 2001;49(6):531–9.
MLA
Eboule, ACA, P de Smet, M Dramaix, et al. “Relation Entre L’uricémie Et La Mortalité Totale, Cardio-vasculaire Et Coronarienne Dans Un Échantillon Non-sélectionné De La Population Belge.” REVUE D’EPIDEMIOLOGIE ET DE SANTE PUBLIQUE 49.6 (2001): 531–539. Print.
@article{142156,
  abstract     = {Background: Despite more than 40 years of research on the prognostic value of hyperuricemia in relation to all-causes cardiovascular and coronary mortality, no clear consensus appears in the medical literature. Moreover, the observed relationship between hyperuricemia and the incidence of coronary heart disease mortality is related to gender. However, prospective studies including both genders are rare. Methods: A prospective study was conducted in a random sample of 5225 males and 4476 females from the Belgian population aged 25 to 74 years at the initial survey and followed for 10 years for all-causes and specific mortality. 
Results: The number of observed total, cardiovascular, and coronary heart disease deaths were 648 and 239, 150 and 225, and 96 and 51 in males and females respectively. At multivariate analysis, uricemia was significantly correlated with all-causes mortality in males whereas a tendency was observed in females. The same diverging association was observed for cardiovascular mortality. However, for coronary heart disease mortality, there was a very significant correlation only in females. 
Conclusions: Our findings confirm the observed gender-related differences in the relation of hyperuricemia with all-causes and coronary heart disease mortality. We propose possible pathogenic mechanisms concerning the relationship with coronary heart disease mortality observed only in females.},
  author       = {Eboule, ACA and de Smet, P and Dramaix, M and De Backer, Gui and Kornitzer, M},
  issn         = {0398-7620},
  journal      = {REVUE D'EPIDEMIOLOGIE ET DE SANTE PUBLIQUE},
  keyword      = {RISK FACTOR,HONOLULU HEART PROGRAM,DISEASE RISK,FOLLOW-UP,ACID,HYPERTENSION,ASSOCIATION,COHORT,MEN,HYPERURICEMIA,uricemia,risk factor,total mortality,cardiovascular mortality,coronary mortality,prospective study},
  language     = {fre},
  number       = {6},
  pages        = {531--539},
  title        = {Relation entre l'uric{\'e}mie et la mortalit{\'e} totale, cardio-vasculaire et coronarienne dans un {\'e}chantillon non-s{\'e}lectionn{\'e} de la population belge},
  volume       = {49},
  year         = {2001},
}

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